Coumarin-containing photo-responsive nanocomposites for NIR light-triggered controlled drug release via a two-photon process

2013 ◽  
Vol 1 (43) ◽  
pp. 5942 ◽  
Author(s):  
Weidong Ji ◽  
Najun Li ◽  
Dongyun Chen ◽  
Xiuxiu Qi ◽  
Wenwei Sha ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Two Photon ◽  
Nir Light ◽  
Photon Process

scholarly journals NIR-Responsive Lysosomotropic Phototrigger: ʽAIE + ESIPTʼ Active Naphthalene Based Single Component Photoresponsive Nanocarrier with Two-Photon Uncaging and Real-Time Monitoring Ability

2021 ◽  
Author(s):  
Biswajit Roy ◽  
Rakesh Mengji ◽  
Samrat Roy ◽  
Bipul Pal ◽  
Avijit Jana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Real Time ◽  
Near Infrared ◽  
Single Component ◽  
Photon Absorption ◽  
Real Time Monitoring ◽  
Two Photon ◽  
Nir Light

In recent times, organelle-targeted drug delivery systems gained tremendous attention due to the site specific delivery of active drug molecules resulting in enhanced bioefficacy. In this context, the phototriggered drug delivery system (DDS) for releasing an active molecule is superior as it provides spatial and temporal control over the release. So far, near infrared (NIR) light responsive organelle targeted DDS has not yet been developed. Hence, we introduced a two-photon NIR-light responsive lysosome targeted ʽAIE + ESIPTʼ active single component DDS based on naphthalene chromophore. The Two-photon absorption cross-section of our DDS is 142 GM at 850 nm. The DDS was converted into pure organic nanoparticles for biological applications. Our nano-DDS is capable of selective targeting, AIE-luminogenic imaging, and drug release within the lysosome. In vitro studies using cancerous cell lines showed that our single component photoresponsive nanocarrier exhibited enhanced cytotoxicity and real-time monitoring ability of the drug release.

Near-infrared light-triggered drug release from UV-responsive diblock copolymer-coated upconversion nanoparticles with high monodispersity

2018 ◽  
Vol 6 (21) ◽  
pp. 3531-3540 ◽  
Author(s):  
Jun Xiang ◽  
Xia Tong ◽  
Feng Shi ◽  
Qiang Yan ◽  
Bing Yu ◽  
...  
Keyword(s):  
Drug Release ◽  
Diblock Copolymer ◽  
Near Infrared ◽  
Controlled Drug Release ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Near Infrared Light ◽  
Nir Light ◽  
Triggered Drug Release

The preparation of a new near-infrared (NIR) light-responsive nanocarrier for controlled drug release is demonstrated.

Electrospun Upconverting Nanofibrous Hybrids with Smart NIR-Light-Controlled Drug Release for Wound Dressing

2020 ◽  
Vol 3 (10) ◽  
pp. 7219-7227
Author(s):  
Ho Ying Huang ◽  
Artiom Skripka ◽  
Liana Zaroubi ◽  
Brandon L. Findlay ◽  
Fiorenzo Vetrone ◽  
...  
Keyword(s):  
Drug Release ◽  
Wound Dressing ◽  
Controlled Drug Release ◽  
Nir Light

Anticancer Drug Release from a Mesoporous Silica Based Nanophotocage Regulated by Either a One- or Two-Photon Process

2010 ◽  
Vol 132 (31) ◽  
pp. 10645-10647 ◽  
Author(s):  
Qiuning Lin ◽  
Qi Huang ◽  
Chunyan Li ◽  
Chunyan Bao ◽  
Zhenzhen Liu ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Anticancer Drug ◽  
Two Photon ◽  
Photon Process

scholarly journals Fabrication of Upconverting Hybrid Nanoparticles for Near-Infrared Light Triggered Drug Release

