In situ hydrogel formation for biomedical applications using acoustic cavitation from high intensity focused ultrasound

2018 ◽  
Vol 143 (3) ◽  
pp. 1928-1928
Author(s):  
Umesh Jonnalagadda ◽  
Feifei Li ◽  
Jim Lee ◽  
Atsushi Goto ◽  
Minh Nguyen ◽  
...  
Keyword(s):  
High Intensity ◽  
Biomedical Applications ◽  
Focused Ultrasound ◽  
Acoustic Cavitation ◽  
High Intensity Focused Ultrasound ◽  
Hydrogel Formation ◽  
In Situ Hydrogel

scholarly journals Nanoparticle-Mediated Acoustic Cavitation Enables High Intensity Focused Ultrasound Ablation Without Tissue Heating

2018 ◽  
Vol 10 (43) ◽  
pp. 36786-36795 ◽  
Author(s):  
Adem Yildirim ◽  
Dennis Shi ◽  
Shambojit Roy ◽  
Nicholas T. Blum ◽  
Rajarshi Chattaraj ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Acoustic Cavitation ◽  
High Intensity Focused Ultrasound ◽  
Tissue Heating ◽  
Ultrasound Ablation ◽  
Focused Ultrasound Ablation

Treatment of uterine fibroid tumors in an in situ rat model using high-intensity focused ultrasound

2003 ◽  
Vol 80 ◽  
pp. 761-767 ◽  
Author(s):  
Amid Keshavarzi ◽  
Shahram Vaezy ◽  
Misty L Noble ◽  
Marla K Paun ◽  
Victor Y Fujimoto
Keyword(s):  
Uterine Fibroid ◽  
Rat Model ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound

scholarly journals Effects of Sub-Atmospheric Pressure and Dissolved Oxygen Concentration on Lesions Generated in Ex Vivo Tissues by High Intensity Focused Ultrasound

2020 ◽  
Author(s):  
Min He ◽  
Zhiqiang Zhong ◽  
Deping Zeng ◽  
Xiaobo Gong ◽  
Zhibiao Wang ◽  
...  
Keyword(s):  
Dissolved Oxygen ◽  
Oxygen Concentration ◽  
Atmospheric Pressure ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Ambient Pressure ◽  
Acoustic Cavitation ◽  
High Intensity Focused Ultrasound ◽  
Dissolved Oxygen Concentration ◽  
Significant Difference

Abstract BackgroundAcoustic cavitation plays an important role in the medical treatment using high intensity focused ultrasound (HIFU), but unnecessarily strong cavitation also could deform the morphology and enlarge the size of lesions. It is known that the increase of ambient hydrostatic pressure (Pstat) can control the acoustic cavitation but the question how decrease of Pstat and dissolved oxygen concentration (DOC) influences the strength of cavitation has not been thoroughly answered.MethodsEx vivo bovine liver tissues were immersed in degassed water with different DOC of 1.0 mg/L, 1.5 mg/L and 2.0 mg/L. Ultrasound (US) of 1 MHz and the spatial and temporal average intensity (Isata) of 6500 W/cm2 was used to expose two groups of in vitro bovine livers for two seconds; one group was under atmospheric pressure (Pstat = 1 bar) and the other was under sub-atmospheric pressure (Pstat = 0.1 bar). Acoustic cavitation was detected by a passive cavitation detector (PCD) during the exposure process. Echo signals at the focal zone of HIFU were monitored by B-mode ultrasound imaging before and after exposure.ResultsThe results demonstrated a significant difference of broadband acoustic emissions from the cavitation bubbles, echo signals on B mode image, morphology of lesions under various condition of ambient pressure and DOC. The lesion volume in tissue was increased with the increase of ambient pressure and DOC.ConclusionCavitation could be suppressed through sub-atmospheric pressure and low DOC level in liver tissue, which could provide a method of controlling cavitation in HIFU treatment to avoid unpredictable lesions.

scholarly journals Effects of sub-atmospheric pressure and dissolved oxygen concentration on lesions generated in ex vivo tissues by high intensity focused ultrasound

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Min He ◽  
Zhiqiang Zhong ◽  
Deping Zeng ◽  
Xiaobo Gong ◽  
Zhibiao Wang ◽  
...  
Keyword(s):  
Dissolved Oxygen ◽  
Atmospheric Pressure ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Ex Vivo ◽  
Ambient Pressure ◽  
Acoustic Cavitation ◽  
High Intensity Focused Ultrasound ◽  
Dissolved Oxygen Concentration ◽  
The Difference

Abstract Background Acoustic cavitation plays an important role in the medical treatment using high-intensity focused ultrasound (HIFU), but unnecessarily strong cavitation also could deform the morphology and enlarge the size of lesions. It is known that the increase of ambient hydrostatic pressure (Pstat) can control the acoustic cavitation. But the question of how the decrease of Pstat and dissolved oxygen concentration (DOC) influence the strength of cavitation has not been thoroughly answered. In this study, we aimed to investigate the relationship among the Pstat, DOC and the strength of cavitation. Methods Ex vivo bovine liver tissues were immersed in degassed water with different DOC of 1.0 mg/L, 1.5 mg/L and 2.0 mg/L. Ultrasound (US) of 1 MHz and the spatial and temporal average intensity (Isata) of 6500 W/cm2 was used to expose two groups of in vitro bovine livers for 2 s; one group was under atmospheric pressure (Pstat = 1 bar) and the other was under sub-atmospheric pressure (Pstat = 0.1 bar). Acoustic cavitation was detected by a passive cavitation detector (PCD) during the exposure process. Echo signals at the focal zone of HIFU were monitored by B-mode ultrasound imaging before and after exposure. The difference between two pressure groups was tested using paired sample t-test. The difference among different DOC groups was evaluated by one-way analysis of variance (ANOVA). Results The results demonstrated a significant difference of broadband acoustic emissions from the cavitation bubbles, echo signals on B-mode image, morphology of lesions under various conditions of ambient pressure and DOC. The lesion volume in tissue was increased with the increase of ambient pressure and DOC. Conclusion Cavitation could be suppressed through sub-atmospheric pressure and low DOC level in liver tissue, which could provide a method of controlling cavitation in HIFU treatment to avoid unpredictable lesions.

scholarly journals Quantitative Ultrasound Imaging for Monitoring In Situ High-Intensity Focused Ultrasound Exposure

2014 ◽  
Vol 36 (4) ◽  
pp. 239-255 ◽  
Author(s):  
Goutam Ghoshal ◽  
Jeremy P. Kemmerer ◽  
Chandra Karunakaran ◽  
Rami Abuhabsah ◽  
Rita J. Miller ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
Quantitative Ultrasound ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Exposure
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