The novel and efficient direct synthesis of N,O-acetal compounds using a hypervalent iodine(iii) reagent: an improved synthetic method for a key intermediate of discorhabdins

2005 ◽  
pp. 1764 ◽  
Author(s):  
Yu Harayama ◽  
Masako Yoshida ◽  
Daigo Kamimura ◽  
Yasuyuki Kita
Keyword(s):  
Direct Synthesis ◽  
Hypervalent Iodine ◽  
Synthetic Method ◽  
The Novel

scholarly journals PIDA-mediated intramolecular oxidative C–N bond formation for the direct synthesis of quinoxalines from enaminones

RSC Advances ◽  
2019 ◽  
Vol 9 (14) ◽  
pp. 7718-7722 ◽  
Author(s):  
Hong Zhang ◽  
Jinhai Shen ◽  
Zhenhui Yang ◽  
Xiuling Cui
Keyword(s):  
Direct Synthesis ◽  
Bond Formation ◽  
Hypervalent Iodine ◽  
Mild Conditions

An expedient hypervalent iodine(iii)-mediated approach to obtain substituted quinoxalines from readily available enaminones has been developed under mild conditions.

scholarly journals Straightforward Strategies for the Preparation of NH-Sulfox­imines: A Serendipitous Story

Synlett ◽  
2017 ◽  
Vol 28 (19) ◽  
pp. 2525-2538 ◽  
Author(s):  
James Bull ◽  
Renzo Luisi ◽  
Leonardo Degennaro
Keyword(s):  
Transition Metal ◽  
Physicochemical Properties ◽  
Direct Synthesis ◽  
Transition Metal Catalysts ◽  
Hypervalent Iodine ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
Recent Developments ◽  
New Procedures

Sulfoximines are emerging as valuable new isosteres for use in medicinal chemistry, with the potential to modulate physicochemical properties. Recent developments in synthetic strategies have made the unprotected ‘free’ NH-sulfoximine group more readily available, facilitating further study. This account reviews approaches to NH-sulfoximines, with a focus on our contribution to the field. Starting from the development of catalytic strategies involving transition metals, more sustainable metal-free processes have been discovered. In particular, the use of hypervalent iodine reagents to mediate NH-transfer to sulfoxides is described, along with an assessment of the substrate scope. Furthermore, a one-pot strategy to convert sulfides directly into NH-sulfoximines is discussed, with N- and O-transfer occurring under the reaction conditions. Mechanistic evidence for the new procedures is included as well as relevant synthetic applications that further exemplify the potential of these approaches.1 Introduction2 Strategies to Form NH-Sulfoximines Involving Transition-Metal Catalysts3 Metal-Free Strategies to Prepare NH-Sulfoximines4 Mechanistic Evidence for the Direct Synthesis of NH-Sulfoximines from Sulfoxides and Sulfides5 Further Applications6 Conclusion

scholarly journals Direct Synthesis and Applications of Solid Silylzinc Reagents

2021 ◽  
Author(s):  
Ramesh Rasappan ◽  
Revathi Chandrasekaran ◽  
Feba Thomas Pulikkottil ◽  
Krishna Suresh
Keyword(s):  
Detrimental Effect ◽  
Functional Group ◽  
Direct Synthesis ◽  
Cross Coupling ◽  
Synthetic Methods ◽  
Synthetic Method ◽  
General Applicability ◽  
Alkyl Aryl ◽  
Synthetic Utility ◽  
First Time

The increased synthetic utility of organosilanes motivates researchers to develop a milder and more practical synthetic methods. Silylzinc reagents, which are typically the most functional group tolerant, are notoriously difficult to synthesize because they are obtained by a pyrophoric reaction of silyllithium, particularly Me3 SiLi itself prepared by the reaction of MeLi and disilane. Furthermore, the dissolved LiCl in silylzinc may have a detrimental effect. A synthetic method that can avoid silyllithium and involves a direct synthesis of silylzinc reagents from silyl halides is arguably the simplest and economical strategy. We describe for the first time, the direct synthesis of PhMe2 SiZnI and Me3 SiZnI reagents by employing a coordinating TMEDA ligand, as well as single crystal XRD structures. Importantly, they can be obtained as solid and stored for longer periods of time. We demonstrate their significance in cross-coupling of various free alkyl/aryl/alkenyl carboxylic acids with broader functional group tolerance and API derivatives. The general applicability and efficiency of solid Me3 SiZnI are shown in a wide variety of reactions including alkylation, arylation, allylation, 1,4-addition, acylation and more.

Direct synthesis of graphene quantum dots on hexagonal boron nitride substrate

2014 ◽  
Vol 2 (19) ◽  
pp. 3717-3722 ◽  
Author(s):  
Xuli Ding
Keyword(s):  
Quantum Dots ◽  
Boron Nitride ◽  
Hexagonal Boron Nitride ◽  
Direct Synthesis ◽  
Graphene Quantum Dots ◽  
Metal Catalyst ◽  
The Novel

The novel PL properties of GQDs synthesized on h-BN by CVD without any metal catalyst were revealed.

Hypervalent iodine oxidation of trimethylsilyl enol ethers of ketones: A direct synthesis of α-keto triflates

1989 ◽  
Vol 30 (6) ◽  
pp. 667-670 ◽  
Author(s):  
Robert M. Moriarty ◽  
W. Ruwan Epa ◽  
Raju Penmasta ◽  
Alok K. Awasthi
Keyword(s):  
Direct Synthesis ◽  
Hypervalent Iodine ◽  
Enol Ethers
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