scholarly journals Intrauterine growth restriction coupled with hyperglycemia: effects on cardiac structure in adult rats

2012 ◽  
Vol 72 (4) ◽  
pp. 344-351 ◽  
Author(s):  
Kyungjoon Lim ◽  
Paul Lombardo ◽  
Michal Schneider-Kolsky ◽  
M. Jane Black
2012 ◽  
Vol 73 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Elina Malo ◽  
Meiju Saukko ◽  
Merja Santaniemi ◽  
Mirella Hietaniemi ◽  
Eveliina Lammentausta ◽  
...  

Nutrition ◽  
2011 ◽  
Vol 27 (3) ◽  
pp. 364-371 ◽  
Author(s):  
Qian Shen ◽  
Hong Xu ◽  
Li-Ming Wei ◽  
Jing Chen ◽  
Hai-Mei Liu

2015 ◽  
Vol 1618 ◽  
pp. 41-49 ◽  
Author(s):  
Roberta Dalle Molle ◽  
Daniela Pereira Laureano ◽  
Márcio Bonesso Alves ◽  
Tatiane Madeira Reis ◽  
Mina Desai ◽  
...  

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Adriana Pereira de Souza ◽  
Amanda Paula Pedroso ◽  
Regina Lúcia Harumi Watanabe ◽  
Ana Paula Segantine Dornellas ◽  
Valter Tadeu Boldarine ◽  
...  

2021 ◽  
Author(s):  
Ekaterina Selivanova ◽  
Anastasia Shvetsova ◽  
Lyubov Shilova ◽  
Olga Tarasova ◽  
Dina Gaynullina

Abstract Intrauterine growth restriction (IUGR) is one of the most common pathologies of pregnancy. The cardiovascular consequences of IUGR do not disappear in adulthood and can manifest themselves in pathological alterations of vasomotor control. The hypothesis was tested that IUGR weakens anticontractile influence of NO and augments procontractile influence of Rho-kinase in arteries of adult offspring. To model IUGR in the rat, dams were 50% food restricted starting from the gestational day 11 till delivery. Mesenteric and coronary arteries of male offspring were studied at the age of 3 months using wire myography, qPCR, and Western Blotting. Contractile responses of mesenteric arteries to α1-adrenoceptor agonist methoxamine as well as influences of NO and Rho-kinase did not differ between control and IUGR rats. However, coronary arteries of IUGR rats demonstrated elevated contraction to thromboxane A2 receptor agonist U46619 due to weakened anticontractile influence of NO and enhanced role of Rho-kinase in the endothelium. This was accompanied by reduced abundance of SODI protein and elevated content of RhoA protein in coronary arteries of IUGR rats. IUGR considerably changes the regulation of coronary vascular tone in adulthood and, therefore, can serve as a risk factor for the development of cardiac disorders.


Respirology ◽  
2017 ◽  
Vol 22 (7) ◽  
pp. 1329-1335 ◽  
Author(s):  
Kimberley C.W. Wang ◽  
Jude S. Morton ◽  
Sandra T. Davidge ◽  
Alexander N. Larcombe ◽  
Alan L. James ◽  
...  

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