scholarly journals Anion transport properties of amine and amide-sidechained peptides are affected by charge and phospholipid composition

2008 ◽  
Vol 6 (16) ◽  
pp. 2914 ◽  
Author(s):  
Lei You ◽  
Ruiqiong Li ◽  
George W. Gokel
Keyword(s):  
Transport Properties ◽  
Phospholipid Composition ◽  
Anion Transport

scholarly journals Redox-controlled chalcogen-bonding at tellurium: impact on Lewis acidity and chloride anion transport properties

2020 ◽  
Vol 11 (28) ◽  
pp. 7495-7500 ◽  
Author(s):  
Benyu Zhou ◽  
François P. Gabbaï
Keyword(s):  
Transport Properties ◽  
Anion Transport ◽  
Chloride Anion ◽  
Lewis Acidity ◽  
Chalcogen Bond ◽  
Oxidative Alkylation

The oxidative alkylation of diorganotellurides enhances the chalcogen-bond donor properties of the tellurium center, an effect manifested in the enhanced chloride anion affinity and transport properties of the resulting telluronium cations.

scholarly journals Coumarin-bisureas as potent fluorescent transmembrane anion transporters

2021 ◽  
Author(s):  
Mohamed Fares ◽  
Xin Wu ◽  
Daniel A. McNaughton ◽  
Alexander M. Gilchrist ◽  
William Lewis ◽  
...  
Keyword(s):  
Transport Properties ◽  
Lipid Bilayer ◽  
Anion Transport ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes ◽  
Anion Transporters

A series of fluorescent coumarin bis-ureas have been synthesised and their anion transport properties studied. The compounds function as highly potent HCl co-transport agents in lipid bilayer membranes.

scholarly journals Anion transport across varying lipid membranes – the effect of lipophilicity

2015 ◽  
Vol 51 (23) ◽  
pp. 4883-4886 ◽  
Author(s):  
Michael J. Spooner ◽  
Philip A. Gale
Keyword(s):  
Transport Properties ◽  
Lipid Composition ◽  
Lipid Membranes ◽  
Anion Transport

The anion transport properties of a range of alkyl-substituted phenylthioureas were tested in vesicles of different lipid composition.

Differential Chloride Secretory Capacity in Transepithelial Ion Transport Properties in Chronic Rhinosinusitis

2020 ◽  
Vol 34 (6) ◽  
pp. 830-837
Author(s):  
Justin McCormick ◽  
Kyle Hoffman ◽  
Harrison Thompson ◽  
Daniel Skinner ◽  
Shaoyan Zhang ◽  
...  
Keyword(s):  
Ion Transport ◽  
Transport Properties ◽  
Chronic Rhinosinusitis ◽  
Anion Transport ◽  
Sinus Surgery ◽  
Mrna Levels ◽  
Ussing Chambers ◽  
Significant Difference ◽  
Epithelial Dysfunction ◽  
Secretory Capacity

Background Epithelial ion transport regulates hydration of airway mucosal surfaces, and thus promotes effective mucociliary clearance (MCC). Decreased transepithelial Cl− transport may contribute to epithelial dysfunction by abrogating MCC and increasing mucus viscosity in chronic rhinosinusitis (CRS). The objective of the current study is to evaluate Cl− channel transport properties from cultures of human sinonasal epithelia. Methods Human sinonasal epithelia (HSNE) from patients undergoing sinus surgery were cultured at an air-liquid interface to confluence and full differentiation. The epithelial monolayers were mounted in Ussing Chambers to investigate pharmacological manipulation of ion transport. Epithelial Na+ channel (via Amiloride), CFTR (via forskolin), and Ca2+-activated Cl− channel (CaCC, via UTP) transport were investigated among three different patient groups: Control, CRS and CRS with polyposis. CFTR mRNA levels were evaluated with quantitative RT-PCR. Results HSNE cultures from 18 patients (Control = 9, CRS = 6, CRS with polyposis = 3) were evaluated in 142 experiments. Summary data from the 18 patients demonstrated that stimulated CFTR-mediated anion transport (Δ ISC) was significantly lower with CRS (7.58+/−2.24 µA/cm2) compared to control (25.86+/−3.44 µA/cm2) and CRS with polyposis (20.16+/−4.0 µA/cm2) (p = 0.004). No statistically significant difference was found for CaCC anion transport between groups (p = 0.39). Significantly decreased mRNA (relative expression) was noted in CRS cultures (CRS = 40.83+/−1.76 vs. control = 116.2+/−24.27, p = 0.03). Conclusions A substantial decrease in the Cl− secretory capacity of HSNE monolayers was demonstrated in CRS subjects. Data suggest that CFTR may contribute more to abnormal ion transport in CRS than CaCC.

