Expression and function of lysophosphatidic acid in theca cells of the bovine ovarian follicle

2014 ◽  
Author(s):  
Emilia Sinderewicz ◽  
Dorota Boruszewska ◽  
Ilona Kowalczyk-Zieba ◽  
Joanna Staszkiewicz ◽  
Katarzyna Grycmacher ◽  
...  
Keyword(s):  
Lysophosphatidic Acid ◽  
Ovarian Follicle ◽  
Theca Cells ◽  
And Function

Expression and function of lysophosphatidic acid in granulosa cells of the bovine ovarian follicle

2014 ◽  
Author(s):  
Izabela Woclawek-Potocka ◽  
Emilia Sinderewicz ◽  
Dorota Boruszewska ◽  
Ilona Kowalczyk-Zieba ◽  
Joanna Staszkiewicz ◽  
...  
Keyword(s):  
Lysophosphatidic Acid ◽  
Granulosa Cells ◽  
Ovarian Follicle ◽  
And Function

Lysophosphatidic acid expression in theca cells depends on the type of bovine ovarian follicle

2016 ◽  
Vol 52 (1) ◽  
pp. 28-34 ◽  
Author(s):  
E Sinderewicz ◽  
K Grycmacher ◽  
D Boruszewska ◽  
I Kowalczyk-Zięba ◽  
I Woclawek-Potocka
Keyword(s):  
Lysophosphatidic Acid ◽  
Ovarian Follicle ◽  
Theca Cells

scholarly journals Lysophosphatidic Acid Signaling in Diabetic Nephropathy

2019 ◽  
Vol 20 (11) ◽  
pp. 2850 ◽  
Author(s):  
Jong Lee ◽  
Donghee Kim ◽  
Yoon Oh ◽  
Hee-Sook Jun
Keyword(s):  
Diabetic Nephropathy ◽  
Signaling Pathways ◽  
Lysophosphatidic Acid ◽  
Kidney Diseases ◽  
Cell Damage ◽  
Cell Structure ◽  
Research Findings ◽  
Stage Renal Disease ◽  
End Stage ◽  
And Function

Lysophosphatidic acid (LPA) is a bioactive phospholipid present in most tissues and body fluids. LPA acts through specific LPA receptors (LPAR1 to LPAR6) coupled with G protein. LPA binds to receptors and activates multiple cellular signaling pathways, subsequently exerting various biological functions, such as cell proliferation, migration, and apoptosis. LPA also induces cell damage through complex overlapping pathways, including the generation of reactive oxygen species, inflammatory cytokines, and fibrosis. Several reports indicate that the LPA–LPAR axis plays an important role in various diseases, including kidney disease, lung fibrosis, and cancer. Diabetic nephropathy (DN) is one of the most common diabetic complications and the main risk factor for chronic kidney diseases, which mostly progress to end-stage renal disease. There is also growing evidence indicating that the LPA–LPAR axis also plays an important role in inducing pathological alterations of cell structure and function in the kidneys. In this review, we will discuss key mediators or signaling pathways activated by LPA and summarize recent research findings associated with DN.

scholarly journals Theca: the forgotten cell of the ovarian follicle

Reproduction ◽  
2010 ◽  
Vol 140 (4) ◽  
pp. 489-504 ◽  
Author(s):  
J M Young ◽  
A S McNeilly
Keyword(s):  
Granulosa Cells ◽  
Developmental Stages ◽  
Vascular System ◽  
Ovarian Follicle ◽  
Primary Follicle ◽  
Diverse Range ◽  
Theca Cells ◽  
Structural Support ◽  
Highly Active ◽  
Thecal Cells

