Sequential drug release for synergistic cancer treatment and immunity promotion

RSC Advances ◽  
2013 ◽  
Vol 3 (32) ◽  
pp. 13399 ◽  
Author(s):  
Mingsheng Chen ◽  
Xinyuan Zhu ◽  
Deyue Yan
Keyword(s):  
Drug Release ◽  
Cancer Treatment ◽  
Sequential Drug Release

scholarly journals Correction to Supramolecular Drug–Drug Complex Vesicles Enable Sequential Drug Release for Enhanced Combination Therapy

2020 ◽  
Vol 12 (39) ◽  
pp. 44382-44382
Author(s):  
Chengfei Liu ◽  
Chunpu Li ◽  
Cui Pang ◽  
Muqiong Li ◽  
Huixin Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Combination Therapy ◽  
Sequential Drug Release ◽  
Drug Complex

Multimodal Cancer Treatment: Real Time Monitoring, Optimization, and Synergistic Effects

2008 ◽  
Vol 7 (5) ◽  
pp. 409-414 ◽  
Author(s):  
Gunnar Myhr
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Adjuvant Therapy ◽  
Ionizing Radiation ◽  
Cancer Treatment ◽  
Real Time ◽  
Treatment System ◽  
Multi Drug Resistance ◽  
Real Time Monitoring ◽  
Site Specific

The primary objective of this analysis is to provide the theoretical framework for a novel multimodal cancer treatment system emphasizing the use of ultrasound as a synergistic drug release mechanism, real time monitoring by MRI of hyperthermic, pO2, and ultrasound induced released effects. The aim is to provide a cure for the 20% of cancer victims who will die of complications from local solid tumors. Adjuvant therapy usually refers to surgery preceding or following chemotherapy and/or ionizing radiation treatment to decrease the risk of recurrence, but the absolute benefit for survival obtained with adjuvant therapy compared to control is only approximately 6%. Tumor hypoxia represents a primary therapeutic concern, besides multi-drug resistance (MDR), because it can reduce the effectiveness of drugs and radiotherapy; well-oxygenated cells require one-third the dose of hypoxic cells to achieve a given level of cell killing. The era of systemic and indiscriminate chemotherapeutic drug delivery into both healthy and pathologic tissues is near an end. Targeted drug delivery using nanoparticles is emerging as the new vehicle, either as a single treatment option, as part of adjuvant procedures or as a component of a multimodal cancer treatment system. There are more than 100 nanosized liposomes or particles, and conjugated anticancer agents in various stages of preclinical and clinical development. Active targeting can be achieved by site-specific delivery or site-specific triggering. Ultrasound can be utilized as both a site triggering and synergistic mechanism in drug release. The process can be monitored using MRI by a physical process called cavitation. An analysis of low frequency ultrasound exposure in combination with liposomally encapsulated doxorubicin (Caelyx) on Balb/c nude mice inoculated with a WiDr (human colon cancer) tumor cell line provided tumor growth inhibition of 30–40%. Mild hyperthermia causes mean intratumor pO2 to increase by 25% and enhances tumor radiosensitization. Hyperthermia causes the extravasation of liposome nanoparticles in deep tumor regions. Ionizing radiation improves the distribution and uptake of drugs. Liposomally encapsulated drugs and ultrasound mediated hyperthermia have been proven to circumvent MDR effects. Hyperthermic effects and pO2 monitoring of bodily fluid have been performed by MRI. It is hypothesized that increased vascularization and subsequent increase in pO2 levels to hypoxic regions, and monitoring of drug release through cavitation, can facilitate optimized real time concomitant or sequential treatments of drug therapy, hyperthermia, ionizing radiation, etc., before or after surgery. An improved therapeutic index with the use of the outlined system seems probable.

Cancer Treatment: Medibots: Dual-Action Biogenic Microdaggers for Single-Cell Surgery and Drug Release (Adv. Mater. 5/2016)

2016 ◽  
Vol 28 (5) ◽  
pp. 785-785 ◽  
Author(s):  
Sarvesh Kumar Srivastava ◽  
Mariana Medina-Sánchez ◽  
Britta Koch ◽  
Oliver G. Schmidt
Keyword(s):  
Drug Release ◽  
Cancer Treatment ◽  
Single Cell ◽  
Dual Action ◽  
Cell Surgery

Biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment

2018 ◽  
Vol 6 (2) ◽  
pp. 324-331 ◽  
Author(s):  
Gaizhen Kuang ◽  
Zhiyun Zhang ◽  
Shi Liu ◽  
Dongfang Zhou ◽  
Xiaolan Lu ◽  
...  
Keyword(s):  
Drug Release ◽  
Cancer Treatment

We report the first attempt to apply biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment.

scholarly journals Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment

Nano Research ◽  
2019 ◽  
Vol 12 (5) ◽  
pp. 999-1008 ◽  
Author(s):  
Yongjuan Li ◽  
Jian Hu ◽  
Xun Liu ◽  
Yong Liu ◽  
Shixian Lv ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Drug Release ◽  
Cancer Treatment ◽  
On Demand ◽  
Anti Cancer

Therapeutic Nanocarriers with Hydrogen Peroxide-Triggered Drug Release for Cancer Treatment

2013 ◽  
Vol 14 (5) ◽  
pp. 1627-1636 ◽  
Author(s):  
Jinyao Liu ◽  
Yan Pang ◽  
Zhaoyang Zhu ◽  
Dali Wang ◽  
Chunting Li ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Drug Release ◽  
Cancer Treatment ◽  
Triggered Drug Release

Core–shell noble-metal@zeolitic-imidazolate-framework nanocarriers with high cancer treatment efficiency in vitro

2019 ◽  
Vol 7 (7) ◽  
pp. 1050-1055 ◽  
Author(s):  
Liangcan He ◽  
Kanglei Pang ◽  
Wenwen Liu ◽  
Yue Tian ◽  
Lin Chang ◽  
...  
Keyword(s):  
Drug Release ◽  
Cancer Treatment ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Core Shell ◽  
Treatment Efficiency ◽  
Zeolitic Imidazolate Framework ◽  
High Drug ◽  
High Drug Loading

Core–shell Au@zeolitic-imidazolate-framework nanocarriers with high drug-loading, controlled drug release properties, and high cancer treatment efficiency.

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