Convertible Organic Nanoparticles for Near-Infrared Photothermal Ablation of Cancer Cells

2010 ◽  
Vol 123 (2) ◽  
pp. 461-464 ◽  
Author(s):  
Jaemoon Yang ◽  
Jihye Choi ◽  
Doyeon Bang ◽  
Eunjung Kim ◽  
Eun-Kyung Lim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Near Infrared ◽  
Organic Nanoparticles ◽  
Photothermal Ablation

Convertible Organic Nanoparticles for Near-Infrared Photothermal Ablation of Cancer Cells

2010 ◽  
Vol 50 (2) ◽  
pp. 441-444 ◽  
Author(s):  
Jaemoon Yang ◽  
Jihye Choi ◽  
Doyeon Bang ◽  
Eunjung Kim ◽  
Eun-Kyung Lim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Near Infrared ◽  
Organic Nanoparticles ◽  
Photothermal Ablation

Organic molecules with propeller structures for efficient photoacoustic imaging and photothermal ablation of cancer cells

2017 ◽  
Vol 1 (8) ◽  
pp. 1556-1562 ◽  
Author(s):  
Xiaolei Cai ◽  
Jie Liu ◽  
Weng Heng Liew ◽  
Yukun Duan ◽  
Junlong Geng ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Small Molecule ◽  
Photothermal Therapy ◽  
Organic Molecules ◽  
Photoacoustic Imaging ◽  
Organic Nanoparticles ◽  
Photothermal Ablation ◽  
Donor Acceptor

We report organic nanoparticles for efficient photoacoustic imaging and photothermal therapy, based on the small molecule BTPETTQ which has a propeller structure and a donor–acceptor–donor configuration.

Porous Pd nanoparticles with high photothermal conversion efficiency for efficient ablation of cancer cells

Nanoscale ◽  
2014 ◽  
Vol 6 (8) ◽  
pp. 4345-4351 ◽  
Author(s):  
Jia-Wen Xiao ◽  
Shi-Xuan Fan ◽  
Feng Wang ◽  
Ling-Dong Sun ◽  
Xiao-Yu Zheng ◽  
...  
Keyword(s):  
Porous Structure ◽  
Cancer Cells ◽  
Hela Cells ◽  
Near Infrared ◽  
Pd Nanoparticles ◽  
Photothermal Effect ◽  
High Efficacy ◽  
Photothermal Ablation ◽  
Nir Absorption ◽  
Very High

Pd NPs with a porous structure exhibit enhanced near infrared (NIR) absorption and enhanced photothermal effect compared to Pd nanocubes with a similar size, and show very high efficacy in photothermal ablation of HeLa cells.

scholarly journals Gold Nanorod-Mediated Photothermal Modulation for Localized Ablation of Cancer Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Yoochan Hong ◽  
Eugene Lee ◽  
Jihye Choi ◽  
Seung Jae Oh ◽  
Seungjoo Haam ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Laser Power ◽  
Near Infrared ◽  
Gold Nanorod ◽  
Photothermal Effect ◽  
Transduction Efficiency ◽  
Dead Cell ◽  
Photothermal Ablation ◽  
Power Densities ◽  
Nir Laser

We estimated the photothermal transduction efficiency of gold nanorod (GNR) solutions for different GNR concentrations and irradiation laser power. In particular, we verified that the degree of cell death area could be modulated by GNR concentration and irradiation laser power. The efficacy of GNR-produced photothermal ablation of cancer cells was evaluated by irradiating GNRs in the presence of MDA-MB-231 breast cancer cells with a near-infrared (NIR) laser at different laser power densities and irradiation times. GNR-induced photothermal ablation was applied successfully to cancer cells at various NIR laser power densities and irradiation times and was characterized with live-dead cell staining. Through these techniques, we established the system for not only verification of induced photothermal effect using NIR laser and thermocouple, but also identification of uptake efficiency for GNRs and cell viability using dark field and fluorescence imaging, respectively.

scholarly journals Facile fabricating of rGO and Au/rGO nanocomposites using Brassica oleracea var. gongylodes biomass for non-invasive approach in cancer therapy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Fatemeh Yousefimehr ◽  
Saeed Jafarirad ◽  
Roya Salehi ◽  
Mohammad Sadegh Zakerhamidi
Keyword(s):  
Breast Cancer ◽  
Green Synthesis ◽  
Cancer Cells ◽  
Brassica Oleracea ◽  
Photothermal Therapy ◽  
Breast Cancer Cells ◽  
Near Infrared ◽  
Therapeutic Effects ◽  
Invasive Approach ◽  
Au Nps

