Aqueous Date Fruit Extract can’t Ameliorate β-amyloid Induced Memory Impairments in Male Rats

2017 ◽  
Vol 17 (2) ◽  
pp. 69-75
Author(s):  
Fatemeh Mehdipour ◽  
Nader Shahrokhi ◽  
Khadijeh Esmaeilpou ◽  
Taj Pari Kalantarip ◽  
Hakime Oloumi ◽  
...  
Keyword(s):  
Male Rats ◽  
Fruit Extract ◽  
Memory Impairments ◽  
Date Fruit ◽  
Β Amyloid

scholarly journals Dichloroacetic acid-induced testicular toxicity in male rats and the protective effect of date fruit extract

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Amira El Arem ◽  
Lamia Lahouar ◽  
Emna Behija Saafi ◽  
Amira Thouri ◽  
Fatma Ghrairi ◽  
...  
Keyword(s):  
Protective Effect ◽  
Dichloroacetic Acid ◽  
Male Rats ◽  
Testicular Toxicity ◽  
Fruit Extract ◽  
Date Fruit

Nephroprotective effect of date fruit extract against dichloroacetic acid exposure in adult rats

2014 ◽  
Vol 65 ◽  
pp. 177-184 ◽  
Author(s):  
Amira El Arem ◽  
Amira Thouri ◽  
Mouna Zekri ◽  
Emna Behija Saafi ◽  
Fatma Ghrairi ◽  
...  
Keyword(s):  
Acid Exposure ◽  
Dichloroacetic Acid ◽  
Fruit Extract ◽  
Adult Rats ◽  
Date Fruit ◽  
Nephroprotective Effect

Protective effects of bilobalide on Aβ25–35 induced learning and memory impairments in male rats

2013 ◽  
Vol 106 ◽  
pp. 77-84 ◽  
Author(s):  
Yanyan Yin ◽  
Yuguo Ren ◽  
Wangyang Wu ◽  
Yuchan Wang ◽  
Mingcheng Cao ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Male Rats ◽  
Protective Effects ◽  
Memory Impairments

Kinetic Modeling and Enhanced Production of Fructose and Ethanol From Date Fruit Extract

2014 ◽  
Vol 202 (12) ◽  
pp. 1618-1627 ◽  
Author(s):  
Meilana Dharma Putra ◽  
Ahmed Elhag Abasaeed ◽  
Hasan Khader Atiyeh ◽  
Saeed Mohammed Al-Zahrani ◽  
Mohamed Hassan Gaily ◽  
...  
Keyword(s):  
Kinetic Modeling ◽  
Fruit Extract ◽  
Enhanced Production ◽  
Date Fruit

Release of acetylcholinesterase (AChE) from β-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice

2008 ◽  
Vol 175 (1-3) ◽  
pp. 142-149 ◽  
Author(s):  
Margarita C. Dinamarca ◽  
Macarena Arrázola ◽  
Enrique Toledo ◽  
Waldo F. Cerpa ◽  
Juan Hancke ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Spatial Memory ◽  
Amyloid Plaques ◽  
Memory Impairments ◽  
Β Amyloid

scholarly journals The Effectiveness of the Antiinfamation Combination Gel of Okra Fruit (Abelmoschus esculentus) Extracts and Shallots Extract (Allium cepa L.)

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Sara Nurmala ◽  
Moerfia Moerfia ◽  
Santi Novianti
Keyword(s):  
Wound Healing ◽  
Allium Cepa ◽  
The United States ◽  
Abelmoschus Esculentus ◽  
Male Rats ◽  
Cell Multiplication ◽  
Fruit Extract ◽  
White Rats ◽  
Allium Cepa L ◽  
Anti Inflammatory

Wound is a condition that is the destruction of the unity or network components, which are specifically found the substance of tissue damaged or lost, either damage the continuity of the skin, mucous membranes and bones or other organs. Wound healing is a very complex process involving many cells. The process of wound healing is portrayed as occurs in biological surgical wound occurred. Several phases of wound healing are: the process of inflammation (inflammatory), the process of cell multiplication (proliferation) and cell maturation process (maturase). Okra is a plant that allegedly came from Southeast Asia. Okra has grown in many countries in almost all over the world. In the UK okra known as the Lady's Finger, in India it is called by the name of Bhindi while the United States called Gumbo. In Indonesia, this plant also has a local name that is Rabamea (Bima), Coffee Java (Java), Arabian Coffee (Sulawesi), Hoinu (Southeast Sulawesi), but better known by the name of okra. This study aims to determine the effective concentration and determine the length of time of wound healing using a combination gel okra fruit extract (Abelmoschus esculentus) And shallots (Allium cepa L.) as an anti-inflammatory against cuts in male white rats (Sprague -Dawley) with a length of observation for 9 days. This study uses Betadine® ointment as a positive control. The results showed the combination of fruit extract gel okra 6% and shallots 2% contained in the formula 3 most effective as an anti-inflammatory against cuts in male rats by administration for 6 days.

