scholarly journals Multidirectional and multizonal tangential migration of GABAergic interneurons in the developing cerebral cortex

Development ◽  
2006 ◽  
Vol 133 (11) ◽  
pp. 2167-2176 ◽  
Author(s):  
D. H. Tanaka
Keyword(s):  
Cerebral Cortex ◽  
Gabaergic Interneurons ◽  
Tangential Migration

scholarly journals 20-P016 Smad-interacting protein-1 (Sip1/Zfhx1b) is crucial for tangential migration of gabaergic interneurons

2009 ◽  
Vol 126 ◽  
pp. S309
Author(s):  
Veronique van den Berghe ◽  
André Goffinet ◽  
Rüdiger Klein ◽  
Nicoletta Kessaris ◽  
Kenneth Campbell ◽  
...  
Keyword(s):  
Gabaergic Interneurons ◽  
Interacting Protein ◽  
Tangential Migration

Tangential migration of neurons in the developing cerebral cortex

Development ◽  
1995 ◽  
Vol 121 (7) ◽  
pp. 2165-2176 ◽  
Author(s):  
N.A. O'Rourke ◽  
D.P. Sullivan ◽  
C.E. Kaznowski ◽  
A.A. Jacobs ◽  
S.K. McConnell
Keyword(s):  
Cerebral Cortex ◽  
Neuronal Migration ◽  
Ventricular Zone ◽  
Brain Slices ◽  
Cortical Plate ◽  
Tangential Migration ◽  
Cortical Regions ◽  
Intact Cortex ◽  
Migrating Cells

The mammalian cerebral cortex is divided into functionally distinct areas. Although radial patterns of neuronal migration have been thought to be essential for patterning these areas, direct observation of migrating cells in cortical brain slices has revealed that cells follow both radial and nonradial pathways as they travel from their sites of origin in the ventricular zone out to their destinations in the cortical plate (O'Rourke, N.A., Dailey, M.E., Smith, S.J. and McConnell, S.K. (1992) Science 258, 299–302). These findings suggested that neurons may not be confined to radial migratory pathways in vivo. Here, we have examined the patterns of neuronal migration in the intact cortex. Analysis of the orientations of [3H]thymidine-labeled migrating cells suggests that nonradial migration is equally common in brain slices and the intact cortex and that it increases during neurogenesis. Additionally, cells appear to follow nonradial trajectories at all levels of the developing cerebral wall, suggesting that tangential migration may be more prevalent than previously suspected from the imaging studies. Immunostaining with neuron-specific antibodies revealed that many tangentially migrating cells are young neurons. These results suggest that tangential migration in the intact cortex plays a pivotal role in the tangential dispersion of clonally related cells revealed by retroviral lineage studies (Walsh, C. and Cepko, C. L. (1992) Science 255, 434–440). Finally, we examined possible substrata for nonradial migration in dorsal cortical regions where the majority of glia extend radially. Using confocal and electron microscopy, we found that nonradially oriented cells run perpendicular to glial processes and make glancing contacts with them along their leading processes. Thus, if nonradial cells utilize glia as a migratory substratum they must glide across one glial fiber to another. Examination of the relationships between migratory cells and axons revealed axonal contacts with both radial and nonradial cells. These results suggest that nonradial cells use strategies and substrata for migration that differ from those employed by radial cells.

scholarly journals Early emergence of cortical interneuron diversity in the mouse embryo

Science ◽  
2018 ◽  
Vol 360 (6384) ◽  
pp. 81-85 ◽  
Author(s):  
Da Mi ◽  
Zhen Li ◽  
Lynette Lim ◽  
Mingfeng Li ◽  
Monika Moissidis ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Progenitor Cells ◽  
Mouse Embryo ◽  
Neural Circuit ◽  
Aminobutyric Acid ◽  
Gabaergic Interneurons ◽  
Cortical Interneuron ◽  
Cortical Interneurons ◽  
Newborn Neurons ◽  
Functionally Diverse

GABAergic interneurons (GABA, γ-aminobutyric acid) regulate neural-circuit activity in the mammalian cerebral cortex. These cortical interneurons are structurally and functionally diverse. Here, we use single-cell transcriptomics to study the origins of this diversity in the mouse. We identify distinct types of progenitor cells and newborn neurons in the ganglionic eminences, the embryonic proliferative regions that give rise to cortical interneurons. These embryonic precursors show temporally and spatially restricted transcriptional patterns that lead to different classes of interneurons in the adult cerebral cortex. Our findings suggest that shortly after the interneurons become postmitotic, their diversity is already patent in their diverse transcriptional programs, which subsequently guide further differentiation in the developing cortex.

scholarly journals Arx Is a Direct Target of Dlx2 and Thereby Contributes to the Tangential Migration of GABAergic Interneurons

2008 ◽  
Vol 28 (42) ◽  
pp. 10674-10686 ◽  
Author(s):  
G. Colasante ◽  
P. Collombat ◽  
V. Raimondi ◽  
D. Bonanomi ◽  
C. Ferrai ◽  
...  
Keyword(s):  
Gabaergic Interneurons ◽  
Tangential Migration ◽  
Direct Target

Stromal-Derived Factor 1 Signalling Regulates Radial and Tangential Migration in the Developing Cerebral Cortex

2007 ◽  
Vol 30 (1-3) ◽  
pp. 117-131 ◽  
Author(s):  
Anastasia Liapi ◽  
James Pritchett ◽  
Owen Jones ◽  
Nobutaka Fujii ◽  
John G. Parnavelas ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Tangential Migration

scholarly journals Characterization and Stage-Dependent Lineage Analysis of Intermediate Progenitors of Cortical GABAergic Interneurons

2021 ◽  
Vol 15 ◽  
Author(s):  
Shigeyuki Esumi ◽  
Makoto Nasu ◽  
Takeshi Kawauchi ◽  
Koichiro Miike ◽  
Kento Morooka ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Lineage Tracing ◽  
Adult Brain ◽  
Inhibitory Neurons ◽  
Gabaergic Interneurons ◽  
Ganglionic Eminence ◽  
Cortical Layers ◽  
Intermediate Progenitors ◽  
Mouse Cerebral Cortex ◽  
Lineage Analysis

Intermediate progenitors of both excitatory and inhibitory neurons, which can replenish neurons in the adult brain, were recently identified. However, the generation of intermediate progenitors of GABAergic inhibitory neurons (IPGNs) has not been studied in detail. Here, we characterized the spatiotemporal distribution of IPGNs in mouse cerebral cortex. IPGNs generated neurons during both embryonic and postnatal stages, but the embryonic IPGNs were more proliferative. Our lineage tracing analyses showed that the embryonically proliferating IPGNs tended to localize to the superficial layers rather than the deep cortical layers at 3 weeks after birth. We also found that embryonic IPGNs derived from the medial and caudal ganglionic eminence (CGE) but more than half of the embryonic IPGNs were derived from the CGE and broadly distributed in the cerebral cortex. Taken together, our data indicate that the broadly located IPGNs during embryonic and postnatal stages exhibit a different proliferative property and layer distribution.

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