Synthesis, biological evaluation, and structure–activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors

Jessy Aziz; Etienne Brachet; Abdallah Hamze; Jean-François Peyrat; Guillaume Bernadat; Estelle Morvan; Jérôme Bignon; Joanna Wdzieczak-Bakala; Déborah Desravines; Joelle Dubois; Marie Tueni; Ahmad Yassine; Jean-Daniel Brion; Mouad Alami

doi:10.1039/c2ob26253c

Synthesis, biological evaluation, and structure–activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors

Organic & Biomolecular Chemistry ◽

10.1039/c2ob26253c ◽

2013 ◽

Vol 11 (3) ◽

pp. 430-442 ◽

Cited By ~ 34

Author(s):

Jessy Aziz ◽

Etienne Brachet ◽

Abdallah Hamze ◽

Jean-François Peyrat ◽

Guillaume Bernadat ◽

...

Keyword(s):

Biological Evaluation ◽

Tubulin Inhibitors ◽

Structure Activity Relationships ◽

Structure Activity ◽

Tetrasubstituted Olefins

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Design, Synthesis, Biological Evaluation, and Structure–Activity Relationships of Substituted Phenyl 4-(2-Oxoimidazolidin-1-yl)benzenesulfonates as New Tubulin Inhibitors Mimicking Combretastatin A-4

Journal of Medicinal Chemistry ◽

10.1021/jm200488a ◽

2011 ◽

Vol 54 (13) ◽

pp. 4559-4580 ◽

Cited By ~ 34

Author(s):

Sébastien Fortin ◽

Lianhu Wei ◽

Emmanuel Moreau ◽

Jacques Lacroix ◽

Marie-France Côté ◽

...

Keyword(s):

Biological Evaluation ◽

Design Synthesis ◽

Tubulin Inhibitors ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 18.1N-Substituted 14-Phenylpropyloxymorphinan-6-ones with Unanticipated Agonist Properties: Extending the Scope of Common Structure−Activity Relationships

Journal of Medicinal Chemistry ◽

10.1021/jm021118o ◽

2003 ◽

Vol 46 (9) ◽

pp. 1758-1763 ◽

Cited By ~ 23

Author(s):

Elisabeth Greiner ◽

Mariana Spetea ◽

Roland Krassnig ◽

Falko Schüllner ◽

Mario Aceto ◽

...

Keyword(s):

Biological Evaluation ◽

Structure Activity Relationships ◽

Common Structure ◽

Structure Activity ◽

Synthesis And Biological Evaluation

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125 Synthesis, biological evaluation and structure activity relationships of a novel servies of aromatic hydroxamic acids as potent HDAC inhibitors

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(04)80133-2 ◽

2004 ◽

Vol 2 (8) ◽

pp. 40-41

Author(s):

K. Van Emelen ◽

J. Arts ◽

P. Angibaud ◽

H. De Winter ◽

S. Van Brandt ◽

...

Keyword(s):

Hdac Inhibitors ◽

Hydroxamic Acids ◽

Biological Evaluation ◽

Structure Activity Relationships ◽

Structure Activity

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Biological Evaluation, Structure−Activity Relationships, and Three-Dimensional Quantitative Structure−Activity Relationship Studies of Dihydro-β-agarofuran Sesquiterpenes as Modulators of P-Glycoprotein-Dependent Multidrug Resistance

Journal of Medicinal Chemistry ◽

10.1021/jm070290v ◽

2007 ◽

Vol 50 (20) ◽

pp. 4808-4817 ◽

Cited By ~ 30

Author(s):

Carolina P. Reyes ◽

Francisco Muñoz-Martínez ◽

Ivan R. Torrecillas ◽

Cristina R. Mendoza ◽

Francisco Gamarro ◽

...

Keyword(s):

Multidrug Resistance ◽

Three Dimensional ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Biological Evaluation ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

P Glycoprotein

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Selective and effective anticancer agents: Synthesis, biological evaluation and structure-activity relationships of novel carbazole derivatives

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.104991 ◽

2021 ◽

pp. 104991

Author(s):

Wenbo Huang ◽

Zilin Gao ◽

Zhigang Zhang ◽

Wei Fang ◽

Zuoqian Wang ◽

...

Keyword(s):

Anticancer Agents ◽

Biological Evaluation ◽

Carbazole Derivatives ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis, Biological Evaluation, and Structure−Activity Relationships of 3-Acylindole-2-carboxylic Acids as Inhibitors of the Cytosolic Phospholipase A2

Journal of Medicinal Chemistry ◽

10.1021/jm960863w ◽

1997 ◽

Vol 40 (17) ◽

pp. 2694-2705 ◽

Cited By ~ 20

Author(s):

Matthias Lehr

Keyword(s):

Phospholipase A2 ◽

Carboxylic Acids ◽

Biological Evaluation ◽

Cytosolic Phospholipase A2 ◽

Structure Activity Relationships ◽

Cytosolic Phospholipase ◽

Structure Activity

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Taxol structure-activity relationships: synthesis and biological evaluation of 10-deoxytaxol

The Journal of Organic Chemistry ◽

10.1021/jo00063a001 ◽

1993 ◽

Vol 58 (11) ◽

pp. 2927-2928 ◽

Cited By ~ 32

Author(s):

Shu Hui Chen ◽

Craig Fairchild ◽

Stephen W. Mamber ◽

Vittorio Farina

Keyword(s):

Biological Evaluation ◽

Structure Activity Relationships ◽

Structure Activity ◽

Synthesis And Biological Evaluation

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New platinum(II) complexes conjugated at position 7α of 17β-acetyl-testosterone as new combi-molecules against prostate cancer: Design, synthesis, structure–activity relationships and biological evaluation

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2013.08.011 ◽

2013 ◽

Vol 68 ◽

pp. 433-443 ◽

Cited By ~ 20

Author(s):

Sébastien Fortin ◽

Kevin Brasseur ◽

Nathalie Morin ◽

Éric Asselin ◽

Gervais Bérubé

Keyword(s):

Prostate Cancer ◽

Biological Evaluation ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis, biological evaluation and structure–activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.03.081 ◽

2012 ◽

Vol 22 (10) ◽

pp. 3473-3479 ◽

Cited By ~ 21

Author(s):

Li-Jun Wang ◽

Chang-An Geng ◽

Yun-Bao Ma ◽

Xiao-Yan Huang ◽

Jie Luo ◽

...

Keyword(s):

Hepatitis B Virus ◽

Hepatitis B ◽

Biological Evaluation ◽

Glycyrrhetinic Acid ◽

Structure Activity Relationships ◽

Structure Activity ◽

B Virus

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5-Cinnamoyl-6-aminouracil derivatives as novel anticancer agents. Synthesis, biological evaluation, and structure-activity relationships

Journal of Medicinal Chemistry ◽

10.1021/jm00382a020 ◽

1985 ◽

Vol 28 (4) ◽

pp. 497-502 ◽

Cited By ~ 20

Author(s):

Jean Luc Bernier ◽

Jean Pierre Henichart ◽

Vincent Warin ◽

Chantal Trentesaux ◽

Jean Claude Jardillier

Keyword(s):

Anticancer Agents ◽

Biological Evaluation ◽

Structure Activity Relationships ◽

Structure Activity

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