Theca cells function in a diverse range of necessary roles during folliculogenesis; to synthesize androgens, provide crosstalk with granulosa cells and oocytes during development, and provide structural support of the growing follicle as it progresses through the developmental stages to produce a mature and fertilizable oocyte. Thecal cells are thought to be recruited from surrounding stromal tissue by factors secreted from an activated primary follicle. The precise origin and identity of these recruiting factors are currently not clear, but it appears that thecal recruitment and/or differentiation involves not just one signal, but a complex and tightly controlled combination of multiple factors. It is clear that thecal cells are fundamental for follicular growth, providing all the androgens required by the developing follicle(s) for conversion into estrogens by the granulosa cells. Their function is enabled through the establishment of a vascular system providing communication with the pituitary axis throughout the reproductive cycle, and delivering essential nutrients to these highly active cells. During development, the majority of follicles undergo atresia, and the theca cells are often the final follicular cell type to die. For those follicles that do ovulate, the theca cells then undergo hormone-dependent differentiation into luteinized thecal cells of the corpus luteum. While the theca is an essential component of follicle development and ovulation, we do not yet fully understand the control of recruitment and function of theca cells, an important consideration since their function appears to be altered in certain causes of infertility.

STUDIES ON THE GROWTH IN TISSUE CULTURE OF THE CORPUS LUTEUM AND OF THE ISOLATED OVARIAN FOLLICLE OF THE RAT

1961 ◽  
Vol 38 (4) ◽  
pp. 598-610 ◽  
Author(s):  
Stig Kullander
Keyword(s):  
Tissue Culture ◽  
Corpus Luteum ◽  
Steroid Hormones ◽  
Ovarian Follicle ◽  
Ovarian Follicles ◽  
Good Growth ◽  
Hormonal Influence ◽  
Theca Cells ◽  
Ovarian Cells

ABSTRACT The growth of corpus luteum tissue fragments and single ovarian follicles from rat and the hormonal influence on such growth was studied in tissue culture. Both types of tissue gave good growth. Oestrone inhibited the growth of the theca cells around the follicles during dioestrus, but stimulated the growth of the corpus luteum fragments, provided, however, that they had been dissected from rats in dioestrus. Progesterone appeared to inhibit the growth of theca cells from follicles removed from animals in oestrus. F. S. H. inhibited the growth of theca cells from follicles excised from animals in dioestrus, but stimulated the growth of these cells from animals in oestrus. L. T. H. stimulated growth of corpus luteum fragments that had been isolated from animals in oestrus, but had no effect when the specimens had been removed from animals in dioestrus. The findings suggest that steroid hormones and gonadotrophins may directly inhibit or stimulate the growth of certain ovarian cells and that oestrogens are necessary for the gonadotrophic hormones to exert a stimulating effect locally on the ovary.

Formation of Estradiol by Granulosa and Theca Cells of the Equine Ovarian Follicle

Endocrinology ◽  
1965 ◽  
Vol 76 (1) ◽  
pp. 108-114 ◽  
Author(s):  
KENNETH J. RYAN ◽  
ROGER V. SHORT
Keyword(s):  
Ovarian Follicle ◽  
Theca Cells

MP48-04 EXPRESSION AND FUNCTION OF LYSOPHOSPHATIDIC ACID RECEPTOR 1 IN BLADDER CANCER

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
masao kataoka ◽  
tomoyuki koguchi ◽  
Michihiro Yabe ◽  
Yuuichi Satoh ◽  
Nobuhiro Haga ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Lysophosphatidic Acid ◽  
Acid Receptor ◽  
Lysophosphatidic Acid Receptor ◽  
And Function

scholarly journals Foxl2, a Forkhead Transcription Factor, Modulates Nonclassical Activity of the Estrogen Receptor-α

Endocrinology ◽  
2009 ◽  
Vol 150 (11) ◽  
pp. 5085-5093 ◽  
Author(s):  
So-Youn Kim ◽  
Jeffrey Weiss ◽  
Minghan Tong ◽  
Monica M. Laronda ◽  
Eun-Jig Lee ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Transcription Factor ◽  
Direct Action ◽  
Ovarian Follicle ◽  
Estrogen Receptor Α ◽  
Ovary Development ◽  
Activator Protein 1 ◽  
Forkhead Transcription Factor ◽  
Protein Levels ◽  
And Function

