scholarly journals Comment on “Investigation of Zr(iv) and 89Zr(iv) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging” by F. Guérard, Y.-S. Lee, R. Tripier, L. P. Szajek, J. R. Deschamps and M. W. Brechbiel, Chem. Commun., 2013, 49, 1002

2020 ◽  
Vol 56 (83) ◽  
pp. 12664-12666 ◽  
Author(s):  
Antonio Bianchi ◽  
Matteo Savastano

Our results show that Zr(iv) has no special properties in the formation of hydroxamate complexes and confirm that it is able to bind up to four hydroxamate groups in solution, although with a normal decreasing ability in the successive steps.

2015 ◽  
Vol 44 (11) ◽  
pp. 4884-4900 ◽  
Author(s):  
Michelle T. Ma ◽  
Levente K. Meszaros ◽  
Brett M. Paterson ◽  
David J. Berry ◽  
Maggie S. Cooper ◽  
...  

A tris(hydroxypyridinone) chelator coordinates the PET imaging isotope, 89Zr4+, rapidly and quantitatively under ambient conditions, but a 89Zr-labelled tris(hydroxypyridinone)-immunoconjugate is not stable to in vivo demetallation.


2020 ◽  
Vol 56 (83) ◽  
pp. 12667-12668
Author(s):  
François Guérard ◽  
Yong-Sok Lee ◽  
Raphaël Tripier ◽  
Lawrence P. Szajek ◽  
Jeffrey R. Deschamps ◽  
...  

The relevance of simplified models used for potentiometric data interpretation is discussed in the context of radiolabelling chemistry (herein the complexation of a radiometal, 89Zr, by a ligand L).


2013 ◽  
Vol 49 (10) ◽  
pp. 1002-1004 ◽  
Author(s):  
François Guérard ◽  
Yong-Sok Lee ◽  
Raphaël Tripier ◽  
Lawrence P. Szajek ◽  
Jeffrey R. Deschamps ◽  
...  

Crystallography, quantum chemistry and potentiometry of Zr(iv) hydroxamate complexes: a combination of tools to improve the development of 89Zr chelation for nuclear imaging.


2001 ◽  
Vol 120 (5) ◽  
pp. A637-A637
Author(s):  
Y RINGEL ◽  
D DROSSMAN ◽  
T TURKINGTON ◽  
B BRADSHAW ◽  
R COLEMAN ◽  
...  

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S323-S323
Author(s):  
Carolyn C Meltzer ◽  
Julie C Price ◽  
Scott K Ziolko ◽  
Chester A Mathis ◽  
Lisa A Weissfeld ◽  
...  

2011 ◽  
Vol 50 (04) ◽  
pp. N39-N39 ◽  
Author(s):  
H. W. E. Prechtel ◽  
F. A. Verburg ◽  
K. J. Dautzenberg ◽  
F. M. Mottaghy ◽  
F. F. Behrendt ◽  
...  
Keyword(s):  

2005 ◽  
Vol 44 (S 01) ◽  
pp. S51-S57 ◽  
Author(s):  
T. Beyer ◽  
G. Brix

Summary:Clinical studies demonstrate a gain in diagnostic accuracy by employing combined PET/CT instead of separate CT and PET imaging. However, whole-body PET/CT examinations result in a comparatively high radiation burden to patients and thus require a proper justification and optimization to avoid repeated exposure or over-exposure of patients. This review article summarizes relevant data concerning radiation exposure of patients resulting from the different components of a combined PET/CT examination and presents different imaging strategies that can help to balance the diagnostic needs and the radiation protection requirements. In addition various dose reduction measures are discussed, some of which can be adopted from CT practice, while others mandate modifications to the existing hardand software of PET/CT systems.


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