DNA and aptamer stabilized gold nanoparticles for targeted delivery of anticancer therapeutics

Nanoscale ◽  
2014 ◽  
Vol 6 (13) ◽  
pp. 7436-7442 ◽  
Author(s):  
Alfonso Latorre ◽  
Christian Posch ◽  
Yolanda Garcimartín ◽  
Anna Celli ◽  
Martina Sanlorenzo ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Targeted Delivery ◽  
Cancer Therapeutics ◽  
Malignant Cells ◽  
Anti Cancer ◽  
Anticancer Therapeutics

Aptamer modified gold nanoparticles target malignant cells. Anti-cancer therapeutics are released after cleavage of a self-immolative linker by intracellular triggers.

scholarly journals Surface-Initiated Atom Transfer Polymerized Anionic Corona on Gold Nanoparticles for Anti-Cancer Therapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 261
Author(s):  
Wei Mao ◽  
Sol Lee ◽  
Ji Un Shin ◽  
Hyuk Sang Yoo
Keyword(s):  
Gold Nanoparticles ◽  
Transfection Efficiency ◽  
Cancer Therapeutics ◽  
Atom Transfer ◽  
Layer By Layer ◽  
Dependent Manner ◽  
Metallic Particles ◽  
Anti Cancer

Surface initiated atom transfer radical polymerization (SI-ATRP) documented a simple but efficient technique to grow a dense polymer layer on any surface. Gold nanoparticles (AuNPs) give a broad surface to immobilize sulfhyryl group-containing initiators for SI-ATRP; in addition, AuNPs are the major nanoparticulate carriers for delivery of anti-cancer therapeutics, since they are biocompatible and bioinert. In this work, AuNPs with a disulfide initiator were polymerized with sulfoethyl methacrylate by SI-ATRP to decorate the particles with anionic corona, and branched polyethyeleneimine (PEI) and siRNA were sequentially layered onto the anionic corona of AuNP by electrostatic interaction. The in vitro anti-cancer effect confirmed that AuNP with anionic corona showed higher degrees of apoptosis as well as suppression of the oncogene expression in a siRNA dose-dependent manner. The in vivo study of tumor-bearing nude mice revealed that mice treated with c-Myc siRNA-incorporated AuNPs showed dramatically decreased tumor size in comparison to those with free siRNA for 4 weeks. Furthermore, histological examination and gene expression study revealed that the decorated AuNP significantly suppressed c-Myc expression. Thus, we envision that the layer-by-layer assembly on the anionic brushes can be potentially used to incorporate nucleic acids onto metallic particles with high transfection efficiency.

Cyclodextrin-covered gold nanoparticles for targeted delivery of an anti-cancer drug

2009 ◽  
Vol 19 (16) ◽  
pp. 2310 ◽  
Author(s):  
Chiyoung Park ◽  
Hyewon Youn ◽  
Hana Kim ◽  
Taiho Noh ◽  
Yeon Hee Kook ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Targeted Delivery ◽  
Cancer Drug ◽  
Anti Cancer

Gold nanospheres and nanorods for anti-cancer therapy: comparative studies of fabrication, surface-decoration, and anti-cancer treatments

Nanoscale ◽  
2020 ◽  
Vol 12 (28) ◽  
pp. 14996-15020
Author(s):  
Wei Mao ◽  
Young Ju Son ◽  
Hyuk Sang Yoo
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Cancer Therapeutics ◽  
Drug Carriers ◽  
Gold Nanospheres ◽  
Cancer Treatments ◽  
Anti Cancer ◽  
Diagnostic Agents ◽  
Irradiation Therapy ◽  
Surface Decoration

Various gold nanoparticles have been explored as cancer therapeutics because they can be widely engineered for use as efficient drug carriers and diagnostic agents, and in photo-irradiation therapy.

