Folate receptor targeted, carboxymethyl chitosan functionalized iron oxide nanoparticles: a novel ultradispersed nanoconjugates for bimodal imaging

Nanoscale ◽  
2011 ◽  
Vol 3 (4) ◽  
pp. 1653 ◽  
Author(s):  
Dipsikha Bhattacharya ◽  
Manasmita Das ◽  
Debashis Mishra ◽  
Indranil Banerjee ◽  
Sumanta K. Sahu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Folate Receptor ◽  
Carboxymethyl Chitosan ◽  
Oxide Nanoparticles ◽  
Bimodal Imaging

scholarly journals One pot synthesis of amine-functionalized and angular-shaped superparamagnetic iron oxide nanoparticles for MR/fluorescence bimodal imaging application

RSC Advances ◽  
2017 ◽  
Vol 7 (21) ◽  
pp. 12876-12885 ◽  
Author(s):  
Donggeon Yoo ◽  
Chaedong Lee ◽  
Bokyung Seo ◽  
Yuanzhe Piao
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
One Pot ◽  
Water Dispersible ◽  
Bimodal Imaging ◽  
Amine Functionalized ◽  
Simple Preparation ◽  
Imaging Application

Herein, we report the simple preparation of water dispersible angular-shaped amine-functionalized super-paramagnetic iron oxide nanoparticles (A-SPIONs).

scholarly journals Engineered superparamagnetic iron oxide nanoparticles (SPIONs) for dual-modality imaging of intracranial glioblastoma via EGFRvIII targeting

2019 ◽  
Vol 10 ◽  
pp. 1860-1872 ◽  
Author(s):  
Xianping Liu ◽  
Chengjuan Du ◽  
Haichun Li ◽  
Ting Jiang ◽  
Zimiao Luo ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Optical Imaging ◽  
Iron Oxide Nanoparticles ◽  
Tumor Targeting ◽  
Tumor Resection ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Bimodal Imaging

In this work, a peptide-modified, biodegradable, nontoxic, brain-tumor-targeting nanoprobe based on superparamagnetic iron oxide nanoparticles (SPIONs) (which have been commonly used as T 2-weighted magnetic resonance (MR) contrast agents) was successfully synthesized and applied for accurate molecular MR imaging and sensitive optical imaging. PEPHC1, a short peptide which can specifically bind to epidermal growth factor receptor variant III (EGFRvIII) that is overexpressed in glioblastoma, was conjugated with SPIONs to construct the nanoprobe. Both in vitro and in vivo MR and optical imaging demonstrated that the as-constructed nanoprobe was effective and sensitive for tumor targeting with desirable biosafety. Given its desirable properties such as a 100 nm diameter (capable of penetration of the blood–brain barrier) and bimodal imaging capability, this novel and versatile multimodal nanoprobe could bring a new perspective for elucidating intracranial glioblastoma preoperative diagnosis and the accuracy of tumor resection.

Sign in / Sign up

Export Citation Format

Share Document