Foxl2 is a forkhead transcription factor required for ovary development and ovarian follicle maturation. In this report, we identified and characterized a functional relationship between Foxl2 expression and estrogen receptor (ER)-α signaling. We show that Foxl2 has no effect on classical ERα-mediated transcription, which occurs through canonical estrogen response elements. However, Foxl2 suppresses ERα signaling through nonclassical tethered transcriptional pathways. Specifically, the selective ER modulator tamoxifen stimulates activator protein-1 (AP1)-dependent transcription via the ERα, and this enhancement is blocked by Foxl2. Two lines of evidence suggest that Foxl2 suppression is mediated by physical interactions with ERα rather than direct action at AP1 binding sites. First, ERα is coimmunoprecipitated with Foxl2. Second, activation of a upstream activating sequence (UAS) reporter by Gal4-cJun in the presence of ERα and tamoxifen was blocked by Foxl2, demonstrating suppression in the absence of an AP1 site. Cyclooxygenase-2 (COX2), which is required for ovulation, was identified through expression profiling as a candidate physiological target for nonclassical ERα signaling and thus modulation by ERα/Foxl2 interactions. This possibility was confirmed by two sets of experiments. COX2 protein levels were induced by ERα in the presence of tamoxifen, and protein expression was suppressed by Foxl2. In addition, ERα stimulation of the COX2 promoter was repressed by Foxl2. We conclude that ERα and Foxl2 interact and that Foxl2 selectively suppresses ERα-mediated transcription of AP1-regulated genes. These data provide a potential point of convergence for ERα and Foxl2 to regulate ovarian development and function.

scholarly journals Effects of bovine somatotrophin (bST) on ovarian function in post-partum beef cows

1996 ◽  
Vol 8 (6) ◽  
pp. 951 ◽  
Author(s):  
LP Andrade ◽  
SM Rhind ◽  
IA Wright ◽  
SR McMillen ◽  
PJ Goddard ◽  
...  
Keyword(s):  
Ovarian Function ◽  
Post Partum ◽  
Ovarian Follicle ◽  
Beef Cows ◽  
Ovarian Follicle Development ◽  
Factor I ◽  
Glucose Injection ◽  
Igf I ◽  
And Function ◽  
Bovine Somatotrophin

The effects of bovine somatotrophin (bST) on ovarian follicle development and function and associated gonadotrophin profiles during the first nine weeks post partum were investigated in beef cows. Thirty-two cows (Shorthorn x Galloway) in moderately low body condition (BC) at calving were fed to maintain BC thereafter. At Weeks 2, 4, 6 and 8 post partum, animals were injected with 320 mg bovine somatotrophin (bST) (T, treated; n = 17) or with the carrier oil only (C, control; n = 15). Ovulation occurred in 4 of 17 T cows and 0 of 15 C cows (P = 0.10) by nine week post partum. Treatment with bST did not affect the numbers of small (3-8 mm in diameter) or large (> 8 mm in diameter) follicles or the granulosa cell populations but enhanced the oestradiol (P < 0.05) and insulin-like growth factor-I (IGF-I) content (P < 0.01) of large follicles by nine weeks post partum. It did not significantly affect the testosterone concentrations of large follicles. Circulating concentrations of growth hormone (GH) and IGF-I were higher in T cows than in C cows (P < 0.001) but were unrelated to gonadotrophin profiles or gonadotrophin receptor concentrations in the follicles. At Week 8, plasma insulin concentrations were higher in T cows than in C cows both before (P < 0.05) and after (P < 0.05) glucose injection. It is concluded that GH may play an important role in mediating the effects of nutritional state on ovarian function during the post-partum period, possibly through alteration of intrafollicular IGF-I concentrations.

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