Transarterial Chemoembolization Using Sorafenib in a Rabbit VX2 Liver Tumor Model: Pharmacokinetics and Antitumor Effect

2016 ◽  
Vol 27 (7) ◽  
pp. 1086-1092 ◽  
Author(s):  
Gyoung Min Kim ◽  
Man Deuk Kim ◽  
Do Young Kim ◽  
Se Hoon Kim ◽  
Jong Yun Won ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Transarterial Chemoembolization ◽  
Antitumor Effect ◽  
Tumor Model

scholarly journals Theranostic application of lipiodol for transarterial chemoembolization in a VX2 rabbit liver tumor model

Theranostics ◽  
2019 ◽  
Vol 9 (13) ◽  
pp. 3674-3686 ◽  
Author(s):  
Johanna Maria Mijntje van Breugel ◽  
Jean-François Geschwind ◽  
Sahar Mirpour ◽  
Lynn Jeanette Savic ◽  
Xuchen Zhang ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Transarterial Chemoembolization ◽  
Tumor Model ◽  
Rabbit Liver

scholarly journals FDG-PET for Evaluating the Antitumor Effect of Intraarterial 3-Bromopyruvate Administration in a Rabbit VX2 Liver Tumor Model

2007 ◽  
Vol 8 (3) ◽  
pp. 216 ◽  
Author(s):  
Hee Sun Park ◽  
Jin Wook Chung ◽  
Hwan Jun Jae ◽  
Young Il Kim ◽  
Kyu Ri Son ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Fdg Pet ◽  
Antitumor Effect ◽  
Tumor Model

Antitumor effect of miriplatin-lipiodol suspension/emulsion using a VX2 liver tumor model

2013 ◽  
Vol 31 (10) ◽  
pp. 662-667 ◽  
Author(s):  
Yuki Tomozawa ◽  
Norihisa Nitta ◽  
Shinji Ohta ◽  
Hideji Otani ◽  
Shobu Watanabe ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Antitumor Effect ◽  
Tumor Model

Comparison of metabolic and immunologic responses to transarterial chemoembolization with different chemoembolic regimens in a rabbit VX2 liver tumor model

2021 ◽  
Author(s):  
Luzie A. Doemel ◽  
Jessica G. Santana ◽  
Lynn J. Savic ◽  
Fabian M. Laage Gaupp ◽  
Tabea Borde ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Transarterial Chemoembolization ◽  
Tumor Model

scholarly journals Murine hepatoma treatment with mature dendritic cells stimulated by Trichinella spiralis excretory/secretory products

Parasite ◽  
2020 ◽  
Vol 27 ◽  
pp. 47
Author(s):  
Jing Ding ◽  
Xiaolei Liu ◽  
Bin Tang ◽  
Xue Bai ◽  
Yang Wang ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Tumor Growth ◽  
Antitumor Effect ◽  
Trichinella Spiralis ◽  
Critical Role ◽  
Tumor Model ◽  
Control Group ◽  
Tumor Inhibition ◽  
Significant Difference ◽  
Secretory Products

Excretory/Secretory Products (ESPs) of the nematode Trichinella spiralis contain antitumor-active substances that inhibit tumor growth. Mature dendritic cells (DCs) play a critical role in the antitumor immunity of the organism. As pathogen-derived products, it ought to be discussed whether T. spiralis ESPs will reduce the antitumor effect of mature DCs from the host before it is applied to patients’ tumors. Therefore, the aim of this work was to evaluate the immunological effect of DCs stimulated by T. spiralis ESPs in H22 tumor-bearing mice. H22 tumor model mice in this study were randomly divided into four groups according to the treatment: PBS control group, ESP group, DCs group, and DCs stimulated with T. spiralis ESP (ESP+DCs group). The antitumor effect was evaluated by tumor inhibition rate and cytokine detection using ELISA. The results showed significant inhibition in tumor growth in the ESP+DCs, DCs and ESP groups when compared with the PBS control group (p < 0.01, p < 0.01, and p < 0.05, respectively). However, no significant difference was observed on tumor inhibition rates between the ESP+DCs and DCs groups. The decrease in IL-4, IL-6, and IL-10, and the increase in IFN-γ between the DCs and ESP+DCs groups were also not significant. Therefore, DCs stimulated by ESP did not reduce the antitumor effect of mature DCs, which demonstrated that the T. spiralis ESP would not affect the antitumor effect of mature DCs by modulating the immune response of the host, and that ESPs are safe in antitumor immunology when applied in a tumor model mice.

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