scholarly journals IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha

2016 ◽  
Vol 46 (10) ◽  
pp. 2311-2321 ◽  
Author(s):  
Lucy H. Jackson-Jones ◽  
Dominik Rückerl ◽  
Freya Svedberg ◽  
Sheelagh Duncan ◽  
Rick M. Maizels ◽  
...  
Keyword(s):  
Interleukin 4 ◽  
Receptor Alpha ◽  
Interleukin 4 Receptor

scholarly journals Interleukin-4 Receptor Alpha Expressing B Cells Are Essential to Down-Modulate Host Granulomatous Inflammation During Schistosomasis

2018 ◽  
Vol 9 ◽  
Author(s):  
Hlumani Ndlovu ◽  
Justin Komguep Nono ◽  
Nada Abdel Aziz ◽  
Natalie Eva Nieuwenhuizen ◽  
Frank Brombacher
Keyword(s):  
B Cells ◽  
Granulomatous Inflammation ◽  
Interleukin 4 ◽  
Receptor Alpha ◽  
Interleukin 4 Receptor

IN VIVO EXPRESSION OF THE INTERLEUKIN 4 RECEPTOR ALPHA BY ASTROCYTES IN EPILEPSY CEREBRAL CORTEX

Cytokine ◽  
2000 ◽  
Vol 12 (11) ◽  
pp. 1656-1661 ◽  
Author(s):  
Haiyan Liu ◽  
Richard A Prayson ◽  
Melinda L Estes ◽  
Judith A Drazba ◽  
Gene H Barnett ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Interleukin 4 ◽  
Receptor Alpha ◽  
In Vivo Expression ◽  
Interleukin 4 Receptor

Interleukin-4 and Interleukin-4 Receptor Alpha Gene Polymorphisms in Recurrent Aphthous Stomatitis

2018 ◽  
Vol 47 (7) ◽  
pp. 680-688
Author(s):  
Shamsolmoulouk Najafi ◽  
Mahsa Mohammadzadeh ◽  
Fateme Rajabi ◽  
Alireza Zare Bidoki ◽  
Hila Yousefi ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Interleukin 4 ◽  
Receptor Alpha ◽  
Alpha Gene ◽  
Interleukin 4 Receptor

scholarly journals Anisakis pegreffii-Induced Airway Hyperresponsiveness Is Mediated by Gamma Interferon in the Absence of Interleukin-4 Receptor Alpha Responsiveness

2010 ◽  
Vol 78 (9) ◽  
pp. 4077-4086 ◽  
Author(s):  
Frank Kirstein ◽  
William G. C. Horsnell ◽  
Natalie Nieuwenhuizen ◽  
Bernhard Ryffel ◽  
Andreas L. Lopata ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Airway Hyperresponsiveness ◽  
Allergic Airway Inflammation ◽  
Gamma Interferon ◽  
Interleukin 4 ◽  
Wild Type ◽  
Receptor Alpha ◽  
Immunological Mechanisms ◽  
Ifn Γ ◽  
Interleukin 4 Receptor

ABSTRACT Infection with the fish parasite Anisakis following exposure to contaminated fish can lead to allergic reactions in humans. The present study examined the immunological mechanisms underlying the development of allergic airway inflammation in mice after different routes of sensitization to Anisakis. Wild-type and interleukin-4 receptor alpha (IL-4Rα)-deficient BALB/c mice were sensitized intraperitoneally with live or heat-killed Anisakis larvae or by intranasal administration of an Anisakis extract and were subsequently challenged intranasally with an Anisakis extract. Both routes of sensitization induced IL-4Rα-dependent allergic airway responses, whereas allergen-specific antibody responses developed only when mice were sensitized intraperitoneally. Intranasal sensitization induced airway hyperresponsiveness (AHR) in wild-type mice only, showing that AHR was IL-4/IL-13 dependent. Unexpectedly, infection with Anisakis larvae induced AHR in both wild-type and IL-4Rα-deficient mice. IL-4Rα-independent AHR was mediated by gamma interferon (IFN-γ), as evidenced by the fact that in vivo neutralization of IFN-γ abrogated AHR. Together, these results demonstrate that both infection with larvae and inhalational exposure to Anisakis proteins are potent routes of allergic sensitization to Anisakis, explaining food- and work-related allergies in humans. Importantly for diagnosis, allergic airway inflammation can be independent of detectable Anisakis-specific antibodies. Moreover, depending on the route of sensitization, AHR can be induced either by IL-4/IL-13 or by IFN-γ.

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