scholarly journals Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Lan Chang ◽  
Wei Cui ◽  
Yong Yang ◽  
Shujun Xu ◽  
Wenhua Zhou ◽  
...  
Keyword(s):  
Memory Impairments ◽  
Β Amyloid ◽  
Amyloid Assembly

Fucoxanthin Inhibits β-Amyloid Assembly and Attenuates β-Amyloid Oligomer-Induced Cognitive Impairments

2017 ◽  
Vol 65 (20) ◽  
pp. 4092-4102 ◽  
Author(s):  
Siying Xiang ◽  
Fufeng Liu ◽  
Jiajia Lin ◽  
Huixin Chen ◽  
Chunhui Huang ◽  
...  
Keyword(s):  
Cognitive Impairments ◽  
Β Amyloid ◽  
Amyloid Assembly ◽  
Amyloid Oligomer

Release of acetylcholinesterase (AChE) from β-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice

2008 ◽  
Vol 175 (1-3) ◽  
pp. 142-149 ◽  
Author(s):  
Margarita C. Dinamarca ◽  
Macarena Arrázola ◽  
Enrique Toledo ◽  
Waldo F. Cerpa ◽  
Juan Hancke ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Spatial Memory ◽  
Amyloid Plaques ◽  
Memory Impairments ◽  
Β Amyloid

Aromatic-interaction-mediated inhibition of β-amyloid assembly structures and cytotoxicity

2017 ◽  
Vol 23 (9) ◽  
pp. 679-684 ◽  
Author(s):  
Hanyi Xie ◽  
Jiaxi Peng ◽  
Changliang Liu ◽  
Xiaocui Fang ◽  
Hongyang Duan ◽  
...  
Keyword(s):  
Β Amyloid ◽  
Amyloid Assembly ◽  
Aromatic Interaction

Aqueous Date Fruit Extract can’t Ameliorate β-amyloid Induced Memory Impairments in Male Rats

2017 ◽  
Vol 17 (2) ◽  
pp. 69-75
Author(s):  
Fatemeh Mehdipour ◽  
Nader Shahrokhi ◽  
Khadijeh Esmaeilpou ◽  
Taj Pari Kalantarip ◽  
Hakime Oloumi ◽  
...  
Keyword(s):  
Male Rats ◽  
Fruit Extract ◽  
Memory Impairments ◽  
Date Fruit ◽  
Β Amyloid

scholarly journals NMR-based site-resolved profiling of β-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril

2019 ◽  
Vol 295 (2) ◽  
pp. 458-467 ◽  
Author(s):  
Yiling Xiao ◽  
Isamu Matsuda ◽  
Masafumi Inoue ◽  
Tomoya Sasahara ◽  
Minako Hoshi ◽  
...  
Keyword(s):  
Chemical Shifts ◽  
Structural Transitions ◽  
Limited Information ◽  
Distance Measurements ◽  
Tem Analysis ◽  
Negative Stain ◽  
Large Conformational Change ◽  
Β Amyloid ◽  
Amyloid Assembly ◽  
Β Sheet

Increasing evidence highlights the central role of neurotoxic oligomers of the 42-residue-long β-amyloid (Aβ42) in Alzheimer's disease (AD). However, very limited information is available on the structural transition from oligomer to fibril, particularly for pathologically relevant amyloids. To the best of our knowledge, we present here the first site-specific structural characterization of Aβ42 misfolding, from toxic oligomeric assembly yielding a similar conformation to an AD-associated Aβ42 oligomer, into a fibril. Transmission EM (TEM) analysis revealed that a spherical amyloid assembly (SPA) of Aβ42 with a 15.6 ± 2.1-nm diameter forms in a ∼30-μm Aβ42 solution after a ∼10-h incubation at 4 °C, followed by a slow conversion into fibril at ∼180 h. Immunological analysis suggested that the SPA has a surface structure similar to that of amylospheroid (ASPD), a patient-derived toxic Aβ oligomer, which had a diameter of 10–15 nm in negative-stain TEM. Solid-state NMR analyses indicated that the SPA structure involves a β-loop-β motif, which significantly differed from the triple-β motif observed for the Aβ42 fibril. The comparison of the 13C chemical shifts of SPA with those of the fibril prepared in the above conditions and interstrand distance measurements suggested a large conformational change involving rearrangements of intermolecular β-sheet into in-register parallel β-sheet during the misfolding. A comparison of the SPA and ASPD 13C chemical shifts indicated that SPA is structurally similar to the ASPD relevant to AD. These observations provide insights into the architecture and key structural transitions of amyloid oligomers relevant for AD pathology.

scholarly journals Hyperforin prevents β-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-β-deposits

2006 ◽  
Vol 11 (11) ◽  
pp. 1032-1048 ◽  
Author(s):  
M C Dinamarca ◽  
W Cerpa ◽  
J Garrido ◽  
J L Hancke ◽  
N C Inestrosa
Keyword(s):  
Spatial Memory ◽  
Amyloid Β ◽  
Memory Impairments ◽  
Β Amyloid
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