scholarly journals Development of a conditional liver tumor model by mifepristone-inducible Cre recombination to control oncogenic krasV12 expression in transgenic zebrafish

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Anh Tuan Nguyen ◽  
Vivien Koh ◽  
Jan M. Spitsbergen ◽  
Zhiyuan Gong
Keyword(s):  
Liver Tumor ◽  
Tumor Model ◽  
Transgenic Zebrafish ◽  
Cre Recombination

scholarly journals Theranostic application of lipiodol for transarterial chemoembolization in a VX2 rabbit liver tumor model

Theranostics ◽  
2019 ◽  
Vol 9 (13) ◽  
pp. 3674-3686 ◽  
Author(s):  
Johanna Maria Mijntje van Breugel ◽  
Jean-François Geschwind ◽  
Sahar Mirpour ◽  
Lynn Jeanette Savic ◽  
Xuchen Zhang ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Transarterial Chemoembolization ◽  
Tumor Model ◽  
Rabbit Liver

Correlation between Hepatic Tumor Blood Flow and Glucose Utilization in a Rabbit Liver Tumor Model

Radiology ◽  
2006 ◽  
Vol 239 (3) ◽  
pp. 740-750 ◽  
Author(s):  
Errol E. Stewart ◽  
Xaiogang Chen ◽  
Jennifer Hadway ◽  
Ting-Yim Lee
Keyword(s):  
Blood Flow ◽  
Liver Tumor ◽  
Glucose Utilization ◽  
Tumor Model ◽  
Hepatic Tumor ◽  
Rabbit Liver ◽  
Tumor Blood Flow

Augmentation of Chemotherapeutic Infusion Effect by TSU-68, an Oral Targeted Antiangiogenic Agent, in a Rabbit VX2 Liver Tumor Model

2010 ◽  
Vol 35 (1) ◽  
pp. 168-175 ◽  
Author(s):  
Hyo-Cheol Kim ◽  
Jin Wook Chung ◽  
Seung Hong Choi ◽  
Seock-Ah Im ◽  
Yasundo Yamasaki ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Tumor Model ◽  
Antiangiogenic Agent ◽  
Chemotherapeutic Infusion

Imaging of hypoxia-driven gene expression in an orthotopic liver tumor model

2007 ◽  
Vol 6 (11) ◽  
pp. 2900-2908 ◽  
Author(s):  
Peter Brader ◽  
Christopher Cesare Riedl ◽  
Yanghee Woo ◽  
Vladimir Ponomarev ◽  
Pat Zanzonico ◽  
...  
Keyword(s):  
Gene Expression ◽  
Liver Tumor ◽  
Tumor Model

Liver Tumor Model with Implanted Rhabdomyosarcoma in Rats: MR Imaging, Microangiography, and Histopathologic Analysis

Radiology ◽  
2006 ◽  
Vol 239 (2) ◽  
pp. 554-562 ◽  
Author(s):  
Feng Chen ◽  
Xihe Sun ◽  
Frederik De Keyzer ◽  
Jie Yu ◽  
Ronald Peeters ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Liver Tumor ◽  
Tumor Model ◽  
Histopathologic Analysis

Transarterial Chemoembolization Using Sorafenib in a Rabbit VX2 Liver Tumor Model: Pharmacokinetics and Antitumor Effect

2016 ◽  
Vol 27 (7) ◽  
pp. 1086-1092 ◽  
Author(s):  
Gyoung Min Kim ◽  
Man Deuk Kim ◽  
Do Young Kim ◽  
Se Hoon Kim ◽  
Jong Yun Won ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Transarterial Chemoembolization ◽  
Antitumor Effect ◽  
Tumor Model

Percutaneous liquid ablation agent for tumor treatment and drug delivery

2021 ◽  
Vol 13 (580) ◽  
pp. eabe3889
Author(s):  
Hassan Albadawi ◽  
Zefu Zhang ◽  
Izzet Altun ◽  
Jingjie Hu ◽  
Leila Jamal ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Ionic Liquid ◽  
Liver Tumor ◽  
Thermal Ablation ◽  
Liver Tumors ◽  
Low Cost ◽  
Drug Distribution ◽  
Tumor Model ◽  
Ablation Zone ◽  
Synergistic Cytotoxicity

Percutaneous locoregional therapies (LRTs), such as thermal ablation, are performed to limit the progression of hepatocellular carcinoma (HCC) and offer a bridge for patients waiting for liver transplantation. However, physiological challenges related to tumor location, size, and existence of multiple lesions as well as safety concerns related to potential thermal injury to adjacent tissues may preclude the use of thermal ablation or lead to its failure. Here, we showed a successful injection of an ionic liquid into tissue under image guidance, ablation of tumors in response to the injected ionic liquid, and persistence (28 days) of coinjected chemotherapy with the ionic liquid in the ablation zone. In a rat HCC model, the rabbit VX2 liver tumor model, and 12 human resected tumors, injection of the ionic liquid led to consistent tumor ablation. Combining the ionic liquid with the chemotherapy agent, doxorubicin, resulted in synergistic cytotoxicity when tested with cultured HCC cells and uniform drug distribution throughout the ablation zone when percutaneously injected into liver tumors in the rabbit liver tumor model. Because this ionic liquid preparation is simple to use, is efficacious, and has a low cost, we propose that this new LRT may bridge more patients to liver transplantation.

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