scholarly journals Design, Synthesis, Biological Evaluation, and Structure–Activity Relationships of Substituted Phenyl 4-(2-Oxoimidazolidin-1-yl)benzenesulfonates as New Tubulin Inhibitors Mimicking Combretastatin A-4

2011 ◽  
Vol 54 (13) ◽  
pp. 4559-4580 ◽  
Author(s):  
Sébastien Fortin ◽  
Lianhu Wei ◽  
Emmanuel Moreau ◽  
Jacques Lacroix ◽  
Marie-France Côté ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Tubulin Inhibitors ◽  
Structure Activity Relationships ◽  
Structure Activity

1,5-Benzodiazepine derivatives as potential antimicrobial agents: design, synthesis, biological evaluation, and structure–activity relationships

2015 ◽  
Vol 13 (19) ◽  
pp. 5497-5509 ◽  
Author(s):  
Lan-Zhi Wang ◽  
Xiao-Qing Li ◽  
Ying-Shuang An
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Benzodiazepine Derivatives

36 novel 1,5-benzodiazepine derivatives were synthesized and evaluated for their in vitro antimicrobial activity. The results revealed that most of the 1,5-benzodiazepine derivatives exhibited considerable potency against all of the tested strains.

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