Biocompatible and bioreducible micelles fabricated from novel α-amino acid-based poly(disulfide urethane)s: design, synthesis and triggered doxorubicin release

2015 ◽  
Vol 6 (33) ◽  
pp. 6001-6010 ◽  
Author(s):  
Wentao Lu ◽  
Xiuxiu Wang ◽  
Ru Cheng ◽  
Chao Deng ◽  
Fenghua Meng ◽  
...  
Keyword(s):  
Amino Acid ◽  
Drug Release ◽  
Triblock Copolymer ◽  
Release Behavior ◽  
Design Synthesis ◽  
Drug Release Behavior ◽  
Reductive Degradation ◽  
Good Biocompatibility ◽  
Copolymer Micelles ◽  
Doxorubicin Release

Novel α-amino acid-based poly(disulfide urethane)s have been developed for the construction of smart triblock copolymer micelles that show good biocompatibility, fast reductive degradation, and triggered intracellular drug release behavior.

Reversibly cross-linked poly(ethylene glycol)–poly(amino acid)s copolymer micelles: a promising approach to overcome the extracellular stability versus intracellular drug release challenge

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 20025-20034 ◽  
Author(s):  
Yuling Li ◽  
Sai Wang ◽  
Dandan Zhu ◽  
Yuling Shen ◽  
Baixiang Du ◽  
...  
Keyword(s):  
Amino Acid ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Lipoic Acid ◽  
Triblock Copolymer ◽  
Intracellular Delivery ◽  
Poly Ethylene Glycol ◽  
Copolymer Micelles ◽  
Poly Ethylene ◽  
Copolymer Poly

Reversibly shell cross-linked micelles based on a lipoic acid (LA) decorated triblock copolymer poly(ethylene glycol)-b-poly(γ-benzyl-l-glutamate)-b-poly(l-phenylalanine) have been developed for efficient intracellular delivery of DOX.

Biodegradable Thermogelling Hydrogel of P(CL-GL)-PEG-P(CL-GL) Triblock Copolymer: Degradation Drug Release Behavior

2009 ◽  
Vol 98 (8) ◽  
pp. 2603-2610 ◽  
Author(s):  
Zhiqiang Jiang, ◽  
Jianyuan Hao ◽  
Yujing You ◽  
Weiming Cao ◽  
Xianmo Deng
Keyword(s):  
Drug Release ◽  
Triblock Copolymer ◽  
Release Behavior ◽  
Drug Release Behavior

Control drug release behavior by highly stable and pH sensitive poly(N-vinylpyrrolidone)-block-poly(4-vinylpyridine) copolymer micelles

Polymer ◽  
2021 ◽  
Vol 213 ◽  
pp. 123329
Author(s):  
Avnish Kumar Mishra ◽  
Junsub Lim ◽  
Jaeyong Lee ◽  
Soyeong Park ◽  
Yeseong Seo ◽  
...  
Keyword(s):  
Drug Release ◽  
Ph Sensitive ◽  
Release Behavior ◽  
Control Drug ◽  
Drug Release Behavior ◽  
Copolymer Micelles ◽  
Control Drug Release

scholarly journals Nanoformulation and Evaluation of Oral Berberine-Loaded Liposomes

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2591
Author(s):  
Thuan Thi Duong ◽  
Antti Isomäki ◽  
Urve Paaver ◽  
Ivo Laidmäe ◽  
Arvo Tõnisoo ◽  
...  
Keyword(s):  
Thin Film ◽  
Drug Release ◽  
Size Distribution ◽  
Water Soluble ◽  
Release Behavior ◽  
Uniform Size ◽  
Ethanol Injection ◽  
Drug Release Behavior ◽  
Poorly Water Soluble

