A chromo- and fluorogenic sensor for probing the cancer biomarker lysophosphatidic acid

The Analyst ◽  
2012 ◽  
Vol 137 (8) ◽  
pp. 1853 ◽  
Author(s):  
Wenwen Zhao ◽  
Weimin Liu ◽  
Wenjun Zhang ◽  
Lintao Zeng ◽  
Zhiyuan Fan ◽  
...  
Keyword(s):  
Lysophosphatidic Acid ◽  
Cancer Biomarker

scholarly journals Surface Adsorption of the Cancer Biomarker Lysophosphatidic Acid in Serum Studied by Acoustic Wave Biosensor

Materials ◽  
2021 ◽  
Vol 14 (15) ◽  
pp. 4158
Author(s):  
Brian De La Franier ◽  
Michael Thompson
Keyword(s):  
Acoustic Wave ◽  
Lysophosphatidic Acid ◽  
Electrode Surface ◽  
Biological Fluids ◽  
Thiol Group ◽  
Cancer Biomarker ◽  
Specific Adsorption ◽  
Shear Mode ◽  
Serum Samples ◽  
Fouling Reduction

The thickness shear mode acoustic wave device is of interest for the sensing of biomarkers for diseases in various biological fluids, but suffers from the issue of non-specific adsorption of compounds other than those of interest to the electrode surface, thus affecting the device’s output. The aim of this present study was to determine the level of non-specific adsorption on gold electrodes from serum samples with added ovarian cancer biomarker lysophosphatidic acid in the presence of a surface anti-fouling layer. The latter was an oligoethylene molecule with thiol group for attachment to the electrode surface. It was found that the anti-fouling layer had a minimal effect on the level of both adsorption of components from serum and the marker. This result stands in sharp contrast to the analogous monolayer employed for anti-fouling reduction on silica.

scholarly journals Ultrasensitive and specific fluorescence detection of a cancer biomarkerviananomolar binding to a guanidinium-modified calixarene

2018 ◽  
Vol 9 (8) ◽  
pp. 2087-2091 ◽  
Author(s):  
Zhe Zheng ◽  
Wen-Chao Geng ◽  
Jie Gao ◽  
Yu-Ying Wang ◽  
Hongwei Sun ◽  
...  
Keyword(s):  
Fluorescence Detection ◽  
Lysophosphatidic Acid ◽  
Potential Application ◽  
Cancer Biomarker ◽  
Gynecologic Cancers ◽  
Specific Fluorescence

A well-designed macrocycle affords nanomolar binding to a cancer biomarker lysophosphatidic acid, showing potential application in the diagnosis of gynecologic cancers.

Expression and function of lysophosphatidic acid in theca cells of the bovine ovarian follicle

2014 ◽  
Author(s):  
Emilia Sinderewicz ◽  
Dorota Boruszewska ◽  
Ilona Kowalczyk-Zieba ◽  
Joanna Staszkiewicz ◽  
Katarzyna Grycmacher ◽  
...  
Keyword(s):  
Lysophosphatidic Acid ◽  
Ovarian Follicle ◽  
Theca Cells ◽  
And Function
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