AbstractIn this study, we report a facile green-synthesis route for the fabrication of reduced graphene oxide (rGO) using biomass of Brassica oleracea var. gongylodes (B. oleracea). In addition, we have attempted to provide a green synthesis approach to prepare Gold nanoparticles (Au NPs) on the surface of rGO by using stem extract of B. oleracea. The synthesized Au/rGO nanocomposite was evaluated using UV–visible and FTIR spectroscopy, XRD, Raman, FE-SEM, EDX, AFM and DLS techniques. The obtained results demonstrated that the synthesized Au NPs on the surface of rGO was spherical with sizes ranging about 12–18 nm. The Au/rGO NC was, also, developed as photo-synthesizer system for the photothermal therapy (PTT) of MCF7 breast cancer cells. The near-infrared (NIR) photothermal properties of Au/rGO NCs was evaluated using a continuous laser at 808 nm with power densities of 1 W.cm−2. Their photothermal efficacy on MCF7 breast cancer cells after optimizing the proper concentration of the NCs were evaluated by MTT assay, Cell cycle and DAPI staining. In addition, the potential of the synthesized Au/rGO NCs on reactive oxygen species generating and antioxidant activity were assessed by DPPH. Au/rGO NCs possess high capacity to light-to-heat conversion for absorption in range NIR light, and it is able to therapeutic effects on MCF7 cells at a low concentration. The maximum amount of cell death is 40.12% which was observed in treatment groups that received a combination of Au/rGO NCs and laser irradiation. The results demonstrate that the nanomaterials synthesized by green approach lead to efficient destruction of cancer cell and might thus serve as an excellent theranostic agent in Photothermal therapy applications.

scholarly journals Fibroblast activation protein targeted near infrared photoimmunotherapy (NIR PIT) overcomes therapeutic resistance in human esophageal cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ryoichi Katsube ◽  
Kazuhiro Noma ◽  
Toshiaki Ohara ◽  
Noriyuki Nishiwaki ◽  
Teruki Kobayashi ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Near Infrared ◽  
Fibroblast Activation Protein ◽  
Therapeutic Resistance ◽  
Fibroblast Activation ◽  
Human Esophageal Cancer

AbstractCancer-associated fibroblasts (CAFs) have an important role in the tumor microenvironment. CAFs have the multifunctionality which strongly support cancer progression and the acquisition of therapeutic resistance by cancer cells. Near-infrared photoimmunotherapy (NIR-PIT) is a novel cancer treatment that uses a highly selective monoclonal antibody (mAb)-photosensitizer conjugate. We developed fibroblast activation protein (FAP)-targeted NIR-PIT, in which IR700 was conjugated to a FAP-specific antibody to target CAFs (CAFs-targeted NIR-PIT: CAFs-PIT). Thus, we hypothesized that the control of CAFs could overcome the resistance to conventional chemotherapy in esophageal cancer (EC). In this study, we evaluated whether EC cell acquisition of stronger malignant characteristics and refractoriness to chemoradiotherapy are mediated by CAFs. Next, we assessed whether the resistance could be rescued by eliminating CAF stimulation by CAFs-PIT in vitro and in vivo. Cancer cells acquired chemoradiotherapy resistance via CAF stimulation in vitro and 5-fluorouracil (FU) resistance in CAF-coinoculated tumor models in vivo. CAF stimulation promoted the migration/invasion of cancer cells and a stem-like phenotype in vitro, which were rescued by elimination of CAF stimulation. CAFs-PIT had a highly selective effect on CAFs in vitro. Finally, CAF elimination by CAFs-PIT in vivo demonstrated that the combination of 5-FU and NIR-PIT succeeded in producing 70.9% tumor reduction, while 5-FU alone achieved only 13.3% reduction, suggesting the recovery of 5-FU sensitivity in CAF-rich tumors. In conclusion, CAFs-PIT could overcome therapeutic resistance via CAF elimination. The combined use of novel targeted CAFs-PIT with conventional anticancer treatments can be expected to provide a more effective and sensible treatment strategy.

Gold nanoparticle-enhanced near infrared fluorescent nanocomposites for targeted bio-imaging

RSC Advances ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Hao Cheng ◽  
Chuanxi Wang ◽  
Zhenzhu Xu ◽  
Huihui Lin ◽  
Chi Zhang
Keyword(s):  
Folic Acid ◽  
Cancer Cells ◽  
Gold Nanoparticle ◽  
Near Infrared ◽  
Water Solubility ◽  
Imaging Agents ◽  
Nir Fluorescence ◽  
Target Imaging ◽  
Bio Imaging ◽  
Low Toxicity

Folic acid-conjugated nanocomposites with NIR fluorescence, water-solubility, and low toxicity are prepared and used as target-imaging agents for cancer cells.

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