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Ranran Zhang ◽  
Risheng Yao ◽  
Binbin Ding ◽  
Yuxin Shen ◽  
Shengwen Shui ◽  
...  
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Uv Light ◽  
Nile Red ◽  
Controlled Drug Release ◽  
Hybrid Nanoparticles ◽  
Infrared Light ◽  
Nir Light ◽  
Triggered Drug Release ◽  
Model Drug

Low tissue penetration and harmful effects of (ultraviolet) UV or visible light on normal tissue limit exploiting nanocarriers for the application of light-controlled drug release. Two strategies may solve the problem: one is to improve the sensitivity of the nanocarriers to light to decrease the radiation time; the other one is using more friendly light as the trigger. In this work, we fabricated a core-shell hybrid nanoparticle with an upconverting nanoparticle (UCNP) as the core and thermo- and light-responsive block copolymers as the shell to combine the two strategies together. The results indicated that the sensitivity of the block copolymer to light could be enhanced by decreasing the photolabile moieties in the polymer, and the UCNP could transfer near-infrared (NIR) light, which is more friendly to tissue and cell, to UV light to trigger the phase conversion of the block polymersin situ. Using Nile Red (NR) as the model drug, the hybrid nanoparticles were further proved to be able to act as carriers with the character of NIR triggered drug release.

Novel phthalocyanine-based micelles/PNIPAM composite hydrogels: spatially/temporally controlled drug release triggered by NIR laser irradiation

2020 ◽  
Vol 44 (21) ◽  
pp. 8705-8709
Author(s):  
Lu Li ◽  
Wancheng Zhao ◽  
Zheng Qu ◽  
Lei Shi ◽  
Shengnan Tan ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Laser Irradiation ◽  
Anticancer Drugs ◽  
Near Infrared ◽  
Biomedical Application ◽  
Controlled Drug Release ◽  
Nir Light ◽  
Responsive Hydrogels ◽  
Nir Laser

Near-infrared (NIR) light-responsive hydrogels hold significant potential for biomedical application, especially in the remote-controlled release of anticancer drugs.

ortho-Nitrobenzyl alcohol based two-photon excitation controlled drug release system

RSC Advances ◽  
2012 ◽  
Vol 2 (1) ◽  
pp. 156-160 ◽  
Author(s):  
Xing Wang ◽  
Stefan Werner ◽  
Thomas Weiß ◽  
Klaus Liefeith ◽  
Christian Hoffmann
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Release System ◽  
Two Photon ◽  
Photon Excitation ◽  
Nitrobenzyl Alcohol ◽  
Drug Release System ◽  
Two Photon Excitation

A thermosensitive nanoplatform for photoacoustic imaging and NIR light triggered chemo-photothermal therapy

2020 ◽  
Vol 8 (15) ◽  
pp. 4299-4307
Author(s):  
Zikang Chen ◽  
Yinuo Tu ◽  
Di Zhang ◽  
Chuang Liu ◽  
Yuping Zhou ◽  
...  
Keyword(s):  
Drug Release ◽  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Controlled Drug Release ◽  
Nir Light

A thermosensitive nanoplatform CDTSL achieves NIR light controlled drug release and can be applied for photoacoustic imaging and chemo-photothermal therapy.

A NIR-triggered gatekeeper of supramolecular conjugated unimicelles with two-photon absorption for controlled drug release

2019 ◽  
Vol 55 (47) ◽  
pp. 6735-6738 ◽  
Author(s):  
Yu Huang ◽  
Lingyue Shen ◽  
Dongbo Guo ◽  
Wumaier Yasen ◽  
Yan Wu ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Drug Release ◽  
Fluorescence Resonance Energy Transfer ◽  
Near Infrared ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Controlled Drug Release ◽  
Photon Absorption ◽  
Two Photon Absorption ◽  
Two Photon

Near-infrared-sensitive supramolecular hyperbranched conjugated unimicelles were constructed for controlled drug release via two-photon excited fluorescence resonance energy transfer.

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