scholarly journals Altered Structure and Anion Transport Properties of Band 3 (AE1,SLC4A1) in Human Red Cells Lacking Glycophorin A

2003 ◽  
Vol 279 (4) ◽  
pp. 2414-2420 ◽  
Author(s):  
Lesley J. Bruce ◽  
Rui-jun Pan ◽  
Diane L. Cope ◽  
Makoto Uchikawa ◽  
Robert B. Gunn ◽  
...  
Keyword(s):  
Transport Properties ◽  
Band 3 ◽  
Anion Transport ◽  
Red Cells ◽  
Glycophorin A ◽  
Human Red Cells

PAH transport in rock crab urinary bladder. II. Luminal and serosal steps

1982 ◽  
Vol 242 (1) ◽  
pp. R25-R29
Author(s):  
C. W. Holliday ◽  
D. S. Miller
Keyword(s):  
Urinary Bladder ◽  
Transport Properties ◽  
Organic Anion ◽  
Ringer Solution ◽  
Anion Transport ◽  
Bromocresol Green ◽  
Organic Anion Transport ◽  
High Affinity ◽  
Luminal Membrane ◽  
Rock Crab

To characterize the organic anion transport properties of the luminal (1) and serosal (s) membranes of crab urinary bladder, initial (10 min) fluxes (J) and tissue accumulations (Ac) of 10 microM PAH were measured in the absence and presence of 1 mM BCG (nontransported, high-affinity competitor). Control bladders exhibited net reabsorptive transport with a mean Jl leads to s/Js leads to 1 of about 7; concentrative transport of p-aminohippuric acid (PAH) occurred only across the luminal cell (c) membrane. With luminal PAH, luminal bromocresol green (BCG) reduced Jl leads to c, Jc leads to s, and Ac by about 85%; serosal BCG reduced Jc leads to s, increased Ac but had no effect on Jl leads to c. With serosal PAH, serosal BCG reduced Js leads to c, Jc leads to l, and Ac; luminal BCG had no effects on either fluxes or tissue accumulation. When bladder sheets were loaded with radiolabeled PAH, mounted in a chamber, and exposed to flowing crab Ringer solution on both sides, Jc leads to s was nearly twice as large as Jc leads to l; BCG significantly reduced Jc leads to s but not Jc leads to l. With unlabeled PAH in the efflux media, Jc leads to s was increased. The data are consistent with a model featuring an inwardly directed pump at the luminal membrane, a facilitated carrier at the serosal membrane, and nonmediated pathways at both membranes.

scholarly journals Fluorescent transmembrane anion transporters: shedding light on anionophoric activity in cells

2016 ◽  
Vol 7 (8) ◽  
pp. 5069-5077 ◽  
Author(s):  
Stuart N. Berry ◽  
Vanessa Soto-Cerrato ◽  
Ethan N. W. Howe ◽  
Harriet J. Clarke ◽  
Ishna Mistry ◽  
...  
Keyword(s):  
Transport Properties ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Anion Transport ◽  
Anion Transporters ◽  
In Cells

A series of fluorescent anion transporters have been synthesised and their anion transport properties and interactions with cancer cell lines studied.

scholarly journals Aromatic isophthalamides aggregate in lipid bilayers: evidence for a cooperative transport mechanism

2015 ◽  
Vol 13 (10) ◽  
pp. 3136-3143 ◽  
Author(s):  
Stuart N. Berry ◽  
Nathalie Busschaert ◽  
Charlotte L. Frankling ◽  
Dale Salter ◽  
Philip A. Gale
Keyword(s):  
Transport Properties ◽  
Lipid Bilayers ◽  
Transport Mechanism ◽  
Anion Transport ◽  
Anion Transporters ◽  
Cooperative Transport

The synthesis and anion transport properties of a series of aromatic transmembrane anion transporters based on an isophthalamide scaffold are reported.

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