scholarly journals Solid‐state characterization of novel active pharmaceutical ingredients: Cocrystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt

2011 ◽  
Vol 100 (8) ◽  
pp. 3268-3283 ◽  
Author(s):  
Krzysztof J. Paluch ◽  
Lidia Tajber ◽  
Curtis J. Elcoate ◽  
Owen I. Corrigan ◽  
Simon E. Lawrence ◽  
...  
Keyword(s):  
Solid State ◽  
Adipic Acid ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Solid State Characterization

Raman and Terahertz Spectroscopic Characterization of Solid-state Cocrystal Formation within Specific Active Pharmaceutical Ingredients

2020 ◽  
Vol 26 (38) ◽  
pp. 4829-4846
Author(s):  
Yong Du ◽  
Jiadan Xue ◽  
Zhi Hong
Keyword(s):  
Solid State ◽  
Drug Research ◽  
Terahertz Spectroscopy ◽  
Spectroscopic Characterization ◽  
Time Dependent ◽  
Active Pharmaceutical Ingredients ◽  
Covalent Bonds ◽  
Pharmaceutical Ingredients ◽  
Kinetic Information

: Cocrystallization of specific active pharmaceutical ingredients (APIs) in the solid-state phase is becoming a feasible way to improve their corresponding physicochemical properties and ultimate bioavailability without making and breaking any covalent bonds within them. Many recent reports deal with the characterization and analysis topics of pharmaceutical APIs-based cocrystals. In this mini-review, we will focus on the recent steady-state and time-dependent spectroscopic investigation into the cocrystallization of specific APIs based on both Raman and emerging terahertz spectroscopy in pharmaceutical fields. Distinctive spectral, structural and also kinetic information of pharmaceutical APIs-based cocrystals are obtained and discussed, which would highlight the potential of vibrational spectroscopy as an attractive technique for various drug research and development during cocrystallization of specific APIs.

Solid-State Characterization of Amorphous and Mesomorphous Calcium Ketoprofen

2010 ◽  
Vol 99 (9) ◽  
pp. 3684-3697 ◽  
Author(s):  
Faraj Atassi ◽  
Chen Mao ◽  
Ahmad S. Masadeh ◽  
Stephen R. Byrn
Keyword(s):  
Solid State ◽  
Solid State Characterization

Microwave assisted synthesis and solid-state characterization of lithocholyl amides of isomeric aminopyridines

Steroids ◽  
2011 ◽  
Vol 76 (3) ◽  
pp. 261-268 ◽  
Author(s):  
Kari V. Ahonen ◽  
Manu K. Lahtinen ◽  
Arto M. Valkonen ◽  
Martin Dračínský ◽  
Erkki T. Kolehmainen
Keyword(s):  
Solid State ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Solid State Characterization

The solid state structure and environmental polarization effect of a novel asymmetric azine

2017 ◽  
Vol 41 (19) ◽  
pp. 11361-11371 ◽  
Author(s):  
Clodoaldo Valverde ◽  
Wesley F. Vaz ◽  
Jean M. F. Custodio ◽  
Vitor S. Duarte ◽  
Paulo S. Carvalho-Jr ◽  
...  
Keyword(s):  
Solid State ◽  
Polarization Effect ◽  
State Structure ◽  
Solid State Structure ◽  
Solid State Characterization

Extensive solid state characterization of a novel asymmetric azine and its environmental polarization effect is reported.

Solid-State Characterization of Paclitaxel

1997 ◽  
Vol 86 (12) ◽  
pp. 1458-1463 ◽  
Author(s):  
Richard T. Liggins ◽  
W.L. Hunter ◽  
Helen M. Burt
Keyword(s):  
Solid State ◽  
Solid State Characterization

scholarly journals Assay and physicochemical characterization of the antiparasitic albendazole

2012 ◽  
Vol 48 (2) ◽  
pp. 281-290 ◽  
Author(s):  
Noely Camila Tavares Cavalcanti ◽  
Giovana Damasceno Sousa ◽  
Maria Alice Maciel Tabosa ◽  
José Lamartine Soares Sobrinho ◽  
Leila Bastos Leal ◽  
...  
Keyword(s):  
Physicochemical Characterization ◽  
Analytical Techniques ◽  
Assay Method ◽  
Active Pharmaceutical Ingredients ◽  
X Ray Diffraction ◽  
Melting Points ◽  
X Ray ◽  
Pharmaceutical Ingredients ◽  
Complementary Techniques

The aim of this study was to characterize three batches of albendazole by pharmacopeial and complementary analytical techniques in order to establish more detailed specifications for the development of pharmaceutical forms. The ABZ01, ABZ02, and ABZ03 batches had melting points of 208 ºC, 208 ºC, and 209 ºC, respectively. X-ray diffraction revealed that all three batches showed crystalline behavior and the absence of polymorphism. Scanning electron microscopy showed that all the samples were crystals of different sizes with a strong tendency to aggregate. The samples were insoluble in water (5.07, 4.27, and 4.52 mg mL-1, respectively) and very slightly soluble in 0.1 M HCl (55.10, 56.90, and 61.70 mg mL-1, respectively) and additionally showed purities within the range specified by the Brazilian Pharmacopoeia 5th edition (F. Bras. V; 98% to 102%). The pharmacopeial assay method was not reproducible and some changes were necessary. The method was validated and showed to be selective, specific, linear, robust, precise, and accurate. From this characterization, we concluded that pharmacopeial techniques alone are not able to detect subtle differences in active pharmaceutical ingredients; therefore, the use of other complementary techniques is required to ensure strict quality control in the pharmaceutical industry.

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