Chemometric approaches to low-content quantification (LCQ) in solid-state mixtures using Raman mapping spectroscopy

2017 ◽  
Vol 9 (44) ◽  
pp. 6293-6301 ◽  
Author(s):  
Boyan Li ◽  
Yannick Casamayou-Boucau ◽  
Amandine Calvet ◽  
Alan G. Ryder
Keyword(s):  
Solid State ◽  
Pharmaceutical Manufacturing ◽  
Active Pharmaceutical Ingredients ◽  
Raman Mapping ◽  
Pharmaceutical Ingredients

The low-content quantification (LCQ) of active pharmaceutical ingredients or impurities in solid mixtures is important in pharmaceutical manufacturing and analysis.

35Cl solid-state NMR of HCl salts of active pharmaceutical ingredients: structural prediction, spectral fingerprinting and polymorph recognition

CrystEngComm ◽  
2014 ◽  
Vol 16 (31) ◽  
pp. 7334-7356 ◽  
Author(s):  
Marcel Hildebrand ◽  
Hiyam Hamaed ◽  
Andrew M. Namespetra ◽  
John M. Donohue ◽  
Riqiang Fu ◽  
...  
Keyword(s):  
Solid State ◽  
Plane Wave ◽  
Dft Calculations ◽  
First Principles ◽  
Solid State Nmr ◽  
Active Pharmaceutical Ingredients ◽  
Structural Prediction ◽  
Pharmaceutical Ingredients

A series of HCl salts of active pharmaceutical ingredients (APIs) have been characterized via35Cl solid-state NMR (SSNMR) spectroscopy and first-principles plane-wave DFT calculations of 35Cl NMR interaction tensors.

scholarly journals Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid

2016 ◽  
Author(s):  
Yong Du ◽  
Qiang Cai ◽  
Jiadan Xue ◽  
Qi Zhang
Keyword(s):  
Solid State ◽  
Spectroscopic Techniques ◽  
Vibrational Modes ◽  
Active Pharmaceutical Ingredients ◽  
Aminobenzoic Acid ◽  
Parent Materials ◽  
Pharmaceutical Development ◽  
Pharmaceutical Ingredients ◽  
Pharmaceutical Cocrystal ◽  
Rich Information

Cocrystallizaiton could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development. In this study, the cocrystal of nitrofurantoin and 4-aminobenzoic acid was prepared with solid-state (solvent-free or green-chemistry) grinding approach, and the above cocrystal has been characterized by Raman and terahertz vibrational spectroscopic techniques. Spectral results show that the vibrational modes of the cocrystal within the whole spectral region are different from those of the corresponding parent materials. The dynamic process of such pharmaceutical cocrystal formation has also been monitored directly with Raman spectra. These results offer us unique means for characterizing the cocrystal conformation from molecule-level and also provide us rich information about the reaction dynamic of cocrystal formation within pharmaceutical fields.

On the relaxation dynamics in active pharmaceutical ingredients: solid-state 1H NMR, quasi-elastic neutron scattering and periodic DFT study of acebutolol hydrochloride

RSC Advances ◽  
2015 ◽  
Vol 5 (71) ◽  
pp. 57502-57514 ◽  
Author(s):  
A. Pajzderska ◽  
K. Drużbicki ◽  
A. Kiwilsza ◽  
M. A. Gonzalez ◽  
M. Jarek ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Solid State ◽  
Dft Calculations ◽  
Neutron Scattering ◽  
Active Pharmaceutical Ingredients ◽  
Relaxation Dynamics ◽  
Elastic Neutron ◽  
Pharmaceutical Ingredients ◽  
Elastic Neutron Scattering ◽  
Periodic Dft

Molecular dynamics of acebutolol hydrochloride was thoroughly explored by combining QENS and NMR experiments with solid-state DFT calculations.

Ionic co-crystals of racetams: solid-state properties enhancement of neutral active pharmaceutical ingredients via addition of Mg2+ and Ca2+ chlorides

CrystEngComm ◽  
2014 ◽  
Vol 16 (26) ◽  
pp. 5887 ◽  
Author(s):  
Fabrizia Grepioni ◽  
Johan Wouters ◽  
Dario Braga ◽  
Saverio Nanna ◽  
Baptiste Fours ◽  
...  
Keyword(s):  
Solid State ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

Raman and Terahertz Spectroscopic Characterization of Solid-state Cocrystal Formation within Specific Active Pharmaceutical Ingredients

2020 ◽  
Vol 26 (38) ◽  
pp. 4829-4846
Author(s):  
Yong Du ◽  
Jiadan Xue ◽  
Zhi Hong
Keyword(s):  
Solid State ◽  
Drug Research ◽  
Terahertz Spectroscopy ◽  
Spectroscopic Characterization ◽  
Time Dependent ◽  
Active Pharmaceutical Ingredients ◽  
Covalent Bonds ◽  
Pharmaceutical Ingredients ◽  
Kinetic Information

: Cocrystallization of specific active pharmaceutical ingredients (APIs) in the solid-state phase is becoming a feasible way to improve their corresponding physicochemical properties and ultimate bioavailability without making and breaking any covalent bonds within them. Many recent reports deal with the characterization and analysis topics of pharmaceutical APIs-based cocrystals. In this mini-review, we will focus on the recent steady-state and time-dependent spectroscopic investigation into the cocrystallization of specific APIs based on both Raman and emerging terahertz spectroscopy in pharmaceutical fields. Distinctive spectral, structural and also kinetic information of pharmaceutical APIs-based cocrystals are obtained and discussed, which would highlight the potential of vibrational spectroscopy as an attractive technique for various drug research and development during cocrystallization of specific APIs.

Radiation sterilization of antibiotics in solid state

2020 ◽  
Vol 16 ◽  
Author(s):  
Karolina Kilińska ◽  
Przemysław Zalewski
Keyword(s):  
High Temperature ◽  
Solid State ◽  
Ionizing Radiation ◽  
Room Temperature ◽  
Promising Method ◽  
Radiation Sterilization ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Increased Temperature ◽  
Temperature And Humidity

: Radiation sterilization is a promising method of obtaining sterile active pharmaceutical ingredients (API), excipients and formulations. One of the best methods of sterilization is to use ionizing radiation. The greatest advantage of ionizing radiation is fact that can be conducted at room temperature or lower. Therefore this procedure of sterilization is reserved for drugs sensitive to the high temperature of autoclaving. Solutions of parenterally administered antibiotics must be absolutely aseptic. Most of the antibiotics are susceptible for the degradation at increased temperature and humidity so radiation is often used to obtain sterile bactericidal drugs.

Sign in / Sign up

Export Citation Format

Share Document