Cyclodextrin–dextran based in situ hydrogel formation: a carrier for hydrophobic drugs

Soft Matter ◽  
2010 ◽  
Vol 6 (1) ◽  
pp. 85-87 ◽  
Author(s):  
Ke Peng ◽  
Itsuro Tomatsu ◽  
Alexander V. Korobko ◽  
Alexander Kros
Keyword(s):  
Hydrophobic Drugs ◽  
Hydrogel Formation ◽  
In Situ Hydrogel

PEG–PLLA and PEG–PDLA multiblock copolymers: Synthesis and in situ hydrogel formation by stereocomplexation

2006 ◽  
Vol 116 (2) ◽  
pp. e17-e19 ◽  
Author(s):  
C. Hiemstra ◽  
Z.Y. Zhong ◽  
X. Jiang ◽  
W.E. Hennink ◽  
P.J. Dijkstra ◽  
...  
Keyword(s):  
Multiblock Copolymers ◽  
Hydrogel Formation ◽  
In Situ Hydrogel

scholarly journals Improved method for synthesis of cysteine modified hyaluronic acid for in situ hydrogel formation

2015 ◽  
Vol 51 (47) ◽  
pp. 9662-9665 ◽  
Author(s):  
Xin Zhang ◽  
Pengcheng Sun ◽  
Lingzi Huangshan ◽  
Bi-Huang Hu ◽  
Phillip B. Messersmith
Keyword(s):  
Hyaluronic Acid ◽  
Chemical Modification ◽  
Hydroxyl Groups ◽  
Improved Method ◽  
Ether Bond ◽  
Hydrogel Formation ◽  
New Strategy ◽  
In Situ Hydrogel ◽  
Acid Conjugate

We developed a new strategy for the functionalization of hyaluronic acid by chemical modification of its C-6 hydroxyl groups through an ether bond to obtain a cysteine–hyaluronic acid conjugate.

scholarly journals Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 567
Author(s):  
Ivona Tomić ◽  
Sandra Miočić ◽  
Ivan Pepić ◽  
Dubravka Šimić ◽  
Jelena Filipović-Grčić
Keyword(s):  
Azelaic Acid ◽  
Controlled Trial ◽  
Acne Vulgaris ◽  
Topical Therapy ◽  
Adverse Event Rate ◽  
Double Blind ◽  
Inflammatory Lesions ◽  
First Choice ◽  
In Situ Hydrogel

Acne vulgaris is a common, multifactorial, inflammatory skin disease affecting the pilosebaceous unit. Topical therapy is the first choice in the treatment of mild to moderate acne, and azelaic acid (AZA) is one of the most commonly used drugs. The aim of this study was to evaluate the safety and efficacy of a low-dose azelaic acid nanocrystal (AZA-NC) hydrogel in the treatment of mild to moderate facial acne. The study was designed as a double-blind, randomized controlled trial. Patients were randomized to treatment with AZA-NC hydrogel, 10%, or AZA cream, 20%, administered in quantities of approximately 1 g twice daily for 8 weeks. Efficacy of therapy was measured by the number of lesions and safety by the frequency and severity of adverse events. At week 8, the success rate of treatment with AZA-NC hydrogel, 10%, was 36.51% (p < 0.001) versus 30.37% (p < 0.001) with AZA cream. At week 8, treatment with AZA-NC hydrogel, 10%, resulted in a significant reduction in total inflammatory lesions from baseline of 39.15% (p < 0.001) versus 33.76% (p < 0.001) with AZA cream, and a reduction in non-inflammatory lesions from baseline of 34.58% (p < 0.001) versus 27.96% (p < 0.001) with AZA cream, respectively. The adverse event rate was low and mostly mild.

Thermosensitive in situ hydrogel based on the hybrid of hyaluronic acid and modified PCL/PEG triblock copolymer

2014 ◽  
Vol 108 ◽  
pp. 26-33 ◽  
Author(s):  
Zesheng Lv ◽  
Longlong Chang ◽  
Xingwen Long ◽  
Jianping Liu ◽  
Yuzhang Xiang ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Triblock Copolymer ◽  
In Situ Hydrogel

scholarly journals The interaction between self – assembling peptides and emodin and the controlled release of emodin from in-situ hydrogel

2019 ◽  
Vol 47 (1) ◽  
pp. 3961-3975 ◽  
Author(s):  
Weipeng Wei ◽  
Cui Meng ◽  
Yuhe Wang ◽  
Yongsheng Huang ◽  
Wenbin Du ◽  
...  
Keyword(s):  
Controlled Release ◽  
Self Assembling ◽  
In Situ Hydrogel

Droplet-Templated Antisolvent Spherical Crystallization of Hydrophilic and Hydrophobic Drugs with an in situ Formed Binder

2017 ◽  
Vol 7 (3) ◽  
pp. 1700797 ◽  
Author(s):  
Tonghan Gu ◽  
Eunice W. Q. Yeap ◽  
Zheng Cao ◽  
Denise Z. L. Ng ◽  
Yinying Ren ◽  
...  
Keyword(s):  
Hydrophobic Drugs ◽  
Spherical Crystallization

scholarly journals Fabrication of Injectable, Porous Hyaluronic Acid Hydrogel Based on an In-Situ Bubble-Forming Hydrogel Entrapment Process

Polymers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1138
Author(s):  
Lixuan Wang ◽  
Shiyan Dong ◽  
Yutong Liu ◽  
Yifan Ma ◽  
Jingjing Zhang ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Regenerative Medicine ◽  
In Vivo Studies ◽  
Injectable Hydrogels ◽  
Cell Behaviors ◽  
Porous Architecture ◽  
In Situ Hydrogel

Injectable hydrogels have been widely applied in the field of regenerative medicine. However, current techniques for injectable hydrogels are facing a challenge when trying to generate a biomimetic, porous architecture that is well-acknowledged to facilitate cell behaviors. In this study, an injectable, interconnected, porous hyaluronic acid (HA) hydrogel based on an in-situ bubble self-generation and entrapment process was developed. Through an amide reaction between HA and cystamine dihydrochloride activated by EDC/NHS, CO2 bubbles were generated and were subsequently entrapped inside the substrate due to a rapid gelation-induced retention effect. HA hydrogels with different molecular weights and concentrations were prepared and the effects of the hydrogel precursor solution’s concentration and viscosity on the properties of hydrogels were investigated. The results showed that HA10-10 (10 wt.%, MW 100,000 Da) and HA20-2.5 (2.5 wt.%, MW 200,000 Da) exhibited desirable gelation and obvious porous structure. Moreover, HA10-10 represented a high elastic modulus (32 kPa). According to the further in vitro and in vivo studies, all the hydrogels prepared in this study show favorable biocompatibility for desirable cell behaviors and mild host response. Overall, such an in-situ hydrogel with a self-forming bubble and entrapment strategy is believed to provide a robust and versatile platform to engineer injectable hydrogels for a variety of applications in tissue engineering, regenerative medicine, and personalized therapeutics.

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