scholarly journals Plasma lipid levels and body weight altered by intrauterine growth restriction and postnatal fructose diet in adult rats

2012 ◽  
Vol 73 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Elina Malo ◽  
Meiju Saukko ◽  
Merja Santaniemi ◽  
Mirella Hietaniemi ◽  
Eveliina Lammentausta ◽  
...  
Keyword(s):  
Body Weight ◽  
Intrauterine Growth Restriction ◽  
Plasma Lipid ◽  
Growth Restriction ◽  
Lipid Levels ◽  
Adult Rats ◽  
Intrauterine Growth

Intrauterine growth restriction and postnatal high-protein diet affect the kidneys in adult rats

Nutrition ◽  
2011 ◽  
Vol 27 (3) ◽  
pp. 364-371 ◽  
Author(s):  
Qian Shen ◽  
Hong Xu ◽  
Li-Ming Wei ◽  
Jing Chen ◽  
Hai-Mei Liu
Keyword(s):  
Intrauterine Growth Restriction ◽  
High Protein Diet ◽  
Growth Restriction ◽  
High Protein ◽  
Protein Diet ◽  
Adult Rats ◽  
Intrauterine Growth

scholarly journals Intrauterine growth restriction increases the preference for palatable foods and affects sensitivity to food rewards in male and female adult rats

2015 ◽  
Vol 1618 ◽  
pp. 41-49 ◽  
Author(s):  
Roberta Dalle Molle ◽  
Daniela Pereira Laureano ◽  
Márcio Bonesso Alves ◽  
Tatiane Madeira Reis ◽  
Mina Desai ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Female Adult ◽  
Adult Rats ◽  
Male And Female ◽  
Intrauterine Growth

scholarly journals Gender-specific effects of intrauterine growth restriction on the adipose tissue of adult rats: a proteomic approach

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Adriana Pereira de Souza ◽  
Amanda Paula Pedroso ◽  
Regina Lúcia Harumi Watanabe ◽  
Ana Paula Segantine Dornellas ◽  
Valter Tadeu Boldarine ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Adult Rats ◽  
Intrauterine Growth ◽  
Specific Effects ◽  
Proteomic Approach ◽  
Gender Specific

scholarly journals LEFT VENTRICULAR REMODELING PROCEEDS FROM YOUNG ADULTHOOD INTO MIDLIFE IN INTRAUTERINE GROWTH RESTRICTION BABOONS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S106-S106
Author(s):  
Geoffrey D Clarke ◽  
Hillary Huber ◽  
Cun Li ◽  
Anderson Kuo ◽  
Peter Nathanielsz
Keyword(s):  
Body Weight ◽  
Intrauterine Growth Restriction ◽  
Ventricular Remodeling ◽  
Heart Function ◽  
Left Ventricular ◽  
Growth Restriction ◽  
Breath Holding ◽  
Control Group ◽  
Phase Array ◽  
Intrauterine Growth

Abstract Previous cross-sectional studies have shown young adult baboons (~5-6 y.o.), subjected to intrauterine growth restriction (IUGR) by maternal calorie restriction during pregnancy and lactation, exhibit ventricular remodeling with mildly impaired heart function relative to age/sex-matched controls (CTL). METHODS: In this longitudinal study cardiac MRI was performed on male IUGR baboons (n=7). A 3 Tesla, Siemens TIM Trio MRI system was used with phase-array coils with parallel imaging acquisition and breath-holding during the scan. Studies of IUGR animals occurred at 4.7 + 0.1 yr. intervals; the first scan (scan1) at 5.8 + 1.2 y (human equivalent - HE ~24 years) and the second (scan2) at 10.4 + 1.2 yr (HE~40 y). Scans on the CTL animals (N=4) occurred at 5.3 + 1.4 years and 10 + 1.4 years. RESULTS: Change in body weight over 4.7 years was less in the IUGR group (Δwt=6.3 + 6.1 kg) than in the control group (Δwt =11.5 + 8.2 kg). Left ventricular (LV) ejection fraction (EF) was significantly greater in IUGR animals for scan2 (+10.7%, p=0.03) but not in normal controls (+1.8%, p=0.75). Stroke volume and end-diastolic LV volume were normalized to body surface area (BSA). SV/BSA (17.6 + 4.9, 31.5 + 12.3 mL/sq.m; p=0.016) and EDV/BSA (47.3 + 13.6, 64.5 + 18.8 mL/sq.m; p=0.045) were also significantly increased in IUGR animals but not controls. In IUGR subjects, Δweight was significantly and positively correlated with ΔEF (r=0.86, p=0.01). CONCLUSIONS: In IUGR, but not in CTL baboons, cardiac function adaptations continue into midlife and are related to increases in body weight with aging. We conclude that IUGR programs cardiovascular function and that programmed changes continue into midlife.