Recent Advances in Gelatin-Based Nanomedicine for Targeted Delivery of Anti-Cancer Drugs

2021 ◽  
Vol 27 ◽  
Author(s):  
Faisal Raza ◽  
Liu Siyu ◽  
Hajra Zafar ◽  
Zul Kamal ◽  
Bo Zheng ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Cancer Therapeutics ◽  
Natural Polymers ◽  
Gelatin Nanoparticles ◽  
Good Surface ◽  
Recent Advances ◽  
Wide Range ◽  
Anti Cancer ◽  
Cancer Nanomedicine

: Nanoparticles based on natural polymers are utilized for the development of a wide range of drug delivery systems (DDS) in the current era. Gelatin-based nanoparticles, for example, are a remarkable cancer therapy with high efficacy and specificity. This paper reviews the recent advancements in gelatin-based nanomedicine for use in cancer therapeutics. Due to the characteristics features of gelatin, such as biocompatibility, biodegradability, stability, and good surface properties, these nanoparticles provide high therapeutic potency in cancer nanomedicine. The surface of gelatin can be modified in a number of ways using various ligands to explore the platform for the development of a more novel DDS. Various methods are available for the preparation of gelatin nanomedicine discussed in this review. In addition, various cross-linkers to stabilized nanocarriers and stimuli base gelatin nanoparticles are reviewed. Furthermore, recent advances and research in gelatin-based nanomedicine are discussed. Also, some drawbacks and challenges are evaluated. In general, this paper paves the pathway to identify the details about the gelatin-based DDS for cancer therapy.

scholarly journals Peptide-functionalized gold nanoparticles: versatile biomaterials for diagnostic and therapeutic applications

2017 ◽  
Vol 5 (5) ◽  
pp. 872-886 ◽  
Author(s):  
Jingyi Zong ◽  
Steven L. Cobb ◽  
Neil R. Cameron
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Targeted Drug Delivery ◽  
Potential Application ◽  
Cancer Therapeutics ◽  
Therapeutic Applications ◽  
Functionalized Gold Nanoparticles ◽  
Anti Cancer ◽  
Targeted Drug ◽  
Oligonucleotide Delivery

This review provides an overview of the current methods used for preparing peptide-functionalized GNPs, and discusses the key properties of this class of biomaterial. In particular, their potential application in areas of sensing, targeted drug delivery, anti-cancer therapeutics and oligonucleotide delivery are discussed.

scholarly journals Targeted Delivery of Exosomes Armed with Anti-Cancer Therapeutics

Membranes ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 85
Author(s):  
Hojun Choi ◽  
Hwayoung Yim ◽  
Cheolhyoung Park ◽  
So-Hee Ahn ◽  
Yura Ahn ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Surface Engineering ◽  
Cancer Therapeutics ◽  
Tumor Burden ◽  
Passive Targeting ◽  
Anti Cancer ◽  
Therapeutic Molecules ◽  
Tumor Parenchyma ◽  
And Control

Among extracellular vesicles, exosomes have gained great attention for their role as therapeutic vehicles for delivering various active pharmaceutical ingredients (APIs). Exosomes “armed” with anti-cancer therapeutics possess great potential for an efficient intracellular delivery of anti-cancer APIs and enhanced targetability to tumor cells. Various technologies are being developed to efficiently incorporate anti-cancer APIs such as genetic materials (miRNA, siRNA, mRNA), chemotherapeutics, and proteins into exosomes and to induce targeted delivery to tumor burden by exosomal surface modification. Exosomes can incorporate the desired therapeutic molecules via direct exogenous methods (e.g., electroporation and sonication) or indirect methods by modifying cells to produce “armed” exosomes. The targeted delivery of “armed” exosomes to tumor burden could be accomplished either by “passive” targeting using the natural tropism of exosomes or by “active” targeting via the surface engineering of exosomal membranes. Although anti-cancer exosome therapeutics demonstrated promising results in preclinical studies, success in clinical trials requires thorough validation in terms of chemistry, manufacturing, and control techniques. While exosomes possess multiple advantages over synthetic nanoparticles, challenges remain in increasing the loading efficiency of anti-cancer agents into exosomes, as well as establishing quantitative and qualitative analytical methods for monitoring the delivery of in vivo administered exosomes and exosome-incorporated anti-cancer agents to the tumor parenchyma.

