scholarly journals Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults

Aging Cell ◽  
2018 ◽  
Vol 17 (2) ◽  
pp. e12723 ◽  
Author(s):  
Ameya S Kulkarni ◽  
Erika F Brutsaert ◽  
Valentin Anghel ◽  
Kehao Zhang ◽  
Noah Bloomgarden ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Adipose Tissues ◽  
Subcutaneous Adipose

scholarly journals Long-term stability of RNA in post-mortem bovine skeletal muscle, liver and subcutaneous adipose tissues

2007 ◽  
Vol 8 (1) ◽  
pp. 108 ◽  
Author(s):  
Bojlul Bahar ◽  
Frank J Monahan ◽  
Aidan P Moloney ◽  
Olaf Schmidt ◽  
David E MacHugh ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Post Mortem ◽  
Adipose Tissues ◽  
Term Stability ◽  
Long Term Stability ◽  
Bovine Skeletal Muscle ◽  
Subcutaneous Adipose

scholarly journals Characterisation of intramuscular, intermuscular and subcutaneous adipose tissues in yearling bulls of different genetic groups

Meat Science ◽  
2007 ◽  
Vol 76 (4) ◽  
pp. 682-691 ◽  
Author(s):  
N. Aldai ◽  
A.I. Nájera ◽  
M.E.R. Dugan ◽  
R. Celaya ◽  
K. Osoro
Keyword(s):  
Adipose Tissues ◽  
Genetic Groups ◽  
Subcutaneous Adipose

Body Fat Percentage Is Associated With Skeletal Muscle TLR4 And Tace Expression In Older Adults

2015 ◽  
Vol 47 ◽  
pp. 412
Author(s):  
Ian D. Connors ◽  
Rachael E. Mott ◽  
Rudra H. Trivedi ◽  
Allison M. Morrison ◽  
Alexandra M. Bishop ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Body Fat ◽  
Body Fat Percentage ◽  
Fat Percentage

METABOLISM IN ADIPOSE TISSUE AND MUSCLE OF THE YOUNG PIG

1990 ◽  
Vol 70 (1) ◽  
pp. 199-206 ◽  
Author(s):  
O. ADEOLA ◽  
B. W. McBRIDE ◽  
R. O. BALL ◽  
L. G. YOUNG
Keyword(s):  
Skeletal Muscle ◽  
Protein Synthesis ◽  
Adipose Tissue ◽  
Key Words ◽  
Adenosine Deaminase ◽  
Subcutaneous Adipose Tissue ◽  
Muscle Metabolism ◽  
Acetate Incorporation ◽  
Glycerol Release ◽  
Subcutaneous Adipose

Subcutaneous adipose tissue and intercostal and sartorius muscles from five barrows and five gilts at 20 kg liveweight were used to study lipogenesis, lipolysis, Na+, K+-ATPase-dependent respiration and protein synthesis. Lipogenesis rate measured by 14C-acetate incorporation into lipid was similar between barrows and gilts; and 100 μg insulin per mL enhanced (P < 0.1) subcutaneous adipose tissue lipogenesis by 74%. Lipolysis rate quantitated by glycerol release was similar between barrows and gilts (3546 and 4160 nmol g−1 2 h−1). Adenosine deaminase and norepinephrine together enhanced adipose tissue lipolytic response by 102%. Fractional and absolute rates of protein synthesis were similar between barrows and gilts (3.24 and 3.69% d−1; 6.01 and 6.06 mg g−1 d−1); and between intercostal and sartorius muscles. Barrows had lower Na+, K+-ATPase-dependent respiration than gilts and the maintenance of Na+ and K+ transmembrane ionic gradient in the muscle preparations accounted for 23–26% of total respiration. Key words: Pigs, adipose tissue, skeletal muscle, metabolism

scholarly journals Resistance Training Enhances Skeletal Muscle Innervation Without Modifying the Number of Satellite Cells or their Myofiber Association in Obese Older Adults

2015 ◽  
Vol 71 (10) ◽  
pp. 1273-1280 ◽  
Author(s):  
María Laura Messi ◽  
Tao Li ◽  
Zhong-Min Wang ◽  
Anthony P. Marsh ◽  
Barbara Nicklas ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Resistance Training ◽  
Satellite Cells ◽  
Muscle Innervation

Leucine augments specific skeletal muscle mitochondrial respiratory pathways during recovery following 7 days of physical inactivity in older adults

2021 ◽  
Author(s):  
Emily J. Arentson-Lantz ◽  
Jasmine Mikovic ◽  
Nisha Bhattarai ◽  
Christopher S. Fry ◽  
Séverine Lamon ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Body Weight ◽  
Insulin Sensitivity ◽  
Bed Rest ◽  
Metabolic Clearance ◽  
Leucine Supplementation ◽  
Respiratory Capacity ◽  
Antioxidant Defense Systems ◽  
Mitochondrial Respiratory

Leucine supplementation attenuates the loss of skeletal muscle mass and function in older adults during bed rest. We sought to determine if leucine could also preserve and/or restore mitochondrial function and muscle oxidative capacity during periods of disuse and rehabilitation. Healthy older adults (69.1 ± 1.1 years) consumed a structured diet with supplemental leucine (LEU: 0.06 g/ kg body weight/ meal; n=8) or alanine (CON: 0.06 g/ kg body weight/meal; n=8) during 7 days of bed rest and 5 days of inpatient rehabilitation. A 75 g oral glucose tolerance test was performed at baseline (PreBR), after bed rest (PostBR) and rehabilitation (PostRehab) and used to calculate an indicator of insulin sensitivity, metabolic clearance rate. (MCR). Tissue samples from the m. vastus lateralis were collected PreBR, PostBR, and PostRehab to assess mitochondrial respiratory capacity and protein markers of the oxidative phosphorylation and a marker of the antioxidant defense systems. During bed rest, leucine tended to preserve insulin sensitivity (Change in MCR, CON vs. LEU: -3.5 ± 0.82 vs LEU: -0.98 ± 0.88, p=0.054), but had no effect on mitochondrial respiratory capacity (Change in State 3+succinate CON vs. LEU -8.7 ± 6.1 vs. 7.3 ± 4.1 pmol O2/sec/mg tissue, p=0.10) Following rehabilitation, leucine increased ATP-linked respiration (CON vs. LEU: -8.9 ± 6.2 vs. 15.5± 4.4 pmol O2/sec/mg tissue, p=0.0042). While the expression of mitochondrial respiratory and antioxidant proteins was not impacted, leucine supplementation preserved specific pathways of mitochondrial respiration, insulin sensitivity and a marker of oxidative stress during bed rest and rehabilitation.

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