scholarly journals Intrauterine growth restriction coupled with hyperglycemia: effects on cardiac structure in adult rats

2012 ◽  
Vol 72 (4) ◽  
pp. 344-351 ◽  
Author(s):  
Kyungjoon Lim ◽  
Paul Lombardo ◽  
Michal Schneider-Kolsky ◽  
M. Jane Black
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Cardiac Structure ◽  
Adult Rats ◽  
Intrauterine Growth

scholarly journals Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model

Antioxidants ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1505
Author(s):  
Natalia Yeste ◽  
Néstor Gómez ◽  
Marta Vázquez-Gómez ◽  
Consolación García-Contreras ◽  
Martí Pumarola ◽  
...  
Keyword(s):  
Body Weight ◽  
Intrauterine Growth Restriction ◽  
Maternal Nutrition ◽  
Neuronal Morphology ◽  
Growth Restriction ◽  
Poor Growth ◽  
Neuronal Markers ◽  
Intrauterine Growth ◽  
Cornu Ammonis ◽  
Neurochemical Changes

Intrauterine growth restriction (IUGR) refers to poor growth of a fetus during pregnancy due to deficient maternal nutrition or oxygen supply. Supplementation of a mother’s diet with antioxidants, such as hydroxytyrosol (HTX), has been proposed to ameliorate the adverse phenotypes of IUGR. In the present study, sows were treated daily with or without 1.5 mg of HTX per kilogram of feed from day 35 of pregnancy (at 30% of the total gestational period), and fetuses were sampled at day 100 of gestation. Fetuses were classified as normal body weight (NBW) or low body weight (LBW) as a consequence of IUGR, constituting four groups: NBW-Control, NBW-HTX, LBW-Control, and LBW-HTX. The brain was removed, and the hippocampus, amygdala, and prefrontal cortex were rapidly dissected. Neuronal markers were studied by immunohistochemistry, and a decrease in the number of mature neurons in the hippocampal Cornu Ammonis subfield 1 (CA1) and the Dentate Gyrus (DG) regions was observed in LBW fetuses together with a higher number of immature neurons and other alterations in neuronal morphology. Furthermore, IUGR conditions altered the neurotransmitter (NT) profile, since an increase in the serotonin (5-HT) pathway was observed in LBW fetuses. Supplementation with HTX was able to reverse the morphological and neurochemical changes, leading both characteristics to values similar to those of NBW fetuses.

Comparison of two models of intrauterine growth restriction for early catch-up growth and later development of glucose intolerance and obesity in rats

2010 ◽  
Vol 298 (1) ◽  
pp. R141-R146 ◽  
Author(s):  
Yasaman Shahkhalili ◽  
Julie Moulin ◽  
Irene Zbinden ◽  
Olivier Aprikian ◽  
Katherine Macé
Keyword(s):  
Body Weight ◽  
Birth Weight ◽  
Food Intake ◽  
Glucose Intolerance ◽  
Intrauterine Growth Restriction ◽  
Food Restriction ◽  
Plasma Insulin ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Catch Up

Two models of intrauterine growth restriction, maternal food restriction (FR), and dexamethasone (DEX) exposure were compared for early postnatal catch-up growth and later development of glucose intolerance and obesity in Sprague-Dawley rats. Mated dams were randomly divided into three groups at 10 days gestational age. Group FR was food restricted (50% of nongestating rats) during the last 11 days of gestation; Group DEX received DEX injections during the last week of gestation, and Group CON, the control group, had no intervention. Birth weight, catch-up growth, body weight, and food intake were measured in male offspring for 22 wk. Body composition, blood glucose, and plasma insulin in response to a glucose load were assessed at 8, 16, and 22 wk. Pups from both FR and DEX dams had similarly lower birth weights than CON (22% and 25%, P < 0.0001), but catch-up growth, which occurred during the suckling period, was much more rapid in FR than DEX offspring (6 vs. 25 days, 95% CI). Postweaning, there were no significant differences between groups in food intake, body weight, body fat, and plasma insulin, but baseline plasma glucose at 22 wk and 2-h glucose area-under-the-curve at 8 and 22 wk were greater only in FR vs. CON offspring ( P < 0.05), thereby contrasting with the lack of significant differences between DEX and CON. These results suggest that prenatal food restriction is a more sensitive model than DEX exposure for studies aimed at investigating the link between low birth weight, early postnatal catch-up growth, and later development of glucose intolerance.

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