ChemInform Abstract: An Efficient Synthesis of 4-Arylquinolin-2(1H)-ones and 3-Alkenyl-4-arylquinolin-2(1H)-one Using a Pd/NiFe2O4-Catalyzed Consecutive Heck Reaction.

ChemInform ◽  
2012 ◽  
Vol 43 (17) ◽  
pp. no-no
Author(s):  
Sanjay R. Borhade ◽  
Suresh B. Waghmode
Keyword(s):  
Heck Reaction ◽  
Efficient Synthesis

scholarly journals A new and efficient protocol for the synthesis of the key intermediate of Palbociclib

2019 ◽  
Vol 43 (1-2) ◽  
pp. 14-19
Author(s):  
Shuting Li ◽  
Wanfeng Yang ◽  
Min Ji ◽  
Jin Cai ◽  
Junqing Chen
Keyword(s):  
Nucleophilic Substitution ◽  
Heck Reaction ◽  
Ring Closure ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Synthetic Strategy

A new and efficient synthesis of 6-bromo-8-cyclopentyl-5-methyl-2-(methylsulfinyl)-pyrido[2,3-d]pyrimidin-7(8H)-one, a key intermediate of Palbociclib, starting from thiouracil was described. This protocol involved methylation, nucleophilic substitution, bromination, nucleophilic substitution, Heck reaction, ring closure, oxidation, and bromination to afford a key intermediate of Palbociclib with approximately 35% overall yield. The advantages of this developed synthetic strategy included improved overall yield, inexpensive starting materials, and readily controllable and cleaner reaction conditions.

Efficient Synthesis of an Enantiopure Thiasteroid by a Double Heck Reaction

2004 ◽  
Vol 57 (7) ◽  
pp. 635 ◽  
Author(s):  
Lutz F. Tietze ◽  
Lars P. Lücke ◽  
Felix Major ◽  
Peter Müller
Keyword(s):  
Heck Reaction ◽  
Efficient Synthesis ◽  
Heck Reactions ◽  
Thiophene Derivatives ◽  
Intramolecular Heck Reaction

The thiaestrane 7 was synthesized by two sequential Heck reactions starting from the thiophene derivatives 8a–8c, which contain a (Z)-halogenovinyl group, and the enantiopure hydrindene 2a. The first intermolecular Pd-catalyzed reaction leads to 11a and 11b in a highly regio- and diastereoselective manner. A subsequent intramolecular Heck reaction catalyzed by the palladacycle 4 then gave the thiasteroid 7 with an unusual cis-junction of the rings B and C.

Efficient Synthesis of Pyridylacrylonitriles via the Heck Reaction

2006 ◽  
Vol 36 (17) ◽  
pp. 2525-2532 ◽  
Author(s):  
Kui Mei ◽  
Junbo Wang ◽  
Xianming Hu
Keyword(s):  
Heck Reaction ◽  
Efficient Synthesis
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