Near-infrared light-triggered drug release from UV-responsive diblock copolymer-coated upconversion nanoparticles with high monodispersity

2018 ◽  
Vol 6 (21) ◽  
pp. 3531-3540 ◽  
Author(s):  
Jun Xiang ◽  
Xia Tong ◽  
Feng Shi ◽  
Qiang Yan ◽  
Bing Yu ◽  
...  
Keyword(s):  
Drug Release ◽  
Diblock Copolymer ◽  
Near Infrared ◽  
Controlled Drug Release ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Near Infrared Light ◽  
Nir Light ◽  
Triggered Drug Release

The preparation of a new near-infrared (NIR) light-responsive nanocarrier for controlled drug release is demonstrated.

scholarly journals Fabrication of Upconverting Hybrid Nanoparticles for Near-Infrared Light Triggered Drug Release

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Ranran Zhang ◽  
Risheng Yao ◽  
Binbin Ding ◽  
Yuxin Shen ◽  
Shengwen Shui ◽  
...  
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Uv Light ◽  
Nile Red ◽  
Controlled Drug Release ◽  
Hybrid Nanoparticles ◽  
Infrared Light ◽  
Nir Light ◽  
Triggered Drug Release ◽  
Model Drug

Low tissue penetration and harmful effects of (ultraviolet) UV or visible light on normal tissue limit exploiting nanocarriers for the application of light-controlled drug release. Two strategies may solve the problem: one is to improve the sensitivity of the nanocarriers to light to decrease the radiation time; the other one is using more friendly light as the trigger. In this work, we fabricated a core-shell hybrid nanoparticle with an upconverting nanoparticle (UCNP) as the core and thermo- and light-responsive block copolymers as the shell to combine the two strategies together. The results indicated that the sensitivity of the block copolymer to light could be enhanced by decreasing the photolabile moieties in the polymer, and the UCNP could transfer near-infrared (NIR) light, which is more friendly to tissue and cell, to UV light to trigger the phase conversion of the block polymersin situ. Using Nile Red (NR) as the model drug, the hybrid nanoparticles were further proved to be able to act as carriers with the character of NIR triggered drug release.

Near-infrared light-controlled drug release and cancer therapy with polymer-caged upconversion nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (7) ◽  
pp. 5269-5276 ◽  
Author(s):  
Qingjian Xing ◽  
Najun Li ◽  
Yang Jiao ◽  
Dongyun Chen ◽  
Jiaying Xu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Self Assembly ◽  
Near Infrared ◽  
Controlled Drug Release ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Assembly Process ◽  
The Core ◽  
Triggered Drug Release

The core–shell nanocarrier, based on spiropyran-containing copolymer coated upconversion nanocomposites, was successfully prepared via a facile self-assembly process for NIR-triggered drug release and cancer therapy.

Near-infrared light-triggered drug release nanogels for combined photothermal-chemotherapy of cancer

2015 ◽  
Vol 3 (7) ◽  
pp. 1147-1156 ◽  
Author(s):  
Minghui Zan ◽  
Junjie Li ◽  
Mingming Huang ◽  
Shanqing Lin ◽  
Dan Luo ◽  
...  
Keyword(s):  
Drug Release ◽  
Indocyanine Green ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Nir Light ◽  
Triggered Drug Release

Near-infrared (NIR) light-triggered drug release polymeric nanogels were fabricated based on host–guest interaction and were explored to encapsulate indocyanine green (ICG) and doxorubicin (DOX) for combined photothermal-chemotherapy of cancer.

scholarly journals Design of hybrid nanovehicles for remotely triggered drug release: an overview

2015 ◽  
Vol 3 (30) ◽  
pp. 6117-6147 ◽  
Author(s):  
Ji Liu ◽  
Christophe Detrembleur ◽  
Stéphane Mornet ◽  
Christine Jérôme ◽  
Etienne Duguet
Keyword(s):  
Drug Release ◽  
Magnetic Fields ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Release Mechanisms ◽  
Triggered Drug Release ◽  
Alternating Magnetic Fields

This review addresses the advantages of remote triggers, e.g. ultrasounds, near infrared light and alternating magnetic fields, the fabrication of the hybrid nanovehicles, the release mechanisms and the next challenges.

scholarly journals Near infrared light-driven water oxidation in a molecule-based artificial photosynthetic device using an upconversion nano-photosensitizer

2015 ◽  
Vol 51 (65) ◽  
pp. 13008-13011 ◽  
Author(s):  
Xiaomin Liu ◽  
Hung-Cheng Chen ◽  
Xianggui Kong ◽  
Youlin Zhang ◽  
Langping Tu ◽  
...  
Keyword(s):  
Water Oxidation ◽  
Near Infrared ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Near Infrared Light ◽  
Photosynthetic System ◽  
Nir Light ◽  
Artificial Photosynthetic ◽  
Novel Concept

A NIR light driven nano-photosensitizer is reported as a novel concept in an artificial photosynthetic system that integrates upconversion nanoparticles with Pt(ii)-porphyrin.

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