Biodegradable poly(ε-caprolactone)-g-poly(2-hydroxyethyl methacrylate) graft copolymer micelles as superior nano-carriers for “smart” doxorubicin release

2012 ◽  
Vol 22 (23) ◽  
pp. 11730 ◽  
Author(s):  
Ru Cheng ◽  
Xiaoyan Wang ◽  
Wei Chen ◽  
Fenghua Meng ◽  
Chao Deng ◽  
...  
Keyword(s):  
Graft Copolymer ◽  
Hydroxyethyl Methacrylate ◽  
Biodegradable Poly ◽  
Copolymer Micelles ◽  
Doxorubicin Release

scholarly journals Poly(amino acid)-polyester graft copolymer nanoparticles for the acid-mediated release of doxorubicin

2017 ◽  
Vol 53 (62) ◽  
pp. 8687-8690 ◽  
Author(s):  
Daniel J. Price ◽  
Mthulisi Khuphe ◽  
Robert P. W. Davies ◽  
James R. McLaughlan ◽  
Nicola Ingram ◽  
...  
Keyword(s):  
Amino Acid ◽  
Graft Copolymer ◽  
Ring Opening ◽  
Ph Responsive ◽  
Doxorubicin Release

OCA and NCA ring-opening polymerisations are combined to yield pH-responsive nanoparticles ideally suited for controlled doxorubicin release.

Disulfide cross-linked cholic-acid modified PEG–poly(amino acid) block copolymer micelles for controlled drug delivery of doxorubicin

RSC Advances ◽  
2015 ◽  
Vol 5 (38) ◽  
pp. 30380-30388 ◽  
Author(s):  
Yuling Li ◽  
Yuling Shen ◽  
Sai Wang ◽  
Dandan Zhu ◽  
Baixiang Du ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Amino Acid ◽  
Block Copolymer ◽  
Cholic Acid ◽  
Controlled Drug Delivery ◽  
Poly Ethylene Glycol ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles ◽  
Poly Ethylene ◽  
Doxorubicin Release

Reduction responsive biodegradable core-cross-linked micelles are developed form lipoic acid and cholic acid decorated poly(ethylene glycol)-b-poly(l-glutamic acid) block copolymers and investigated for intracellular doxorubicin release.

Syntheses and interfacial characterization of graft copolymers from styrene and 2-hydroxyethyl methacrylate that comprise either trunks or branches

1995 ◽  
Vol 73 (11) ◽  
pp. 1757-1764 ◽  
Author(s):  
Hidekazu Yoshida ◽  
Shinichi Itsuno ◽  
Koichi. Ito
Keyword(s):  
Graft Copolymer ◽  
Graft Copolymers ◽  
Micelle Formation ◽  
Hydroxyethyl Methacrylate ◽  
H Nmr ◽  
Copolymer Films ◽  
Angle Measurements ◽  
Contact Angle Measurements ◽  
Copolymer Micelle ◽  
End Capping

Polystyrene (PS) and poly(2-hydroxyethyl methacrylate) (PHEMA) macromonomers with either p-vinylbenzyl or methacrylate end groups were prepared by living anionic polymerizations of styrene and 2-(trimethylsilyloxy)ethyl methacrylate, respectively, followed by appropriate end-capping. They were radically copolymerized with 2-hydroxyethyl methacrylate and styrene, respectively, to afford PS-g-PHEMA and PHEMA-g-PS, having PS trunks with PHEMA branches or the reverse architecture. 1H NMR spectra of the graft copolymers in deuterated methanol showed their micelle formation with PS and PHEMA chains as the core and the shell, respectively. In chloroform the reverse micelles were observed. Contact angle measurements of water on the graft copolymer films revealed that PS chains were generally dominant on the free surface. The films either cast from methanol or after immersion into water, however, were apparently wettable, indicating dominant PHEMA chains on the surface. Keywords: styrene, 2-hydroxyethyl methacrylate, graft copolymer, micelle formation, wettability.

Biocompatible and bioreducible micelles fabricated from novel α-amino acid-based poly(disulfide urethane)s: design, synthesis and triggered doxorubicin release

2015 ◽  
Vol 6 (33) ◽  
pp. 6001-6010 ◽  
Author(s):  
Wentao Lu ◽  
Xiuxiu Wang ◽  
Ru Cheng ◽  
Chao Deng ◽  
Fenghua Meng ◽  
...  
Keyword(s):  
Amino Acid ◽  
Drug Release ◽  
Triblock Copolymer ◽  
Release Behavior ◽  
Design Synthesis ◽  
Drug Release Behavior ◽  
Reductive Degradation ◽  
Good Biocompatibility ◽  
Copolymer Micelles ◽  
Doxorubicin Release

Novel α-amino acid-based poly(disulfide urethane)s have been developed for the construction of smart triblock copolymer micelles that show good biocompatibility, fast reductive degradation, and triggered intracellular drug release behavior.

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