Fucoxanthin Inhibits β-Amyloid Assembly and Attenuates β-Amyloid Oligomer-Induced Cognitive Impairments

2017 ◽  
Vol 65 (20) ◽  
pp. 4092-4102 ◽  
Author(s):  
Siying Xiang ◽  
Fufeng Liu ◽  
Jiajia Lin ◽  
Huixin Chen ◽  
Chunhui Huang ◽  
...  
Keyword(s):  
Cognitive Impairments ◽  
Β Amyloid ◽  
Amyloid Assembly ◽  
Amyloid Oligomer

scholarly journals MiR-144 promotes β-amyloid accumulation-induced cognitive impairments by targeting ADAM10 following traumatic brain injury

Oncotarget ◽  
2017 ◽  
Vol 8 (35) ◽  
pp. 59181-59203 ◽  
Author(s):  
Liqian Sun ◽  
Manman Zhao ◽  
Jingbo Zhang ◽  
Aihua Liu ◽  
Wenjun Ji ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Impairments ◽  
Amyloid Accumulation ◽  
Β Amyloid

Aromatic-interaction-mediated inhibition of β-amyloid assembly structures and cytotoxicity

2017 ◽  
Vol 23 (9) ◽  
pp. 679-684 ◽  
Author(s):  
Hanyi Xie ◽  
Jiaxi Peng ◽  
Changliang Liu ◽  
Xiaocui Fang ◽  
Hongyang Duan ◽  
...  
Keyword(s):  
Β Amyloid ◽  
Amyloid Assembly ◽  
Aromatic Interaction

scholarly journals PGRN Alleviates Cerebral Amyloid-β Burden and Cognitive Impairments via Mediating Neuroinflammation

2020 ◽  
Author(s):  
Wei Xu ◽  
Chen-Chen Tan ◽  
Xi-Peng Cao ◽  
Jin-Tai Yu ◽  
Lan Tan
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairments ◽  
Clinical Stage ◽  
Amyloid Β ◽  
Mediation Effects ◽  
Mediation Analyses ◽  
Amyloid Aβ ◽  
Β Amyloid ◽  
Tgf Β1

Abstract Background: Both progranulin (PGRN) and neuroinflammatory activities increased over the course of Alzheimer’s disease (AD). In this study, we set out to determine if cerebrospinal fluid (CSF) PGRN could be a marker of neuroinflammation, and if so, how it contributed to AD pathogenesis and cognitive impairments. Methods: A total of 965 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) were grouped within the framework of A-T-N biomarker profile and clinical stage. Causal mediation analyses with 10,000 bootstrapped iterations were conducted to explore the mediation effects of neuroinflammatory markers on the associations of PGRN with amyloid burden indicated by CSF β-amyloid (Aβ) levels. The longitudinal influences of PGRN on cognition were tested. Results: Increases of CSF PGRN and multiple neuroinflammatory markers (sTNFR1, sTNFR2, TGF-β1, VCAM1, and ICAM1) were associated with tau-related neurodegeneration, but not with Aβ pathology. PGRN was positively linked with these neuroinflammatory markers only in the presence of tau pathologies (TN+). In TN+ profile, PGRN was associated with higher CSF Aβ42 via mediating neuroinflammatory markers and could also predict slower cognitive decline. The abovementioned associations became non-significant in TN- profile. Conclusions: PGRN could protect against Aβ pathology and cognitive impairments via modulating neuroinflammation that occurs with neuronal injuries.

CSB6B prevents β-amyloid-associated neuroinflammation and cognitive impairments via inhibiting NF-κB and NLRP3 in microglia cells

2020 ◽  
Vol 81 ◽  
pp. 106263 ◽  
Author(s):  
Sicheng Yan ◽  
Zhenquan Xuan ◽  
Mengxiang Yang ◽  
Chuang Wang ◽  
Tao Tao ◽  
...  
Keyword(s):  
Cognitive Impairments ◽  
Β Amyloid

scholarly journals Characterization of a Novel Mouse Model of Alzheimer’s Disease—Amyloid Pathology and Unique β-Amyloid Oligomer Profile

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0126317 ◽  
Author(s):  
Peng Liu ◽  
Jennifer B. Paulson ◽  
Colleen L. Forster ◽  
Samantha L. Shapiro ◽  
Karen H. Ashe ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Amyloid Pathology ◽  
Model Of Alzheimer’S Disease ◽  
Β Amyloid ◽  
Amyloid Oligomer

Effects of sex hormones on Alzheimer's disease-associated β-amyloid oligomer formation in vitro

2011 ◽  
Vol 228 (2) ◽  
pp. 298-302 ◽  
Author(s):  
Akiyoshi Morinaga ◽  
Kenjiro Ono ◽  
Junichi Takasaki ◽  
Tokuhei Ikeda ◽  
Mie Hirohata ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sex Hormones ◽  
Oligomer Formation ◽  
Β Amyloid ◽  
Amyloid Oligomer

Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death

2016 ◽  
Vol 1643 ◽  
pp. 1-9 ◽  
Author(s):  
Xiaonan Wang ◽  
Xuejun Hu ◽  
Yang Yang ◽  
Toshihiro Takata ◽  
Takashi Sakurai
Keyword(s):  
Cognitive Impairment ◽  
Neuronal Death ◽  
Nicotinamide Mononucleotide ◽  
Β Amyloid ◽  
Amyloid Oligomer
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