scholarly journals The association of the cytoplasmic domains of interleukin 4 receptor alpha and interleukin 13 receptor alpha 2 regulates interleukin 4 signaling

2013 ◽  
Vol 9 (12) ◽  
pp. 3009 ◽  
Author(s):  
Allison-Lynn Andrews ◽  
Ida Karin Nordgren ◽  
Gemma Campbell-Harding ◽  
John W. Holloway ◽  
Stephen T. Holgate ◽  
...  
Keyword(s):  
Interleukin 4 ◽  
Cytoplasmic Domains ◽  
Receptor Alpha ◽  
Interleukin 13 ◽  
Interleukin 4 Receptor

scholarly journals IL-4R alpha deficiency influences hippocampal-BDNF signaling pathway to impair reference memory

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
T. M. Brombacher ◽  
I. Berkiks ◽  
S. Pillay ◽  
M. Scibiorek ◽  
B. O. Moses ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Inflammatory Cytokines ◽  
Chain Complex ◽  
Reference Memory ◽  
Spatial Task ◽  
Interleukin 4 ◽  
Receptor Alpha ◽  
Interleukin 13 ◽  
Interleukin 4 Receptor ◽  
Deficient Mice

Abstract Like pro-inflammatory cytokines, the role of anti-inflammatory cytokines in both learning and memory has been investigated, revealing beneficial effects for both interleukin-4 and interleukin-13 via the common interleukin-4 receptor alpha chain complex. In this study, using the Morris water maze spatial task for cognition, we compared interleukin-4 receptor alpha- deficient mice and their ligands interleukin-4/ interleukin-13 double deficient mice, on a Balb/c background. We demonstrate that while interleukin-4/ interleukin-13 double deficient mice are significantly impaired in both learning and reference memory, interleukin-4 receptor alpha-deficiency impairs only reference memory, compared to the wild-type control mice. In order to better understand how interleukin-4 receptor alpha- deficient mice are able to learn but not remember, we investigated the BDNF/TrkB- and the ARC-signaling pathways. We show that interleukin-4 receptor alpha-deficiency disrupts activation of BDNF/TrkB- and ARC-signaling pathways during reference memory, while the pathway for spatial learning is spared.

The influence of interleukin-13/interleukin-4 receptor-alpha signaling in the pathology of tuberculosis

Pneumologie ◽  
2010 ◽  
Vol 64 (01) ◽  
Author(s):  
L Heitmann ◽  
T Schreiber ◽  
T Thye ◽  
ANJ Mckenzie ◽  
F Brombacher ◽  
...  
Keyword(s):  
Interleukin 4 ◽  
Receptor Alpha ◽  
Interleukin 13 ◽  
Interleukin 4 Receptor

scholarly journals Interleukin-4 Receptor Alpha Expressing B Cells Are Essential to Down-Modulate Host Granulomatous Inflammation During Schistosomasis

2018 ◽  
Vol 9 ◽  
Author(s):  
Hlumani Ndlovu ◽  
Justin Komguep Nono ◽  
Nada Abdel Aziz ◽  
Natalie Eva Nieuwenhuizen ◽  
Frank Brombacher
Keyword(s):  
B Cells ◽  
Granulomatous Inflammation ◽  
Interleukin 4 ◽  
Receptor Alpha ◽  
Interleukin 4 Receptor

scholarly journals Interleukin 13 and Interleukin 4 Receptor-α Polymorphisms in Rhinitis and Asthma

2010 ◽  
Vol 153 (3) ◽  
pp. 259-267 ◽  
Author(s):  
Renske W.B. Bottema ◽  
Ilja M. Nolte ◽  
Timothy D. Howard ◽  
Gerard H. Koppelman ◽  
Anthony E.J. Dubois ◽  
...  
Keyword(s):  
Interleukin 4 ◽  
Interleukin 13 ◽  
Interleukin 4 Receptor

scholarly journals IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha

2016 ◽  
Vol 46 (10) ◽  
pp. 2311-2321 ◽  
Author(s):  
Lucy H. Jackson-Jones ◽  
Dominik Rückerl ◽  
Freya Svedberg ◽  
Sheelagh Duncan ◽  
Rick M. Maizels ◽  
...  
Keyword(s):  
Interleukin 4 ◽  
Receptor Alpha ◽  
Interleukin 4 Receptor

Characterization and Comparison of the Interleukin 13 Receptor with the Interleukin 4 Receptor on Several Cell Types

1995 ◽  
Vol 270 (8) ◽  
pp. 3512-3517 ◽  
Author(s):  
Natalio Vita ◽  
Sylvie Lefort ◽  
Patrick Laurent ◽  
Daniel Caput ◽  
Pascual Ferrara
Keyword(s):  
Cell Types ◽  
Interleukin 4 ◽  
Interleukin 13 ◽  
Interleukin 4 Receptor

scholarly journals Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor.

1996 ◽  
Vol 93 (1) ◽  
pp. 497-501 ◽  
Author(s):  
D. J. Hilton ◽  
J. G. Zhang ◽  
D. Metcalf ◽  
W. S. Alexander ◽  
N. A. Nicola ◽  
...  
Keyword(s):  
Interleukin 4 ◽  
Interleukin 13 ◽  
Interleukin 4 Receptor ◽  
Binding Subunit
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