Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs

CrystEngComm ◽  
2009 ◽  
Vol 11 (9) ◽  
pp. 1823-1827 ◽  
Author(s):  
Srinivasulu Aitipamula ◽  
Pui Shan Chow ◽  
Reginald B. H. Tan
Keyword(s):  
Solid State ◽  
Stable Form ◽  
Active Pharmaceutical Ingredients ◽  
Gentisic Acid ◽  
Pharmaceutical Cocrystals ◽  
Pharmaceutical Ingredients ◽  
Combination Drugs ◽  
Pharmaceutical Cocrystal

The first example of a trimorphic cocrystal involving two active pharmaceutical ingredients, ethenzamide and gentisic acid, is reported; metastable polymorphs convert to the stable form upon solid-state grinding; pharmaceutical cocrystals involving two or more APIs have potential relevance to combination drugs.

scholarly journals Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid

2016 ◽  
Author(s):  
Yong Du ◽  
Qiang Cai ◽  
Jiadan Xue ◽  
Qi Zhang
Keyword(s):  
Solid State ◽  
Spectroscopic Techniques ◽  
Vibrational Modes ◽  
Active Pharmaceutical Ingredients ◽  
Aminobenzoic Acid ◽  
Parent Materials ◽  
Pharmaceutical Development ◽  
Pharmaceutical Ingredients ◽  
Pharmaceutical Cocrystal ◽  
Rich Information

Cocrystallizaiton could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development. In this study, the cocrystal of nitrofurantoin and 4-aminobenzoic acid was prepared with solid-state (solvent-free or green-chemistry) grinding approach, and the above cocrystal has been characterized by Raman and terahertz vibrational spectroscopic techniques. Spectral results show that the vibrational modes of the cocrystal within the whole spectral region are different from those of the corresponding parent materials. The dynamic process of such pharmaceutical cocrystal formation has also been monitored directly with Raman spectra. These results offer us unique means for characterizing the cocrystal conformation from molecule-level and also provide us rich information about the reaction dynamic of cocrystal formation within pharmaceutical fields.

Reply to the ‘Comment on “Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs” by S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2009, 11, 1823’

CrystEngComm ◽  
2018 ◽  
Vol 20 (3) ◽  
pp. 373-374
Author(s):  
Srinivasulu Aitipamula ◽  
Pui Shan Chow ◽  
Reginald B. H. Tan
Keyword(s):  
Lattice Energy ◽  
Previous Article ◽  
Active Pharmaceutical Ingredients ◽  
Energy Calculations ◽  
Pharmaceutical Ingredients ◽  
Combination Drugs ◽  
Pharmaceutical Cocrystal

The inadvertent errors in the lattice energy calculations of the cocrystal polymorphs reported in our previous article were rectified.

Comment on “Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs” by S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2009, 11, 1823

CrystEngComm ◽  
2018 ◽  
Vol 20 (3) ◽  
pp. 370-372 ◽  
Author(s):  
Łukasz Szeleszczuk ◽  
Dariusz Maciej Pisklak ◽  
Monika Zielińska-Pisklak
Keyword(s):  
Detailed Analysis ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Combination Drugs ◽  
Pharmaceutical Cocrystal ◽  
The Stability

This is a commentary on a paper by S. Aitipamula et al. (CrystEngComm, 2009, 11, 1823–1827) on the detailed analysis of the stability of trimorphic cocrystals.

35Cl solid-state NMR of HCl salts of active pharmaceutical ingredients: structural prediction, spectral fingerprinting and polymorph recognition

CrystEngComm ◽  
2014 ◽  
Vol 16 (31) ◽  
pp. 7334-7356 ◽  
Author(s):  
Marcel Hildebrand ◽  
Hiyam Hamaed ◽  
Andrew M. Namespetra ◽  
John M. Donohue ◽  
Riqiang Fu ◽  
...  
Keyword(s):  
Solid State ◽  
Plane Wave ◽  
Dft Calculations ◽  
First Principles ◽  
Solid State Nmr ◽  
Active Pharmaceutical Ingredients ◽  
Structural Prediction ◽  
Pharmaceutical Ingredients

A series of HCl salts of active pharmaceutical ingredients (APIs) have been characterized via35Cl solid-state NMR (SSNMR) spectroscopy and first-principles plane-wave DFT calculations of 35Cl NMR interaction tensors.

Chemometric approaches to low-content quantification (LCQ) in solid-state mixtures using Raman mapping spectroscopy

2017 ◽  
Vol 9 (44) ◽  
pp. 6293-6301 ◽  
Author(s):  
Boyan Li ◽  
Yannick Casamayou-Boucau ◽  
Amandine Calvet ◽  
Alan G. Ryder
Keyword(s):  
Solid State ◽  
Pharmaceutical Manufacturing ◽  
Active Pharmaceutical Ingredients ◽  
Raman Mapping ◽  
Pharmaceutical Ingredients

The low-content quantification (LCQ) of active pharmaceutical ingredients or impurities in solid mixtures is important in pharmaceutical manufacturing and analysis.

On the relaxation dynamics in active pharmaceutical ingredients: solid-state 1H NMR, quasi-elastic neutron scattering and periodic DFT study of acebutolol hydrochloride

RSC Advances ◽  
2015 ◽  
Vol 5 (71) ◽  
pp. 57502-57514 ◽  
Author(s):  
A. Pajzderska ◽  
K. Drużbicki ◽  
A. Kiwilsza ◽  
M. A. Gonzalez ◽  
M. Jarek ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Solid State ◽  
Dft Calculations ◽  
Neutron Scattering ◽  
Active Pharmaceutical Ingredients ◽  
Relaxation Dynamics ◽  
Elastic Neutron ◽  
Pharmaceutical Ingredients ◽  
Elastic Neutron Scattering ◽  
Periodic Dft

Molecular dynamics of acebutolol hydrochloride was thoroughly explored by combining QENS and NMR experiments with solid-state DFT calculations.

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