Berberine (BBR) is a poorly water-soluble quaternary isoquinoline alkaloid of plant origin with potential uses in the drug therapy of hypercholesterolemia. To tackle the limitations associated with the oral therapeutic use of BBR (such as a first-pass metabolism and poor absorption), BBR-loaded liposomes were fabricated by ethanol-injection and thin-film hydration methods. The size and size distribution, polydispersity index (PDI), solid-state properties, entrapment efficiency (EE) and in vitro drug release of liposomes were investigated. The BBR-loaded liposomes prepared by ethanol-injection and thin-film hydration methods presented an average liposome size ranging from 50 nm to 244 nm and from 111 nm to 449 nm, respectively. The PDI values for the liposomes were less than 0.3, suggesting a narrow size distribution. The EE of liposomes ranged from 56% to 92%. Poorly water-soluble BBR was found to accumulate in the bi-layered phospholipid membrane of the liposomes prepared by the thin-film hydration method. The BBR-loaded liposomes generated by both nanofabrication methods presented extended drug release behavior in vitro. In conclusion, both ethanol-injection and thin-film hydration nanofabrication methods are feasible for generating BBR-loaded oral liposomes with a uniform size, high EE and modified drug release behavior in vitro.

In vivo drug release behavior and osseointegration of a doxorubicin-loaded tissue-engineered scaffold

RSC Advances ◽  
2016 ◽  
Vol 6 (80) ◽  
pp. 76237-76245 ◽  
Author(s):  
M. Sun ◽  
M. Chen ◽  
M. Wang ◽  
J. Hansen ◽  
A. Baatrup ◽  
...  
Keyword(s):  
Clinical Study ◽  
Drug Release ◽  
Bone Formation ◽  
Chemotherapeutic Agent ◽  
Dual Function ◽  
Release Behavior ◽  
Drug Release Behavior

This pre-clinical study presented a dual function of a doxorubicin-loaded scaffold for both chemotherapeutic agent delivery and bone formation.

Nano-Surface Modification on Titanium Implants for Drug Delivery

2007 ◽  
Vol 1054 ◽  
Author(s):  
Chang Yao ◽  
Thomas J Webster
Keyword(s):  
Drug Release ◽  
Surface Engineering ◽  
Physical Adsorption ◽  
Titanium Implants ◽  
Orthopedic Implant ◽  
Release Behavior ◽  
Oh Groups ◽  
Chemically Modified ◽  
Drug Release Behavior

ABSTRACTThe surface layer of titanium implants, i.e. titanium dioxide, is responsible for the inertness of titanium-based implants within the human body. However, their cytocompatibility properties and long-term efficacy are limited without further surface engineering since the average functional lifetime of an orthopedic implant is only 10 to 15 years. In this study, an electrochemical method known as anodization was used to create titania nanotubular structures on titanium implant surfaces. These nanotubes were about 60 nm wide (inner diameter) and 200 nm deep. In vitro studies found that anodized surfaces consisting of titania nanotube arrays were favored by bone-forming cells (osteoblasts) compared to unanodized surfaces. These titania nano-tubular structures were utilized here as novel drug release delivery systems. It is proposed that the system designed here can have multi-functional drug release to inhibit infection and wound inflammation while increasing new bone formation. For this purpose, antibiotic drugs (penicillin and streptomycin) were loaded into these nanotubular structures by physical adsorption. To mediate interactions between drug molecules and nanotube walls, anodized titanium nanotubes were modified by silanization to possess amine or methyl groups on their surface instead of −OH groups. Results showed increased hydrophobicity of chemically modified titania nanotubes (methyl > amine > hydroxyl terminated surface). These drug loaded substrates were soaked in phosphate buffered solution in a simulated body environment to determine drug release behavior. Buffer solutions were collected and replaced every day. The eluted drug amounts were measured spectroscopically. Results showed more antibiotic penicillin and streptomycin released from chemically modified nanotubes compared to unanodized titanium substrates; specifically, titania anodized nanotubes functionalized with −OH groups did quite well. In this manner, this study advances titanium currently used in orthopedics to possess drug release behavior which can improve orthopedic implant efficacy.

scholarly journals Drug release behavior of polymeric matrix filled in capsule

2016 ◽  
Vol 24 (6) ◽  
pp. 627-634 ◽  
Author(s):  
Thawatchai Phaechamud ◽  
Wanwilai Darunkaisorn
Keyword(s):  
Drug Release ◽  
Polymeric Matrix ◽  
Release Behavior ◽  
Drug Release Behavior
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