scholarly journals An efficient synthesis of (±)-frondosin B using a Stille–Heck reaction sequence

2010 ◽  
Vol 8 (6) ◽  
pp. 1290 ◽  
Author(s):  
Kye-Simeon Masters ◽  
Bernard L. Flynn
Keyword(s):  
Heck Reaction ◽  
Efficient Synthesis ◽  
Reaction Sequence ◽  
Frondosin B

Efficient synthesis of 2,3-dimethoxy-5-methyl-6-morpholinomethyl-1,4-benzoquinone hydrochloride

2015 ◽  
Vol 70 (4) ◽  
pp. 221-223 ◽  
Author(s):  
Jin Wang ◽  
Teng-huo-sheng Liao ◽  
Jian Yang
Keyword(s):  
Title Compound ◽  
Good Yield ◽  
Efficient Synthesis ◽  
Reaction Sequence

AbstractThe title compound (5) was prepared by a reaction sequence starting from 2,3,4,5-tetramethoxytoluene (1) via the Blanc reaction, oxidation and alkylation. The described method provides a good yield of the C-6 heterocyclic-substituted benzoquinone derivative and is suitable for the synthesis of other benzoquinone derivatives.

scholarly journals A new and efficient protocol for the synthesis of the key intermediate of Palbociclib

2019 ◽  
Vol 43 (1-2) ◽  
pp. 14-19
Author(s):  
Shuting Li ◽  
Wanfeng Yang ◽  
Min Ji ◽  
Jin Cai ◽  
Junqing Chen
Keyword(s):  
Nucleophilic Substitution ◽  
Heck Reaction ◽  
Ring Closure ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Synthetic Strategy

A new and efficient synthesis of 6-bromo-8-cyclopentyl-5-methyl-2-(methylsulfinyl)-pyrido[2,3-d]pyrimidin-7(8H)-one, a key intermediate of Palbociclib, starting from thiouracil was described. This protocol involved methylation, nucleophilic substitution, bromination, nucleophilic substitution, Heck reaction, ring closure, oxidation, and bromination to afford a key intermediate of Palbociclib with approximately 35% overall yield. The advantages of this developed synthetic strategy included improved overall yield, inexpensive starting materials, and readily controllable and cleaner reaction conditions.

Novel Carbonyl Bromoallylation/Heck Reaction Sequence. Stereocontrolled Access to Bicyclic β-Lactams

2005 ◽  
Vol 70 (7) ◽  
pp. 2713-2719 ◽  
Author(s):  
Benito Alcaide ◽  
Pedro Almendros ◽  
Raquel Rodríguez-Acebes
Keyword(s):  
Heck Reaction ◽  
Reaction Sequence

ChemInform Abstract: Concise Synthesis of Highly Substituted Benzo[a]quinolizines by a Multicomponent Reaction/Allylation/Heck Reaction Sequence.

ChemInform ◽  
2012 ◽  
Vol 43 (22) ◽  
pp. no-no
Author(s):  
Rene den Heeten ◽  
Leon J. P. van der Boon ◽  
Daniel L. J. Broere ◽  
Elwin Janssen ◽  
Frans J. J. de Kanter ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Heck Reaction ◽  
Reaction Sequence
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