Magneto-optical nanomaterials: a SPIO–phthalocyanine scaffold built step-by-step towards bimodal imaging

2013 ◽  
Vol 49 (67) ◽  
pp. 7394 ◽  
Author(s):  
Julien Boudon ◽  
Jérémy Paris ◽  
Yann Bernhard ◽  
Elena Popova ◽  
Richard A. Decréau ◽  
...  
Keyword(s):  
Bimodal Imaging ◽  
Optical Nanomaterials

scholarly journals MSCs-engineered biomimetic PMAA nanomedicines for multiple bioimaging-guided and photothermal-enhanced radiotherapy of NSCLC

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Yipengchen Yin ◽  
Yongjing Li ◽  
Sheng Wang ◽  
Ziliang Dong ◽  
Chao Liang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Membranes ◽  
Imaging System ◽  
Fluorescence Signal ◽  
Bimodal Imaging ◽  
Red Blood Cell Membranes ◽  
Magnetic Resonance Imaging Mri ◽  
Tumor Accumulation

Abstract Background The recently developed biomimetic strategy is one of the mostly effective strategies for improving the theranostic efficacy of diverse nanomedicines, because nanoparticles coated with cell membranes can disguise as “self”, evade the surveillance of the immune system, and accumulate to the tumor sites actively. Results Herein, we utilized mesenchymal stem cell memabranes (MSCs) to coat polymethacrylic acid (PMAA) nanoparticles loaded with Fe(III) and cypate—an derivative of indocyanine green to fabricate Cyp-PMAA-Fe@MSCs, which featured high stability, desirable tumor-accumulation and intriguing photothermal conversion efficiency both in vitro and in vivo for the treatment of lung cancer. After intravenous administration of Cyp-PMAA-Fe@MSCs and Cyp-PMAA-Fe@RBCs (RBCs, red blood cell membranes) separately into tumor-bearing mice, the fluorescence signal in the MSCs group was 21% stronger than that in the RBCs group at the tumor sites in an in vivo fluorescence imaging system. Correspondingly, the T1-weighted magnetic resonance imaging (MRI) signal at the tumor site decreased 30% after intravenous injection of Cyp-PMAA-Fe@MSCs. Importantly, the constructed Cyp-PMAA-Fe@MSCs exhibited strong photothermal hyperthermia effect both in vitro and in vivo when exposed to 808 nm laser irradiation, thus it could be used for photothermal therapy. Furthermore, tumors on mice treated with phototermal therapy and radiotherapy shrank 32% more than those treated with only radiotherapy. Conclusions These results proved that Cyp-PMAA-Fe@MSCs could realize fluorescence/MRI bimodal imaging, while be used in phototermal-therapy-enhanced radiotherapy, providing desirable nanoplatforms for tumor diagnosis and precise treatment of non-small cell lung cancer.

scholarly journals Design and Synthesis of Luminescent Lanthanide-Based Bimodal Nanoprobes for Dual Magnetic Resonance (MR) and Optical Imaging

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 354
Author(s):  
Walid Mnasri ◽  
Mahsa Parvizian ◽  
Souad Ammar-Merah
Keyword(s):  
Magnetic Resonance ◽  
Optical Imaging ◽  
Imaging Technique ◽  
Imaging Techniques ◽  
Design And Synthesis ◽  
Bimodal Imaging ◽  
Successive Image ◽  
Complete Set ◽  
Magnetic Resonance Imaging Mri ◽  
Physical And Chemical

Current biomedical imaging techniques are crucial for the diagnosis of various diseases. Each imaging technique uses specific probes that, although each one has its own merits, do not encompass all the functionalities required for comprehensive imaging (sensitivity, non-invasiveness, etc.). Bimodal imaging methods are therefore rapidly becoming an important topic in advanced healthcare. This bimodality can be achieved by successive image acquisitions involving different and independent probes, one for each mode, with the risk of artifacts. It can be also achieved simultaneously by using a single probe combining a complete set of physical and chemical characteristics, in order to record complementary views of the same biological object at the same time. In this scenario, and focusing on bimodal magnetic resonance imaging (MRI) and optical imaging (OI), probes can be engineered by the attachment, more or less covalently, of a contrast agent (CA) to an organic or inorganic dye, or by designing single objects containing both the optical emitter and MRI-active dipole. If in the first type of system, there is frequent concern that at some point the dye may dissociate from the magnetic dipole, it may not in the second type. This review aims to present a summary of current activity relating to this kind of dual probes, with a special emphasis on lanthanide-based luminescent nano-objects.

Energy transfer-based biodetection using optical nanomaterials

2018 ◽  
Vol 6 (19) ◽  
pp. 2924-2944 ◽  
Author(s):  
Bing Chen ◽  
Qianqian Su ◽  
Wei Kong ◽  
Yuan Wang ◽  
Peng Shi ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Recent Progress ◽  
Sensing Systems ◽  
Optical Nanomaterials

This review focuses on recent progress in the development of FRET probes and the applications of FRET-based sensing systems.

Gadolinium(III)-Based Porous Luminescent Metal-Organic Frameworks for Bimodal Imaging

ChemPlusChem ◽  
2016 ◽  
Vol 81 (8) ◽  
pp. 728-732 ◽  
Author(s):  
Tanay Kundu ◽  
Shouvik Mitra ◽  
David Díaz Díaz ◽  
Rahul Banerjee
Keyword(s):  
Metal Organic Frameworks ◽  
Bimodal Imaging ◽  
Metal Organic

A light-controllable specific drug delivery nanoplatform for targeted bimodal imaging-guided photothermal/chemo synergistic cancer therapy

2018 ◽  
Vol 80 ◽  
pp. 308-326 ◽  
Author(s):  
Yuan Guo ◽  
Xing-Yue Wang ◽  
Yu-Li Chen ◽  
Feng-Qiu Liu ◽  
Mi-Xiao Tan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Specific Drug ◽  
Bimodal Imaging

scholarly journals Bimodal imaging and beyond

2016 ◽  
Vol 254 ◽  
pp. 307-308
Author(s):  
Hans-Peter Deigner
Keyword(s):  
Bimodal Imaging

scholarly journals Ultralong tumor retention of theranostic nanoparticles with short peptide-enabled active tumor homing

2019 ◽  
Vol 6 (9) ◽  
pp. 1845-1853 ◽  
Author(s):  
Lihua Li ◽  
Yao Lu ◽  
Zefeng Lin ◽  
Angelina S. Mao ◽  
Ju Jiao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Tumor ◽  
Short Peptide ◽  
Highly Efficient ◽  
Bimodal Imaging ◽  
Theranostic Nanoparticles ◽  
Tumor Homing ◽  
Homing Peptide ◽  
Tumor Retention

A short breast tumor-homing peptide can guide the theranostic nanoparticles to the tumors and enable their ultralong tumor retention, leading to highly efficient targeted breast cancer CT/MRI bimodal imaging and photothermal-chemotherapy.

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