scholarly journals Investigation of the complexation of natZr(iv) and 89Zr(iv) by hydroxypyridinones for the development of chelators for PET imaging applications

2017 ◽  
Vol 46 (14) ◽  
pp. 4749-4758 ◽  
Author(s):  
F. Guérard ◽  
M. Beyler ◽  
Y.-S. Lee ◽  
R. Tripier ◽  
J.-F. Gestin ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Simple Form ◽  
Nuclear Imaging ◽  
Important Data

Hydroxypyridinones were studied in their most simple form for the complexation of Zr(iv) which provides important data for the design of pre-organized chelators of this metal for nuclear imaging applications.

scholarly journals Investigation of Zr(iv) and 89Zr(iv) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging

2013 ◽  
Vol 49 (10) ◽  
pp. 1002-1004 ◽  
Author(s):  
François Guérard ◽  
Yong-Sok Lee ◽  
Raphaël Tripier ◽  
Lawrence P. Szajek ◽  
Jeffrey R. Deschamps ◽  
...  
Keyword(s):  
Quantum Chemistry ◽  
Pet Imaging ◽  
Nuclear Imaging ◽  
Desferrioxamine B

Crystallography, quantum chemistry and potentiometry of Zr(iv) hydroxamate complexes: a combination of tools to improve the development of 89Zr chelation for nuclear imaging.

scholarly journals The utilization of positron emission tomography in the evaluation of renal health and disease

2021 ◽  
Author(s):  
Kwame Anokye Amoabeng ◽  
Sanna Laurila ◽  
Luis Eduardo Juárez-Orozco ◽  
Anne Beate Langeland Marthinsen ◽  
Dariusz Moczulski ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Pet Imaging ◽  
Nuclear Imaging ◽  
Fatty Acid Uptake ◽  
Renal Perfusion ◽  
Emission Tomography ◽  
Cochrane Library ◽  
Acid Uptake ◽  
Renal Metabolism ◽  
Positron Emission

Abstract Purpose Positron emission tomography (PET) is a nuclear imaging technique that uses radiotracers to visualize metabolic processes of interest across different organs, to diagnose and manage diseases, and monitor therapeutic response. This systematic review aimed to characterize the value of PET for the assessment of renal metabolism and function in subjects with non-oncological metabolic disorders. Methods This review was conducted and reported in accordance with the PRISMA statement. Research articles reporting “kidney” or “renal” metabolism evaluated with PET imaging between 1980 and 2021 were systematically searched in Medline/PubMed, Science Direct, and the Cochrane Library. Search results were exported and stored in RefWorks, the duplicates were removed, and eligible studies were identified, evaluated, and summarized. Results Thirty reports met the inclusion criteria. The majority of the studies were prospective (73.33%, n = 22) in nature. The most utilized PET radiotracers were 15O-labeled radio water (H215O, n = 14) and 18F-fluorodeoxyglucose (18F-FDG, n = 8). Other radiotracers used in at least one study were 14(R,S)-(18)F-fluoro-6-thia-heptadecanoic acid (18F-FTHA), 18F-Sodium Fluoride (18F-NaF), 11C-acetate, 68-Gallium (68Ga), 13N-ammonia (13N-NH3), Rubidium-82 (82Rb), radiolabeled cationic ferritin (RadioCF), 11C‐para-aminobenzoic acid (11C-PABA), Gallium-68 pentixafor (68Ga-Pentixafor), 2-deoxy-2-F-fluoro-d-sorbitol (F-FDS) and 55Co-ethylene diamine tetra acetic acid (55Co-EDTA). Conclusion PET imaging provides an effective modality for evaluating a range of metabolic functions including glucose and fatty acid uptake, oxygen consumption and renal perfusion. Multiple positron emitting radiolabeled racers can be used for renal imaging in clinical settings. PET imaging thus holds the potential to improve the diagnosis of renal disorders, and to monitor disease progression and treatment response.

Background Fitting in the Low-Loss Region of Electron Energy Loss Spectra

1990 ◽  
Vol 48 (2) ◽  
pp. 56-57
Author(s):  
C P Scott ◽  
A J Craven ◽  
C J Gilmore ◽  
A W Bowen
Keyword(s):  
Energy Loss ◽  
Multiple Scattering ◽  
Simple Form ◽  
Single Scattering ◽  
Low Loss ◽  
Characteristic Energy ◽  
Normal Method ◽  
Fitting In ◽  
Electron Energy Loss ◽  
Electron Energy Loss Spectra

The normal method of background subtraction in quantitative EELS analysis involves fitting an expression of the form I=AE-r to an energy window preceding the edge of interest; E is energy loss, A and r are fitting parameters. The calculated fit is then extrapolated under the edge, allowing the required signal to be extracted. In the case where the characteristic energy loss is small (E < 100eV), the background does not approximate to this simple form. One cause of this is multiple scattering. Even if the effects of multiple scattering are removed by deconvolution, it is not clear that the background from the recovered single scattering distribution follows this simple form, and, in any case, deconvolution can introduce artefacts.The above difficulties are particularly severe in the case of Al-Li alloys, where the Li K edge at ~52eV overlaps the Al L2,3 edge at ~72eV, and sharp plasmon peaks occur at intervals of ~15eV in the low loss region. An alternative background fitting technique, based on the work of Zanchi et al, has been tested on spectra taken from pure Al films, with a view to extending the analysis to Al-Li alloys.

Alterations in regional decreased cerebral blood flow in patients with irritable bowel syndrome-A PET imaging study

2001 ◽  
Vol 120 (5) ◽  
pp. A637-A637
Author(s):  
Y RINGEL ◽  
D DROSSMAN ◽  
T TURKINGTON ◽  
B BRADSHAW ◽  
R COLEMAN ◽  
...  
Keyword(s):  
Blood Flow ◽  
Irritable Bowel Syndrome ◽  
Cerebral Blood Flow ◽  
Pet Imaging ◽  
Imaging Study ◽  
Irritable Bowel

174 Myocardial perfusion by intravenous echo contrast and by nuclear imaging

1999 ◽  
Vol 1 ◽  
pp. S31-S31
Author(s):  
M MORALES ◽  
D ROVAI ◽  
A GIMELLI ◽  
C MARINI ◽  
U STARTARI ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Nuclear Imaging

PET imaging of 5-HT1A receptors in late-life depression: Relationship to treatment response

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S323-S323
Author(s):  
Carolyn C Meltzer ◽  
Julie C Price ◽  
Scott K Ziolko ◽  
Chester A Mathis ◽  
Lisa A Weissfeld ◽  
...  
Keyword(s):  
Treatment Response ◽  
Pet Imaging ◽  
Late Life ◽  
Late Life Depression
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