scholarly journals Interleukin 13 and Interleukin 4 Receptor-α Polymorphisms in Rhinitis and Asthma

2010 ◽  
Vol 153 (3) ◽  
pp. 259-267 ◽  
Author(s):  
Renske W.B. Bottema ◽  
Ilja M. Nolte ◽  
Timothy D. Howard ◽  
Gerard H. Koppelman ◽  
Anthony E.J. Dubois ◽  
...  
Keyword(s):  
Interleukin 4 ◽  
Interleukin 13 ◽  
Interleukin 4 Receptor

Characterization and Comparison of the Interleukin 13 Receptor with the Interleukin 4 Receptor on Several Cell Types

1995 ◽  
Vol 270 (8) ◽  
pp. 3512-3517 ◽  
Author(s):  
Natalio Vita ◽  
Sylvie Lefort ◽  
Patrick Laurent ◽  
Daniel Caput ◽  
Pascual Ferrara
Keyword(s):  
Cell Types ◽  
Interleukin 4 ◽  
Interleukin 13 ◽  
Interleukin 4 Receptor

scholarly journals Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor.

1996 ◽  
Vol 93 (1) ◽  
pp. 497-501 ◽  
Author(s):  
D. J. Hilton ◽  
J. G. Zhang ◽  
D. Metcalf ◽  
W. S. Alexander ◽  
N. A. Nicola ◽  
...  
Keyword(s):  
Interleukin 4 ◽  
Interleukin 13 ◽  
Interleukin 4 Receptor ◽  
Binding Subunit

Type I IgE receptor, interleukin 4 receptor and interleukin 13 polymorphisms in children with nephrotic syndrome

2002 ◽  
Vol 102 (5) ◽  
pp. 507 ◽  
Author(s):  
K. TENBROCK ◽  
A. SCHUBERT ◽  
L. STAPENHORST ◽  
M. J. KEMPER ◽  
J. GELLERMANN ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Interleukin 4 ◽  
Type I ◽  
Ige Receptor ◽  
Interleukin 13 ◽  
Interleukin 4 Receptor

scholarly journals Association analysis of non-synonymous polymorphisms of interleukin-4 receptor-α and interleukin-13 genes in canine atopic dermatitis

2020 ◽  
Vol 82 (9) ◽  
pp. 1253-1259
Author(s):  
Kazuaki TANAKA ◽  
Misaki YAMAMOTO-FUKUDA ◽  
Tatsuya TAKIZAWA ◽  
Hidekatsu SHIMAKURA ◽  
Masahiro SAKAGUCHI
Keyword(s):  
Atopic Dermatitis ◽  
Association Analysis ◽  
Interleukin 4 ◽  
Canine Atopic Dermatitis ◽  
Interleukin 13 ◽  
Interleukin 4 Receptor

scholarly journals The association of the cytoplasmic domains of interleukin 4 receptor alpha and interleukin 13 receptor alpha 2 regulates interleukin 4 signaling

2013 ◽  
Vol 9 (12) ◽  
pp. 3009 ◽  
Author(s):  
Allison-Lynn Andrews ◽  
Ida Karin Nordgren ◽  
Gemma Campbell-Harding ◽  
John W. Holloway ◽  
Stephen T. Holgate ◽  
...  
Keyword(s):  
Interleukin 4 ◽  
Cytoplasmic Domains ◽  
Receptor Alpha ◽  
Interleukin 13 ◽  
Interleukin 4 Receptor

Polymorphisms in the interleukin 4, interleukin 4 receptor and interleukin 13 genes and allergic phenotype: A case control study

2016 ◽  
Vol 61 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Beata Narożna ◽  
Aleksandra Hoffmann ◽  
Paulina Sobkowiak ◽  
Natalia Schoneich ◽  
Anna Bręborowicz ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Interleukin 4 ◽  
Interleukin 13 ◽  
Interleukin 4 Receptor ◽  
Control Study

scholarly journals IL-4R alpha deficiency influences hippocampal-BDNF signaling pathway to impair reference memory

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
T. M. Brombacher ◽  
I. Berkiks ◽  
S. Pillay ◽  
M. Scibiorek ◽  
B. O. Moses ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Inflammatory Cytokines ◽  
Chain Complex ◽  
Reference Memory ◽  
Spatial Task ◽  
Interleukin 4 ◽  
Receptor Alpha ◽  
Interleukin 13 ◽  
Interleukin 4 Receptor ◽  
Deficient Mice

Abstract Like pro-inflammatory cytokines, the role of anti-inflammatory cytokines in both learning and memory has been investigated, revealing beneficial effects for both interleukin-4 and interleukin-13 via the common interleukin-4 receptor alpha chain complex. In this study, using the Morris water maze spatial task for cognition, we compared interleukin-4 receptor alpha- deficient mice and their ligands interleukin-4/ interleukin-13 double deficient mice, on a Balb/c background. We demonstrate that while interleukin-4/ interleukin-13 double deficient mice are significantly impaired in both learning and reference memory, interleukin-4 receptor alpha-deficiency impairs only reference memory, compared to the wild-type control mice. In order to better understand how interleukin-4 receptor alpha- deficient mice are able to learn but not remember, we investigated the BDNF/TrkB- and the ARC-signaling pathways. We show that interleukin-4 receptor alpha-deficiency disrupts activation of BDNF/TrkB- and ARC-signaling pathways during reference memory, while the pathway for spatial learning is spared.

Sign in / Sign up

Export Citation Format

Share Document