FTIR imaging of structural changes in visceral and subcutaneous adiposity and brown to white adipocyte transdifferentiation

The Analyst ◽  
2015 ◽  
Vol 140 (7) ◽  
pp. 2205-2214 ◽  
Author(s):  
Fatma Kucuk Baloglu ◽  
Sebnem Garip ◽  
Sebastian Heise ◽  
Gudrun Brockmann ◽  
Feride Severcan
Keyword(s):  
Structural Changes ◽  
Obese Mice ◽  
Adipose Tissues ◽  
Ftir Imaging ◽  
White Adipocyte ◽  
Molecular Alterations ◽  
Ftir Microspectroscopy ◽  
Immunohistological Staining ◽  
Subcutaneous Adiposity ◽  
Subcutaneous Adipose

FTIR microspectroscopy coupled with UCP1 immunohistological staining enables the detection of obesity-related molecular alterations and transdifferentiations in visceral and subcutaneous adipose tissues in spontaneously obese mice lines.

scholarly journals Enhancement of the Antiobesity and Antioxidant Effect of Purple Sweet Potato Extracts and Enhancement of the Effects by Fermentation

Antioxidants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 888
Author(s):  
Seul Gi Lee ◽  
Jongbeom Chae ◽  
Dong Se Kim ◽  
Jung-Bok Lee ◽  
Gi-Seok Kwon ◽  
...  
Keyword(s):  
Sweet Potato ◽  
Ipomoea Batatas ◽  
Radical Scavenging ◽  
The Body ◽  
Brown Adipocyte ◽  
Obese Mice ◽  
Adipose Tissues ◽  
White Adipocytes ◽  
Beige Adipocytes ◽  
Purple Sweet Potato

The browning of white adipocytes, which transforms energy-storing white adipocytes to heat-producing beige adipocytes, is considered a strategy against metabolic diseases. Several dietary compounds, such as anthocyanins, flavonoids, and phenolic acids, induce a brown adipocyte-like phenotype in white adipocytes. In this study, we demonstrated that purple sweet potato (Ipomoea batatas) extract (PSP) exhibited potent radical scavenging activity. In addition, PSP was found to contain large amounts of phenolic, flavonoid, and anthocyanin compounds; the amount of these compounds was affected by fermentation. Functionally, PSP-induced adipose browning in high-fat-diet (HFD)-induced obese mice. The administration of PSP significantly suppressed the body weight gain and abnormal expansion of white adipose tissues in the obese mice. The expression of adipose browning-related genes was higher in the inguinal white adipose tissues from the PSP-treated mice than those in the HFD-fed mice. Moreover, PSP-treated 3T3-L1 adipocytes formed multilocular lipid droplets, similar to those formed in the 3T3-L1 adipocytes treated with a browning induction cocktail. The PSP-treated cells had an increased expression level of mitochondria and lipolysis-related genes. The browning effects of PSP were enhanced by fermentation with Lactobacillus. This study, to our knowledge, is the first to identify a new mechanism to increase the antiobesity effects of PSP by inducing adipocyte browning of adipocytes.

scholarly journals Characterisation of intramuscular, intermuscular and subcutaneous adipose tissues in yearling bulls of different genetic groups

Meat Science ◽  
2007 ◽  
Vol 76 (4) ◽  
pp. 682-691 ◽  
Author(s):  
N. Aldai ◽  
A.I. Nájera ◽  
M.E.R. Dugan ◽  
R. Celaya ◽  
K. Osoro
Keyword(s):  
Adipose Tissues ◽  
Genetic Groups ◽  
Subcutaneous Adipose

scholarly journals Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults

Aging Cell ◽  
2018 ◽  
Vol 17 (2) ◽  
pp. e12723 ◽  
Author(s):  
Ameya S Kulkarni ◽  
Erika F Brutsaert ◽  
Valentin Anghel ◽  
Kehao Zhang ◽  
Noah Bloomgarden ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Adipose Tissues ◽  
Subcutaneous Adipose

scholarly journals Different Secretory Activity of Articular and Subcutaneous Adipose Tissues from Rheumatoid Arthritis and Osteoarthritis Patients

Inflammation ◽  
2018 ◽  
Vol 42 (1) ◽  
pp. 375-386 ◽  
Author(s):  
Magdalena Plebańczyk ◽  
Anna Radzikowska ◽  
Tomasz Burakowski ◽  
Iwona Janicka ◽  
Urszula Musiałowicz ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Secretory Activity ◽  
Adipose Tissues ◽  
Subcutaneous Adipose

scholarly journals Comparison of Metabolic Network between Muscle and Intramuscular Adipose Tissues in Hanwoo Beef Cattle Using a Systems Biology Approach

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Hyun-Jeong Lee ◽  
Hye-Sun Park ◽  
Woonsu Kim ◽  
Duhak Yoon ◽  
Seongwon Seo
Keyword(s):  
Systems Biology ◽  
Beef Cattle ◽  
Metabolic Regulation ◽  
Bos Taurus ◽  
Adipose Tissues ◽  
Chemokine Signaling ◽  
Gene Network Analysis ◽  
Chemokine Signaling Pathway ◽  
Subcutaneous Adipose

The interrelationship between muscle and adipose tissues plays a major role in determining the quality of carcass traits. The objective of this study was to compare metabolic differences between muscle and intramuscular adipose (IMA) tissues in thelongissimus dorsi(LD) of Hanwoo (Bos taurus coreanae) using the RNA-seq technology and a systems biology approach. The LD sections between the 6th and 7th ribs were removed from nine (each of three cows, steers, and bulls) Hanwoo beef cattle (carcass weight of430.2±40.66 kg) immediately after slaughter. The total mRNA from muscle, IMA, and subcutaneous adipose and omental adipose tissues were isolated and sequenced. The reads that passed quality control were mapped onto the bovine reference genome (build bosTau6), and differentially expressed genes across tissues were identified. The KEGG pathway enrichment tests revealed the opposite direction of metabolic regulation between muscle and IMA. Metabolic gene network analysis clearly indicated that oxidative metabolism was upregulated in muscle and downregulated in IMA. Interestingly, pathways for regulating cell adhesion, structure, and integrity and chemokine signaling pathway were upregulated in IMA and downregulated in muscle. It is thus inferred that IMA may play an important role in the regulation of development and structure of the LD tissues and muscle/adipose communication.

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