ChemInform Abstract: Concise Synthesis of Highly Substituted Benzo[a]quinolizines by a Multicomponent Reaction/Allylation/Heck Reaction Sequence.

ChemInform ◽  
2012 ◽  
Vol 43 (22) ◽  
pp. no-no
Author(s):  
Rene den Heeten ◽  
Leon J. P. van der Boon ◽  
Daniel L. J. Broere ◽  
Elwin Janssen ◽  
Frans J. J. de Kanter ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Heck Reaction ◽  
Reaction Sequence

Concise Synthesis of Highly Substituted Benzo[a]quinolizines by a Multicomponent Reaction/Allylation/Heck Reaction Sequence

2011 ◽  
Vol 2012 (2) ◽  
pp. 275-280 ◽  
Author(s):  
René den Heeten ◽  
Léon J. P. van der Boon ◽  
Daniël L. J. Broere ◽  
Elwin Janssen ◽  
Frans J. J. de Kanter ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Heck Reaction ◽  
Reaction Sequence

scholarly journals Concise Synthesis of Highly Substituted Benzo[a]quinolizines by a Multicomponent Reaction/Allylation/Heck Reaction Sequence (Eur. J. Org. Chem. 2/2012)

2011 ◽  
Vol 2012 (2) ◽  
pp. n/a-n/a
Author(s):  
René den Heeten ◽  
Léon J. P. van der Boon ◽  
Daniël L. J. Broere ◽  
Elwin Janssen ◽  
Frans J. J. de Kanter ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Heck Reaction ◽  
Reaction Sequence

scholarly journals Concise Synthesis of Macrocycles by Multicomponent Reactions

Synthesis ◽  
2018 ◽  
Vol 50 (05) ◽  
pp. 1027-1038 ◽  
Author(s):  
Alexander Dömling ◽  
Eman Abdelraheem ◽  
Samad Khaksar
Keyword(s):  
Amino Acid ◽  
Multicomponent Reaction ◽  
Ring Opening ◽  
Multicomponent Reactions ◽  
Reaction Pathway ◽  
Ring Closure ◽  
Side Chains ◽  
Reaction Sequence ◽  
Cyclic Anhydride

A short reaction pathway was devised to synthesize a library of artificial 18–27-membered macrocycles. The five-step reaction sequence involves ring opening of a cyclic anhydride with a diamine, esterification, coupling with an amino acid isocyanide, saponification, and, finally, macro-ring closure using an Ugi or, alternatively, a Passerini multicomponent reaction. Three out of the five steps allow for the versatile introduction of linker elements, side chains, and substituents with aromatic, heteroaromatic, and aliphatic character. The versatile pathway is described for 15 different target macrocycles on a mmol scale. Artificial macrocycles have recently become of great interest due to their potential to bind to difficult post-genomic targets.

Novel Carbonyl Bromoallylation/Heck Reaction Sequence. Stereocontrolled Access to Bicyclic β-Lactams

2005 ◽  
Vol 70 (7) ◽  
pp. 2713-2719 ◽  
Author(s):  
Benito Alcaide ◽  
Pedro Almendros ◽  
Raquel Rodríguez-Acebes
Keyword(s):  
Heck Reaction ◽  
Reaction Sequence

Distillable ionic liquids for a new multicomponent reaction

2007 ◽  
Vol 79 (11) ◽  
pp. 1869-1877 ◽  
Author(s):  
Anthony E. Rosamilia ◽  
Christopher R. Strauss ◽  
Janet L. Scott
Keyword(s):  
Carbon Dioxide ◽  
Ionic Liquid ◽  
Ionic Liquids ◽  
Multicomponent Reaction ◽  
Reaction Medium ◽  
Building Blocks ◽  
Substituted Anilines ◽  
Reaction Sequence ◽  
Unsaturated Ketones ◽  
Direct Preparation

Adducts of dimethylamine and carbon dioxide form a "distillable ionic liquid" (DIMCARB) that may used as both a reaction medium and catalyst in the direct, atom-economical synthesis of useful synthetic building blocks, such as mono-condensed α,β-unsaturated ketones. The utilization of such building blocks in the synthesis of two new classes of versatile macrocycles, by a sequence of condensation reactions (H2O by-product), is described. Investigation into the mechanism of action of DIMCARB catalysis and observation of an aniline impurity arising from a competing reaction sequence led to development of a new multicomponent reaction for the direct preparation of 2- or 4-substituted anilines. Some of the macrocycles and anilines are, respectively, supramolecular host compounds and ligands for the preparation of metal complexes.

scholarly journals Novel Carbonyl Bromoallylation/Heck Reaction Sequence. Stereocontrolled Access to Bicyclic β-Lactams.

ChemInform ◽  
2005 ◽  
Vol 36 (34) ◽  
Author(s):  
Benito Alcaide ◽  
Pedro Almendros ◽  
Raquel Rodriguez-Acebes
Keyword(s):  
Heck Reaction ◽  
Reaction Sequence

A three-component approach to isoquinoline derivatives by cycloaddition/Heck reaction sequence

2007 ◽  
Vol 48 (24) ◽  
pp. 4255-4258 ◽  
Author(s):  
Masato Oikawa ◽  
Yoshiyuki Takeda ◽  
Shinya Naito ◽  
Daisuke Hashizume ◽  
Hiroyuki Koshino ◽  
...  
Keyword(s):  
Heck Reaction ◽  
Reaction Sequence ◽  
Component Approach ◽  
Isoquinoline Derivatives

Synthesis of alkyloxy stilbenes by one-pot O-alkylation-Wittig and O-alkylation-Wittig–Heck reaction sequence

2013 ◽  
Vol 54 (1) ◽  
pp. 80-84 ◽  
Author(s):  
Krupa N. Patel ◽  
Bola V. Kamath ◽  
Ashutosh V. Bedekar
Keyword(s):  
Heck Reaction ◽  
Reaction Sequence ◽  
One Pot

Annulation of internal alkynes through a hydroamination/aza-Heck reaction sequence for the regioselective synthesis of indoles

Tetrahedron ◽  
2008 ◽  
Vol 64 (5) ◽  
pp. 769-777 ◽  
Author(s):  
Lutz Ackermann ◽  
René Sandmann ◽  
Amparo Villar ◽  
Ludwig T. Kaspar
Keyword(s):  
Heck Reaction ◽  
Regioselective Synthesis ◽  
Reaction Sequence ◽  
Internal Alkynes
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