scholarly journals Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex

2008 ◽  
Vol 9 (7) ◽  
pp. 557-568 ◽  
Author(s):  
Keyword(s):  
Cerebral Cortex ◽  
Gabaergic Interneurons

scholarly journals Early emergence of cortical interneuron diversity in the mouse embryo

Science ◽  
2018 ◽  
Vol 360 (6384) ◽  
pp. 81-85 ◽  
Author(s):  
Da Mi ◽  
Zhen Li ◽  
Lynette Lim ◽  
Mingfeng Li ◽  
Monika Moissidis ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Progenitor Cells ◽  
Mouse Embryo ◽  
Neural Circuit ◽  
Aminobutyric Acid ◽  
Gabaergic Interneurons ◽  
Cortical Interneuron ◽  
Cortical Interneurons ◽  
Newborn Neurons ◽  
Functionally Diverse

GABAergic interneurons (GABA, γ-aminobutyric acid) regulate neural-circuit activity in the mammalian cerebral cortex. These cortical interneurons are structurally and functionally diverse. Here, we use single-cell transcriptomics to study the origins of this diversity in the mouse. We identify distinct types of progenitor cells and newborn neurons in the ganglionic eminences, the embryonic proliferative regions that give rise to cortical interneurons. These embryonic precursors show temporally and spatially restricted transcriptional patterns that lead to different classes of interneurons in the adult cerebral cortex. Our findings suggest that shortly after the interneurons become postmitotic, their diversity is already patent in their diverse transcriptional programs, which subsequently guide further differentiation in the developing cortex.

scholarly journals Characterization and Stage-Dependent Lineage Analysis of Intermediate Progenitors of Cortical GABAergic Interneurons

2021 ◽  
Vol 15 ◽  
Author(s):  
Shigeyuki Esumi ◽  
Makoto Nasu ◽  
Takeshi Kawauchi ◽  
Koichiro Miike ◽  
Kento Morooka ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Lineage Tracing ◽  
Adult Brain ◽  
Inhibitory Neurons ◽  
Gabaergic Interneurons ◽  
Ganglionic Eminence ◽  
Cortical Layers ◽  
Intermediate Progenitors ◽  
Mouse Cerebral Cortex ◽  
Lineage Analysis

Intermediate progenitors of both excitatory and inhibitory neurons, which can replenish neurons in the adult brain, were recently identified. However, the generation of intermediate progenitors of GABAergic inhibitory neurons (IPGNs) has not been studied in detail. Here, we characterized the spatiotemporal distribution of IPGNs in mouse cerebral cortex. IPGNs generated neurons during both embryonic and postnatal stages, but the embryonic IPGNs were more proliferative. Our lineage tracing analyses showed that the embryonically proliferating IPGNs tended to localize to the superficial layers rather than the deep cortical layers at 3 weeks after birth. We also found that embryonic IPGNs derived from the medial and caudal ganglionic eminence (CGE) but more than half of the embryonic IPGNs were derived from the CGE and broadly distributed in the cerebral cortex. Taken together, our data indicate that the broadly located IPGNs during embryonic and postnatal stages exhibit a different proliferative property and layer distribution.

Proliferation of GABAergic interneurons but not cortical plate cells was reduced by maternal stress in the fetal cerebral cortex

2009 ◽  
Vol 65 ◽  
pp. S185
Author(s):  
Taku Uchida ◽  
Toshitaka Morishima ◽  
Tomonori Furukawa ◽  
Yutaka Oki ◽  
Kiyoshi Egawa ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Maternal Stress ◽  
Cortical Plate ◽  
Gabaergic Interneurons
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