Self-assembled micelles prepared from poly(ɛ-caprolactone)-poly(ethylene glycol) and poly(ɛ-caprolactone/glycolide)-poly(ethylene glycol) block copolymers for sustained drug delivery

2017 ◽  
Vol 135 (9) ◽  
pp. 45732 ◽  
Author(s):  
Xiangke Sun ◽  
Xue Liu ◽  
Chenglong Li ◽  
Yuandou Wang ◽  
Li Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Sustained Drug Delivery ◽  
Self Assembled ◽  
Poly Ethylene

A block copolymer of zwitterionic polyphosphoester and polylactic acid for drug delivery

2015 ◽  
Vol 3 (7) ◽  
pp. 1105-1113 ◽  
Author(s):  
Rong Sun ◽  
Xiao-Jiao Du ◽  
Chun-Yang Sun ◽  
Song Shen ◽  
Yang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Block Copolymers ◽  
Ethylene Glycol ◽  
Polylactic Acid ◽  
Anticancer Drug ◽  
Poly Ethylene Glycol ◽  
Anticancer Drug Delivery ◽  
Poly Ethylene

Zwitterionic polyphosphoester containing polymers are synthesized and evaluated as an alternative to poly(ethylene glycol) block copolymers for anticancer drug delivery.

Self-Assembled Nanoparticles of Ribozymes with Poly(ethylene glycol)-b-Poly(L-lysine) Block Copolymers

2006 ◽  
Vol 45 (1B) ◽  
pp. 591-595 ◽  
Author(s):  
Jae Hyun Jeong ◽  
Yong Woo Cho ◽  
Bokyung Jung ◽  
Kinam Park ◽  
Jong-Duk Kim
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Self Assembled ◽  
Poly Ethylene

Fabrication of Mixed Polymeric Micelles Based on Stimuli-Responsive Amphiphilic Copolymers for Drug Delivery and Controlled Release

NANO ◽  
2020 ◽  
Vol 15 (03) ◽  
pp. 2050040 ◽  
Author(s):  
Jia Liu ◽  
Juan Li ◽  
Tingting Liu
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Block Copolymers ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Polymeric Micelles ◽  
Poly Ethylene Glycol ◽  
Mixed Polymeric Micelles ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

In this report, mixed polymeric micelles (MPMs) system self-assembled from two kinds of cholesterol-grafted amphiphilic block copolymers cholesterol modified poly ([Formula: see text]-amino esters)-grafted disulfide poly (ethylene glycol) methyl ether (PAE(-ss-mPEG)-[Formula: see text]-Chol) and poly([Formula: see text]-amino ester)-g-poly(ethylene glycol) methyl ether-cholesterol (PAE-[Formula: see text]-mPEG-Chol) were prepared for drug delivery and controlled release with pH and redox-responsibilities. The self-assembly of two block copolymers was evaluated by measurement of critical micelle concentration (CMC) values using fluorescence spectroscopy. The hydrodynamic diameter, polydispersity index (PDI) and zeta-potential of MPMs in aqueous were recorded by dynamic light scattering (DLS) at different conditions. Doxorubicin (DOX) was efficiently encapsulated in the micellar core by the hydrophobic interaction. The drug loading content (LC) and encapsulation efficacy (EE) of MPMs with different formulations were evaluated. The DOX was released due to the swelling and disassembly of MPMs induced by low pH and high glutathione (GSH) concentrations. The in vitro results demonstrated that drug release rate and cumulative release were obviously dependent on pH values and reducing agents. The results showed that the MPMs could be the potential anticancer drug delivery carriers with pH/redox-triggered drug release profile.

Self-Assembled Methoxy Poly(Ethylene Glycol)-Cholesterol Micelles for Hydrophobic Drug Delivery

2013 ◽  
Vol 102 (3) ◽  
pp. 1054-1062 ◽  
Author(s):  
Yiyi Yu ◽  
Yingju He ◽  
Bei Xu ◽  
Zhiyao He ◽  
Ying Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Hydrophobic Drug ◽  
Poly Ethylene Glycol ◽  
Self Assembled ◽  
Poly Ethylene
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