scholarly journals Selective loss of parvalbumin-positive GABAergic interneurons in the cerebral cortex of maternally stressed Gad1-heterozygous mouse offspring

2014 ◽  
Vol 4 (3) ◽  
pp. e371-e371 ◽  
Author(s):  
T Uchida ◽  
T Furukawa ◽  
S Iwata ◽  
Y Yanagawa ◽  
A Fukuda
Keyword(s):  
Cerebral Cortex ◽  
Gabaergic Interneurons ◽  
Heterozygous Mouse ◽  
Selective Loss

scholarly journals Early emergence of cortical interneuron diversity in the mouse embryo

Science ◽  
2018 ◽  
Vol 360 (6384) ◽  
pp. 81-85 ◽  
Author(s):  
Da Mi ◽  
Zhen Li ◽  
Lynette Lim ◽  
Mingfeng Li ◽  
Monika Moissidis ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Progenitor Cells ◽  
Mouse Embryo ◽  
Neural Circuit ◽  
Aminobutyric Acid ◽  
Gabaergic Interneurons ◽  
Cortical Interneuron ◽  
Cortical Interneurons ◽  
Newborn Neurons ◽  
Functionally Diverse

GABAergic interneurons (GABA, γ-aminobutyric acid) regulate neural-circuit activity in the mammalian cerebral cortex. These cortical interneurons are structurally and functionally diverse. Here, we use single-cell transcriptomics to study the origins of this diversity in the mouse. We identify distinct types of progenitor cells and newborn neurons in the ganglionic eminences, the embryonic proliferative regions that give rise to cortical interneurons. These embryonic precursors show temporally and spatially restricted transcriptional patterns that lead to different classes of interneurons in the adult cerebral cortex. Our findings suggest that shortly after the interneurons become postmitotic, their diversity is already patent in their diverse transcriptional programs, which subsequently guide further differentiation in the developing cortex.

Selective Loss and Axonal Sprouting of GABAergic Interneurons in the Sclerotic Hippocampus Induced by LiCl–Pilocarpine

2010 ◽  
Vol 121 (2) ◽  
pp. 69-85 ◽  
Author(s):  
Lili Long ◽  
Bo Xiao ◽  
Li Feng ◽  
Fang Yi ◽  
Guoliang Li ◽  
...  
Keyword(s):  
Gabaergic Interneurons ◽  
Axonal Sprouting ◽  
Selective Loss

scholarly journals Characterization and Stage-Dependent Lineage Analysis of Intermediate Progenitors of Cortical GABAergic Interneurons

2021 ◽  
Vol 15 ◽  
Author(s):  
Shigeyuki Esumi ◽  
Makoto Nasu ◽  
Takeshi Kawauchi ◽  
Koichiro Miike ◽  
Kento Morooka ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Lineage Tracing ◽  
Adult Brain ◽  
Inhibitory Neurons ◽  
Gabaergic Interneurons ◽  
Ganglionic Eminence ◽  
Cortical Layers ◽  
Intermediate Progenitors ◽  
Mouse Cerebral Cortex ◽  
Lineage Analysis

Intermediate progenitors of both excitatory and inhibitory neurons, which can replenish neurons in the adult brain, were recently identified. However, the generation of intermediate progenitors of GABAergic inhibitory neurons (IPGNs) has not been studied in detail. Here, we characterized the spatiotemporal distribution of IPGNs in mouse cerebral cortex. IPGNs generated neurons during both embryonic and postnatal stages, but the embryonic IPGNs were more proliferative. Our lineage tracing analyses showed that the embryonically proliferating IPGNs tended to localize to the superficial layers rather than the deep cortical layers at 3 weeks after birth. We also found that embryonic IPGNs derived from the medial and caudal ganglionic eminence (CGE) but more than half of the embryonic IPGNs were derived from the CGE and broadly distributed in the cerebral cortex. Taken together, our data indicate that the broadly located IPGNs during embryonic and postnatal stages exhibit a different proliferative property and layer distribution.

Selective loss of the NMDA receptor complex in the cerebral cortex and hippocampus of aged rats

1991 ◽  
Vol 16 ◽  
pp. 101
Author(s):  
Masao Tamaru ◽  
Yukio Yoneda ◽  
Kiyokazu Ogita ◽  
Jun Shimizu ◽  
Yutaka Nagata
Keyword(s):  
Cerebral Cortex ◽  
Nmda Receptor ◽  
Receptor Complex ◽  
Aged Rats ◽  
Selective Loss ◽  
Nmda Receptor Complex
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