scholarly journals The Administration of the New Pyrimidine Derivative—4-{2-[2-(3,4-Dimethoxyphenyl)-Vinyl]-6-Ethyl-4-Oxo-5-Phenyl-4H-Pyrimidine-1-Il}Benzsulfamide Restores the Activity of Brain Cells in Experimental Chronic Traumatic Encephalopathy by Maintaining Mitochondrial Function

Medicina ◽  
2019 ◽  
Vol 55 (7) ◽  
pp. 386 ◽  
Author(s):  
Pozdnyakov ◽  
Miroshnichenko ◽  
Voronkov ◽  
Kovaleva
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Mitochondrial Function ◽  
Cognitive Functions ◽  
Test Object ◽  
Chronic Traumatic Encephalopathy ◽  
Pyrimidine Derivative ◽  
Male Rats ◽  
Reference Drug ◽  
Β Amyloid

Background and objectives: To evaluate the effect of a new pyrimidine derivative on the change of mitochondrial function in experimental chronic traumatic encephalopathy. Materials and methods: The study was performed on male mice of the BALB/c line (acute toxicity was assessed) and male rats of the Wistar line, which were modeled chronic traumatic encephalopathy by the method of free fall of the load (weight 150 g from a 50 cm height). The injury to rats was reproduced once a day for 7 days. Further, cognitive functions, changes in sensorimotor deficiency, cerebral blood flow, neuron-specific enolase(NSE), S100β, glial fibrillary acidic protein (GFAP) (in blood serum) and β-amyloid, adenosine triphosphate (ATP) (in brain tissue supernatant) were evaluated. Mitochondrial respiration was also measured. Choline alfoscerate (100 mg/kg) was used as a reference drug. Results: The study found that the use of a new pyrimidine derivative contributed to the preservation of the mitochondrial respirometric function and cognitive functions in rats. In addition, against the administration of test-object marked increase in the concentration of ATP, the velocity of cerebral blood flow was 4.2 times (p < 0.05) and 35.6% (p < 0.05), respectively, as well as reduced concentration and GFAP,NSE, S100β, β-amyloid and sensorimotor deficit at 2.7 (p < 0.05) times; 2 times (p < 0.05); 2.4 times (p < 0.05); of 30.4% (p < 0.05 and 46.5% (p < 0.05), respectively. The LD50 (per os) for the test-object was 4973.56 ± 573.72 mg/kg. Conclusion: Based on the obtained data, high therapeutic efficacy and low systemic toxicity of the application are assumed 4-{2-[2-(3,4-dimethoxyphenyl)-vinyl]-6-ethyl-4-oxo-5-phenyl-4H-pyrimidine-1-Il}benzsulfamide in chronic traumatic encephalopathy.

Effects of jujube fruit extract on acetic acid-induced colitis in adult male rats

2016 ◽  
Vol 15 (1) ◽  
pp. 19 ◽  
Author(s):  
El SayedAly Mohamed Metwally ◽  
FardousSoror Karawya
Keyword(s):  
Acetic Acid ◽  
Adult Male ◽  
Male Rats ◽  
Fruit Extract ◽  
Jujube Fruit

scholarly journals Effect of Metformin on Doxorubicin-Induced Memory Dysfunction

2020 ◽  
Vol 10 (3) ◽  
pp. 152
Author(s):  
Ibrahim Alharbi ◽  
Hindi Alharbi ◽  
Yasser Almogbel ◽  
Abdullah Alalwan ◽  
Ahmad Alhowail
Keyword(s):  
Cognitive Dysfunction ◽  
Memory Impairment ◽  
Elevated Plus Maze ◽  
Male Rats ◽  
Memory Impairments ◽  
Glucose Levels ◽  
Y Maze ◽  
Altered Glucose ◽  
Plus Maze ◽  
With Memory

Doxorubicin (DOX) is widely used to treat many types of cancer; however, it is associated with chemotherapy-related complications such as cognitive dysfunction, known as chemobrain. Chemobrain affects up to 75% of cancer survivors, and there are currently no available therapeutic options. This study aims to examine whether metformin (MET) can protect against the neurotoxicity caused by DOX treatment. Forty male rats were divided into four groups (10 rats/group): control, DOX, DOX + MET, and MET. Rats treated with DOX received five doses of 4 mg/kg DOX weekly (cumulative dose: 20 mg/kg). For the DOX-MET and MET groups, MET (3 mg/mL) was dissolved in drinking water. Behavioral and glucose tests were performed one day after treatment was completed. We found DOX (4 mg/kg/week, 5 weeks) caused learning and memory impairment in the Y-maze, novel object recognition, and elevated plus maze behavioral tests. MET did not rescue these DOX-induced memory impairments. Neither DOX nor MET nor MET + DOX altered glucose levels following the treatment. In summary, DOX treatment is associated with memory impairment in rats, but MET does not rescue this cognitive dysfunction.

Sign in / Sign up

Export Citation Format

Share Document