Gold Nanoparticles- Boon in Cancer Theranostics

2020 ◽  
Vol 26 (40) ◽  
pp. 5134-5151 ◽  
Author(s):  
Mehak Jindal ◽  
Manju Nagpal ◽  
Manjinder Singh ◽  
Geeta Aggarwal ◽  
Gitika Arora Dhingra
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Targeted Delivery ◽  
Early Stage ◽  
Cancer Therapeutics ◽  
Malignant Tumour ◽  
Chemotherapeutic Agents ◽  
Metal Nanoparticle ◽  
Abnormal Growth

Background: Cancer is the world’s second-largest cause of death, with an estimated 9.6 million fatalities in 2018. Malignant tumour (cancer) is caused by a mixture of genetic modifications due to the environmental variables that tend to activate or inactivate different genes, ultimately resulting in neoplastic transformations. Cancer is a multi-stage process that results from the conversion of the ordinary cells to tumour cells and progresses from a pre-cancer lesion to abnormal growth. Methods: Chemotherapy inhibits the ability of the cells to divide rapidly in an abnormal manner, but this treatment simultaneously affects the entire cellular network in the human body leading to cytotoxic effects. In this review article, the same issue has been addressed by discussing various aspects of the newer class of drugs in cancer therapeutics, i.e., Gold Nanoparticles (AuNPs) from metal nanoparticle (NP) class. Results: Metal NPs are advantageous over conventional chemotherapy as the adverse drug reactions are lesser. Additionally, ease of drug delivery, targeting and gene silencing are salient features of this treatment. Functionalized ligand-targeting metal NPs provide better energy deposition control in tumour. AuNPs are promising agents in the field of cancer treatment and are comprehensively studied as contrast agents, carriers of medicinal products, radiosensitizers and photothermal agents. For the targeted delivery of chemotherapeutic agents, AuNPs are used and also tend to enhance tumour imaging in vivo for a variety of cancer types and diseased organs. Conclusion: The first part of the review focuses on various nano-carriers that are used for cancer therapy and deals with the progression of metal NPs in cancer therapy. The second part emphasizes the use of nanotechnology by considering the latest studies for diagnostic and therapeutic properties of AuNPs. AuNPs present the latest studies in the field of nanotechnology, which leads to the development of early-stage clinical trials. The next part of the review discusses the major features of five principal types of AuNPs: gold nanorods, gold nanoshells, gold nanospheres, gold nanocages, and gold nanostars that have their application in photothermal therapy (PTT).

Gold nanoparticles in triple-negative breast cancer therapeutics

2021 ◽  
Vol 28 ◽  
Author(s):  
Zakia Akter ◽  
Fabiha Zaheen Khan ◽  
Md. Asaduzzaman Khan
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Triple Negative Breast Cancer ◽  
Mechanism Of Action ◽  
Targeted Delivery ◽  
Triple Negative ◽  
Cancer Therapeutics ◽  
In Vivo Studies

Background: Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer with enhanced metastasis and poor survival. Though chemotherapy, radiotherapy, photothermal therapy (PTT), photodynamic therapy (PDT), and gene delivery are used to treat TNBC, various side effects limit these therapeutics against TNBC. In this review article, we have focused on the mechanism of action of gold nanoparticles (AuNPs) to enhance the efficacy of therapeutics with targeted delivery on TNBC cells. Methods: Research data were accumulated from PubMed, Scopus, Web of Science, and Google Scholar using searching criteria “gold nanoparticles and triple-negative breast cancer” and “gold nanoparticles and cancer”. Though we reviewed many old papers, most cited papers were from the last ten years. Results: Various studies indicate that AuNPs can enhance bioavailability, site-specific drug delivery, and efficacy of chemotherapy, radiotherapy, PTT, and PDT as well as modulate gene expression. The role of AuNPs in the modulation of TNBC therapeutics through the inhibition of cell proliferation, progression, and metastasis has been proved in vitro and in vivo studies. As these mechanistic actions of AuNPs are most desirable to develop drugs with enhanced therapeutic efficacy against TNBC, it might be a promising approach to apply AuNPs for TNBC therapeutics. Conclusion: This article reviewed the mechanism of action of AuNPs and their application in the enhancement of therapeutics against TNBC. Much more attention is required for studying the role of AuNPs in developing them either as a single or synergistic anti-cancer agent against TNBC.

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