scholarly journals Synthesis of thiolated and acrylated nanoparticles using thiol-ene click chemistry: towards novel mucoadhesive materials for drug delivery

RSC Advances ◽  
2013 ◽  
Vol 3 (30) ◽  
pp. 12275 ◽  
Author(s):  
Anna Štorha ◽  
Ellina A. Mun ◽  
Vitaliy V. Khutoryanskiy
Keyword(s):  
Drug Delivery ◽  
Click Chemistry

pH-Triggered release of gemcitabine from polymer coated nanodiamonds fabricated by RAFT polymerization and copper free click chemistry

2016 ◽  
Vol 7 (40) ◽  
pp. 6220-6230 ◽  
Author(s):  
Haiwang Lai ◽  
Mingxia Lu ◽  
Hongxu Lu ◽  
Martina H. Stenzel ◽  
Pu Xiao
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Click Chemistry ◽  
Raft Polymerization ◽  
Stimuli Responsive ◽  
Triggered Release

Prodrug (gemcitabine)-based polymer coated nanodiamonds as stimuli-responsive drug delivery platforms for the treatment of pancreatic cancer.

Rapid conjugation of nanoparticles, proteins and siRNAs to microbubbles by strain-promoted click chemistry for ultrasound imaging and drug delivery

2019 ◽  
Vol 10 (6) ◽  
pp. 705-717 ◽  
Author(s):  
Xifeng Liu ◽  
Ping Gong ◽  
Pengfei Song ◽  
Feng Xie ◽  
A. Lee Miller II ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Click Chemistry ◽  
Ultrasound Imaging ◽  
Ultrasound Microbubbles

Strain-promoted alkyne–azide cycloaddition (SPAAC) click chemistry was applied for the rapid conjugation of nanoparticles, proteins, and siRNA-micelles to ultrasound microbubbles.

scholarly journals Click and photo-release dual-functional nucleic acid nanostructures

2019 ◽  
Vol 55 (65) ◽  
pp. 9709-9712 ◽  
Author(s):  
Vibhav A. Valsangkar ◽  
Arun Richard Chandrasekaran ◽  
Lifeng Zhuo ◽  
Song Mao ◽  
Goh Woon Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Click Chemistry ◽  
Dna Nanostructures ◽  
Dual Functional

DNA nanostructures are useful in drug delivery, with cargos attached via click chemistry and released using light-based triggers.

scholarly journals Bio-orthogonal triazolinedione (TAD) crosslinked protein nanocapsules affect protein adsorption and cell interaction

2020 ◽  
Vol 11 (23) ◽  
pp. 3821-3830 ◽  
Author(s):  
Marie-Luise Frey ◽  
Johanna Simon ◽  
Maximilian Brückner ◽  
Volker Mailänder ◽  
Svenja Morsbach ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Click Chemistry ◽  
Protein Adsorption ◽  
Drug Delivery Systems ◽  
Cell Interaction ◽  
Delivery Systems ◽  
High Loading ◽  
Loading Capacity ◽  
Low Toxicity

Albumin-based protein nanocarriers obtained by TAD click chemistry have been widely exploited as drug delivery systems, since they show excellent degradability, low toxicity, but at the same time provide high loading capacity and relevant uptake into cells.

Studies and synthetic methodology of Nampt inhibition

2018 ◽  
Author(s):  
◽  
Ellen Moore
Keyword(s):  
Drug Delivery ◽  
Click Chemistry ◽  
Cancer Cells ◽  
Delivery Vehicle ◽  
University Of Missouri ◽  
Carborane Derivative ◽  
Reactive Functional Group ◽  
Nicotinamide Phosphoribosyl Transferase ◽  
The University ◽  
First Time

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The purpose of this research is to study and synthesize an array of a highly potent pharmaceuticals that can selectively cause apoptosis in various cancer cells and to synthesize click chemistry components to be used in drug delivery systems. Utilizing hydrophobic properties of carboranes, an array of drug derivatives were synthesized as potential Nampt inhibitors. These drugs selectively bind to nicotinamide Phosphoribosyl transferase (Nampt), preventing cancer cells from replenishing nicotinamide adenine dinucleotide (NAD) through the salvage pathway which leads to apoptosis. The association constants of unsubstituted o-, m-, and p-carborane, adamantane, and their derivatives with [beta]-cyclodextrin ([beta]-CD) are reported for the first time using displacement binding in an aqueous solution. Although hydrophobicity plays a major role in the association with [beta]-CD, unsubstituted o-carborane which is the least hydrophobic carborane derivative, exhibits the highest Ka' of 2690 M[subscript -1]. The Ka' values for the m-, and p-carborane isomers decrease with decreasing dipole moment (1830 M-1 and 1560 M[subscript -1] respectively). Adamantane exhibits a Ka' value lower than each of the three carborane isomers at 1410 M[subscript -1]. These studies indicate that cyclodextrin inclusion complexes could be well suited as a drug delivery vehicle for our carborane containing drug derivatives. Click chemistry linkers functionalized with azide or alkyne functional groups were synthesized for use in a peptide drug conjugate. These linkers also utilized an amine reactive functional group to allow for reaction with amines found in peptides.

“Click” functionalization of dual stimuli-responsive polymer nanocapsules for drug delivery systems

2017 ◽  
Vol 8 (20) ◽  
pp. 3056-3065 ◽  
Author(s):  
Wen Jing Yang ◽  
Tingting Zhao ◽  
Peng Zhou ◽  
Simou Chen ◽  
Yu Gao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Click Chemistry ◽  
Surface Functionalization ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Responsive Polymer ◽  
Stimuli Responsive Polymer

“Clickable” and dual stimuli-responsive nanocapsules were developed for facile surface functionalizationviathiol–yne click chemistry and employed as drug nano-carriers.

scholarly journals Histamine-functionalized copolymer micelles as a drug delivery system in 2D and 3D models of breast cancer

2015 ◽  
Vol 3 (12) ◽  
pp. 2472-2486 ◽  
Author(s):  
Yuning Zhang ◽  
Pontus Lundberg ◽  
Maren Diether ◽  
Christian Porsch ◽  
Caroline Janson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Block Copolymers ◽  
Click Chemistry ◽  
Drug Delivery System ◽  
Delivery System ◽  
3D Models ◽  
Copolymer Micelles ◽  
2D And 3D

Histamine functionalized block copolymers were prepared with different ratios of histamine and octyl or benzyl groups using UV-initiated thiol-ene click chemistry.

Surface Functionalization of Porous Coordination Nanocages Via Click Chemistry and Their Application in Drug Delivery

2010 ◽  
Vol 23 (1) ◽  
pp. 90-93 ◽  
Author(s):  
Dan Zhao ◽  
Songwei Tan ◽  
Daqiang Yuan ◽  
Weigang Lu ◽  
Yohannes H. Rezenom ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Click Chemistry ◽  
Surface Functionalization
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