scholarly journals Investigation of Zr(iv) and 89Zr(iv) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging

2013 ◽  
Vol 49 (10) ◽  
pp. 1002-1004 ◽  
Author(s):  
François Guérard ◽  
Yong-Sok Lee ◽  
Raphaël Tripier ◽  
Lawrence P. Szajek ◽  
Jeffrey R. Deschamps ◽  
...  
Keyword(s):  
Quantum Chemistry ◽  
Pet Imaging ◽  
Nuclear Imaging ◽  
Desferrioxamine B

Crystallography, quantum chemistry and potentiometry of Zr(iv) hydroxamate complexes: a combination of tools to improve the development of 89Zr chelation for nuclear imaging.

scholarly journals Tripodal tris(hydroxypyridinone) ligands for immunoconjugate PET imaging with 89Zr4+: comparison with desferrioxamine-B

2015 ◽  
Vol 44 (11) ◽  
pp. 4884-4900 ◽  
Author(s):  
Michelle T. Ma ◽  
Levente K. Meszaros ◽  
Brett M. Paterson ◽  
David J. Berry ◽  
Maggie S. Cooper ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Ambient Conditions ◽  
Desferrioxamine B

A tris(hydroxypyridinone) chelator coordinates the PET imaging isotope, 89Zr4+, rapidly and quantitatively under ambient conditions, but a 89Zr-labelled tris(hydroxypyridinone)-immunoconjugate is not stable to in vivo demetallation.

scholarly journals Reply to the ‘Comment on “Investigation of Zr(iv) and 89Zr(iv) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging”’ by A. Bianchi and M. Savastano, Chem. Commun., 2020, 56, D0CC01189D

2020 ◽  
Vol 56 (83) ◽  
pp. 12667-12668
Author(s):  
François Guérard ◽  
Yong-Sok Lee ◽  
Raphaël Tripier ◽  
Lawrence P. Szajek ◽  
Jeffrey R. Deschamps ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Data Interpretation ◽  
Simplified Models ◽  
Desferrioxamine B ◽  
Potentiometric Data

The relevance of simplified models used for potentiometric data interpretation is discussed in the context of radiolabelling chemistry (herein the complexation of a radiometal, 89Zr, by a ligand L).

scholarly journals The utilization of positron emission tomography in the evaluation of renal health and disease

2021 ◽  
Author(s):  
Kwame Anokye Amoabeng ◽  
Sanna Laurila ◽  
Luis Eduardo Juárez-Orozco ◽  
Anne Beate Langeland Marthinsen ◽  
Dariusz Moczulski ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Pet Imaging ◽  
Nuclear Imaging ◽  
Fatty Acid Uptake ◽  
Renal Perfusion ◽  
Emission Tomography ◽  
Cochrane Library ◽  
Acid Uptake ◽  
Renal Metabolism ◽  
Positron Emission

Abstract Purpose Positron emission tomography (PET) is a nuclear imaging technique that uses radiotracers to visualize metabolic processes of interest across different organs, to diagnose and manage diseases, and monitor therapeutic response. This systematic review aimed to characterize the value of PET for the assessment of renal metabolism and function in subjects with non-oncological metabolic disorders. Methods This review was conducted and reported in accordance with the PRISMA statement. Research articles reporting “kidney” or “renal” metabolism evaluated with PET imaging between 1980 and 2021 were systematically searched in Medline/PubMed, Science Direct, and the Cochrane Library. Search results were exported and stored in RefWorks, the duplicates were removed, and eligible studies were identified, evaluated, and summarized. Results Thirty reports met the inclusion criteria. The majority of the studies were prospective (73.33%, n = 22) in nature. The most utilized PET radiotracers were 15O-labeled radio water (H215O, n = 14) and 18F-fluorodeoxyglucose (18F-FDG, n = 8). Other radiotracers used in at least one study were 14(R,S)-(18)F-fluoro-6-thia-heptadecanoic acid (18F-FTHA), 18F-Sodium Fluoride (18F-NaF), 11C-acetate, 68-Gallium (68Ga), 13N-ammonia (13N-NH3), Rubidium-82 (82Rb), radiolabeled cationic ferritin (RadioCF), 11C‐para-aminobenzoic acid (11C-PABA), Gallium-68 pentixafor (68Ga-Pentixafor), 2-deoxy-2-F-fluoro-d-sorbitol (F-FDS) and 55Co-ethylene diamine tetra acetic acid (55Co-EDTA). Conclusion PET imaging provides an effective modality for evaluating a range of metabolic functions including glucose and fatty acid uptake, oxygen consumption and renal perfusion. Multiple positron emitting radiolabeled racers can be used for renal imaging in clinical settings. PET imaging thus holds the potential to improve the diagnosis of renal disorders, and to monitor disease progression and treatment response.

scholarly journals Investigation of the complexation of natZr(iv) and 89Zr(iv) by hydroxypyridinones for the development of chelators for PET imaging applications

2017 ◽  
Vol 46 (14) ◽  
pp. 4749-4758 ◽  
Author(s):  
F. Guérard ◽  
M. Beyler ◽  
Y.-S. Lee ◽  
R. Tripier ◽  
J.-F. Gestin ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Simple Form ◽  
Nuclear Imaging ◽  
Important Data

Hydroxypyridinones were studied in their most simple form for the complexation of Zr(iv) which provides important data for the design of pre-organized chelators of this metal for nuclear imaging applications.

scholarly journals Comment on “Investigation of Zr(iv) and 89Zr(iv) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging” by F. Guérard, Y.-S. Lee, R. Tripier, L. P. Szajek, J. R. Deschamps and M. W. Brechbiel, Chem. Commun., 2013, 49, 1002

2020 ◽  
Vol 56 (83) ◽  
pp. 12664-12666 ◽  
Author(s):  
Antonio Bianchi ◽  
Matteo Savastano
Keyword(s):  
Pet Imaging ◽  
Desferrioxamine B

Our results show that Zr(iv) has no special properties in the formation of hydroxamate complexes and confirm that it is able to bind up to four hydroxamate groups in solution, although with a normal decreasing ability in the successive steps.

Alterations in regional decreased cerebral blood flow in patients with irritable bowel syndrome-A PET imaging study

2001 ◽  
Vol 120 (5) ◽  
pp. A637-A637
Author(s):  
Y RINGEL ◽  
D DROSSMAN ◽  
T TURKINGTON ◽  
B BRADSHAW ◽  
R COLEMAN ◽  
...  
Keyword(s):  
Blood Flow ◽  
Irritable Bowel Syndrome ◽  
Cerebral Blood Flow ◽  
Pet Imaging ◽  
Imaging Study ◽  
Irritable Bowel

174 Myocardial perfusion by intravenous echo contrast and by nuclear imaging

1999 ◽  
Vol 1 ◽  
pp. S31-S31
Author(s):  
M MORALES ◽  
D ROVAI ◽  
A GIMELLI ◽  
C MARINI ◽  
U STARTARI ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Nuclear Imaging

PET imaging of 5-HT1A receptors in late-life depression: Relationship to treatment response

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S323-S323
Author(s):  
Carolyn C Meltzer ◽  
Julie C Price ◽  
Scott K Ziolko ◽  
Chester A Mathis ◽  
Lisa A Weissfeld ◽  
...  
Keyword(s):  
Treatment Response ◽  
Pet Imaging ◽  
Late Life ◽  
Late Life Depression
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