scholarly journals Poly(amino acid)-polyester graft copolymer nanoparticles for the acid-mediated release of doxorubicin

2017 ◽  
Vol 53 (62) ◽  
pp. 8687-8690 ◽  
Author(s):  
Daniel J. Price ◽  
Mthulisi Khuphe ◽  
Robert P. W. Davies ◽  
James R. McLaughlan ◽  
Nicola Ingram ◽  
...  
Keyword(s):  
Amino Acid ◽  
Graft Copolymer ◽  
Ring Opening ◽  
Ph Responsive ◽  
Doxorubicin Release

OCA and NCA ring-opening polymerisations are combined to yield pH-responsive nanoparticles ideally suited for controlled doxorubicin release.

Diversity-Oriented Synthesis of Highly Functionalized Alicycles across Dipolar Cycloaddition/Metathesis Reaction

Synlett ◽  
2021 ◽  
Author(s):  
Loránd Kiss ◽  
Zsanett Benke ◽  
Melinda Nonn ◽  
Attila M. Remete ◽  
Santos Fustero
Keyword(s):  
Amino Acid ◽  
Ring Opening ◽  
Nitrile Oxide ◽  
Amino Acid Derivatives ◽  
Selective Synthesis ◽  
Chemical Transformations ◽  
Bond Functionalization ◽  
Cross Metathesis ◽  
Chlorosulfonyl Isocyanate ◽  
Biological Potential

AbstractThis Account gives an insight into the selective functionalization of some readily available commercial cyclodienes across simple chemical transformations into functionalized small-molecular scaffolds. The syntheses involved selective cycloadditions, followed by ring-opening metathesis (ROM) of the resulting azetidin-2-one derivatives or isoxazoline frameworks and selective cross metathesis (CM) by discrimination of the C=C bonds on the alkenylated heterocycles. The CM protocols have been described when investigated under various conditions with the purpose on exploring chemodifferentiation of the olefin bonds and a study on the access of the corresponding functionalized β-lactam or isoxazoline derivatives is presented. Due to the expanding importance of organofluorine chemistry in drug research as well as of the high biological potential of β-lactam derivatives several illustrative examples to the access of some fluorine-containing molecular entities is also presented in this synopsis.1 Introduction2 Ring C=C Bond Functionalization of Some Cycloalkene β-Amino Acid Derivatives across Chlorosulfonyl Isocyanate Cycloaddition3 Ring C=C Bond Functionalization of Some Cycloalkene β-Amino Acid Derivatives across Nitrile Oxide Cycloaddition4 Ring C=C Bond Functionalization of Some Cycloalkene β-Amino Acid Derivatives across Metathesis5 Functionalization of sSome Cyclodienes across Nitrile Oxide Cycloaddition6 Selective Synthesis of Functionalized Alicycles across Ring-Opening Metathesis7 Selective Synthesis of Functionalized Alicycles through Cross Metathesis8 Summary and Outlook9 List of Abbreviations

Self-Assembly Thermodynamics of pH-Responsive Amino-Acid-Based Polymers with a Nonionic Surfactant

Langmuir ◽  
2014 ◽  
Vol 30 (38) ◽  
pp. 11307-11318 ◽  
Author(s):  
Anna Bogomolova ◽  
Sandro Keller ◽  
Johannes Klingler ◽  
Marian Sedlak ◽  
Dmytro Rak ◽  
...  
Keyword(s):  
Amino Acid ◽  
Nonionic Surfactant ◽  
Self Assembly ◽  
Ph Responsive

Synthesis of Unnatural C-2 Amino Acid Nucleosides Using NIS-Mediated Ring Opening of 1,2-Cyclopropane Carboxylated Sugar Derivatives

Synlett ◽  
2009 ◽  
Vol 2009 (03) ◽  
pp. 451-455
Author(s):  
Srinivasan Chandrasekaran ◽  
Shrutisagar Haveli ◽  
Sudipta Roy
Keyword(s):  
Amino Acid ◽  
Ring Opening ◽  
Sugar Derivatives

Environmentally responsive amino acid-bioconjugated dynamic covalent copolymer as a versatile scaffold for conjugation

RSC Advances ◽  
2015 ◽  
Vol 5 (39) ◽  
pp. 30456-30463 ◽  
Author(s):  
Lin Wang ◽  
Li Liu ◽  
Libin Wu ◽  
Lingzhi Liu ◽  
Xiaobei Wang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Oxidative Coupling ◽  
Click Reaction ◽  
Coupling Reaction ◽  
Ph Responsive ◽  
Oxidative Coupling Reaction ◽  
Environmentally Responsive

A tyrosine-conjugated biodynamer with thermo/pH-responsive and adaptive features is constructed and modified by tyrosine-click reaction and HRP-mediated oxidative coupling reaction.

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