Surface-initiated DNA self-assembly as an enzyme-free and nanoparticle-free strategy towards signal amplification of an electrochemical DNA sensor

The Analyst ◽  
2011 ◽  
Vol 136 (3) ◽  
pp. 459-462 ◽  
Author(s):  
Yuanqin Zheng ◽  
Yulin Li ◽  
Na Lu ◽  
Zhaoxiang Deng
Keyword(s):  
Self Assembly ◽  
Signal Amplification ◽  
Dna Sensor ◽  
Electrochemical Dna Sensor

Electrochemical DNA sensor for specific detection of picomolar Hg(ii) based on exonuclease III-assisted recycling signal amplification

The Analyst ◽  
2015 ◽  
Vol 140 (6) ◽  
pp. 2029-2036 ◽  
Author(s):  
Xiaorong Gan ◽  
Huimin Zhao ◽  
Shuo Chen ◽  
Xie Quan
Keyword(s):  
Coordination Chemistry ◽  
Signal Amplification ◽  
Quantitative Detection ◽  
Dna Sensor ◽  
Specific Detection ◽  
Exonuclease Iii ◽  
Electrochemical Dna Sensor

An ultrasensitive methodology was successfully developed for the quantitative detection of picomolar Hg2+ based on the combination of thymine–Hg2+–thymine (T–Hg2+–T) coordination chemistry and exonuclease III-aided recycling signal amplification.

A highly sensitive DNA sensor for attomolar detection of the BRCA1 gene: signal amplification with gold nanoparticle clusters

The Analyst ◽  
2015 ◽  
Vol 140 (8) ◽  
pp. 2713-2718 ◽  
Author(s):  
P. Abdul Rasheed ◽  
N. Sandhyarani
Keyword(s):  
Gold Nanoparticle ◽  
Signal Amplification ◽  
Brca1 Gene ◽  
Dna Sensor ◽  
Electrochemical Dna Sensor ◽  
Highly Sensitive ◽  
Nanoparticle Clusters

Gold nanoparticle clusters were successfully implemented signal amplification in an electrochemical DNA sensor.

Silver Nanoparticles Decorated Polyaniline Nanowires-Based Electrochemical DNA Sensor: Two-step Electrochemical Synthesis

2020 ◽  
Vol 167 (8) ◽  
pp. 087508 ◽  
Author(s):  
Luyen Thi Tran ◽  
Hoang Vinh Tran ◽  
Hue Thi Minh Dang ◽  
Chinh Dang Huynh ◽  
Tuan Anh Mai
Keyword(s):  
Silver Nanoparticles ◽  
Electrochemical Synthesis ◽  
Dna Sensor ◽  
Electrochemical Dna Sensor ◽  
Polyaniline Nanowires

scholarly journals Electrochemical DNA Sensor Based on Carbon Black—Poly(Neutral Red) Composite for Detection of Oxidative DNA Damage

Sensors ◽  
2018 ◽  
Vol 18 (10) ◽  
pp. 3489 ◽  
Author(s):  
Yurii Kuzin ◽  
Dominika Kappo ◽  
Anna Porfireva ◽  
Dmitry Shurpik ◽  
Ivan Stoikov ◽  
...  
Keyword(s):  
Carbon Black ◽  
Oxidative Dna Damage ◽  
Electrochemical Impedance ◽  
Neutral Red ◽  
Redox Activity ◽  
Antitumor Drugs ◽  
Oxygen Species ◽  
Dna Sensor ◽  
Electrochemical Dna Sensor ◽  
Polymeric Dye

Voltammetric DNA sensor has been proposed on the platform of glassy carbon electrode covered with carbon black with adsorbed pillar[5]arene molecules. Electropolymerization of Neutral Red performed in the presence of native or oxidatively damaged DNA resulted in formation of hybrid material which activity depended on the DNA conditions. The assembling of the surface layer was confirmed by scanning electron microscopy and electrochemical impedance spectroscopy. The influence of DNA and pillar[5]arene on redox activity of polymeric dye was investigated and a significant increase of the peak currents was found for DNA damaged by reactive oxygen species generated by Cu2+/H2O2 mixture. Pillar[5]arene improves the electron exchange conditions and increases the response and its reproducibility. The applicability of the DNA sensor developed was shown on the example of ascorbic acid as antioxidant. It decreases the current in the concentration range from 1.0 μM to 1.0 mM. The possibility to detect antioxidant activity was qualitatively confirmed by testing tera infusion. The DNA sensor developed can find application in testing of carcinogenic species and searching for new antitumor drugs.

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