scholarly journals HEXIM1 down-regulates hypoxia-inducible factor-1α protein stability

2013 ◽  
Vol 456 (2) ◽  
pp. 195-204 ◽  
Author(s):  
I-Ju Yeh ◽  
Ndiya Ogba ◽  
Heather Bensigner ◽  
Scott M. Welford ◽  
Monica M. Montano
Keyword(s):  
Protein Stability ◽  
Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Post Translational Modifications ◽  
Hypoxia Inducible Factor 1Α ◽  
Direct Target ◽  
Inducible Protein ◽  
Insight Into

Our studies provide new insight into the inhibition of HIF-1α (hypoxia-inducible factor 1α). We report that HIF-1α is a direct target of HEXIM1 (hexamethylene-bis-acetamide-inducible protein-1) and that HEXIM1 modulates post-translational modifications of HIF-1α. Thus HEXIM1 is a critical regulator of HIF-1α activities in cancer cells.

scholarly journals mTOR Signal and Hypoxia-Inducible Factor-1α Regulate CD133 Expression in Cancer Cells

2009 ◽  
Vol 69 (18) ◽  
pp. 7160-7164 ◽  
Author(s):  
Kazuko Matsumoto ◽  
Tokuzo Arao ◽  
Kaoru Tanaka ◽  
Hiroyasu Kaneda ◽  
Kanae Kudo ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Cd133 Expression ◽  
Hypoxia Inducible Factor 1Α

scholarly journals Activation of Peroxisome Proliferator-activated Receptor α (PPARα) Suppresses Hypoxia-inducible Factor-1α (HIF-1α) Signaling in Cancer Cells

2012 ◽  
Vol 287 (42) ◽  
pp. 35161-35169 ◽  
Author(s):  
Jundong Zhou ◽  
Shuyu Zhang ◽  
Jing Xue ◽  
Jori Avery ◽  
Jinchang Wu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Proteasome Inhibitors ◽  
Tube Formation ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Hypoxia Inducible Factor 1Α ◽  
Anticancer Properties ◽  
Pparγ Agonist ◽  
Expression And Activity

Activation of peroxisome proliferator-activated receptor α (PPARα) has been demonstrated to inhibit tumor growth and angiogenesis, yet the mechanisms behind these actions remain to be characterized. In this study, we examined the effects of PPARα activation on the hypoxia-inducible factor-1α (HIF-1α) signaling pathway in human breast (MCF-7) and ovarian (A2780) cancer cells under hypoxia. Incubation of cancer cells under 1% oxygen for 16 h significantly induced HIF-1α expression and activity as assayed by Western blotting and reporter gene analysis. Treatment of the cells with PPARα agonists, but not a PPARγ agonist, prior to hypoxia diminished hypoxia-induced HIF-1α expression and activity, and addition of a PPARα antagonist attenuated the suppression of HIF-1α signaling. Activation of PPARα attenuated hypoxia-induced HA-tagged HIF-1α protein expression without affecting the HA-tagged HIF-1α mutant protein level, indicating that PPARα activation promotes HIF-1α degradation in these cells. This was further confirmed using proteasome inhibitors, which reversed PPARα-mediated suppression of HIF-1α expression under hypoxia. Using the co-immunoprecipitation technique, we found that activation of PPARα enhances the binding of HIF-1α to von Hippel-Lindau tumor suppressor (pVHL), a protein known to mediate HIF-1α degradation through the ubiquitin-proteasome pathway. Following PPARα-mediated suppression of HIF-1α signaling, VEGF secretion from the cancer cells was significantly reduced, and tube formation by endothelial cells was dramatically impaired. Taken together, these findings demonstrate for the first time that activation of PPARα suppresses hypoxia-induced HIF-1α signaling in cancer cells, providing novel insight into the anticancer properties of PPARα agonists.

scholarly journals Erratum to “Isocudraxanthone K Induces Growth Inhibition and Apoptosis in Oral Cancer Cells via Hypoxia Inducible Factor-1α”

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Mee-Ran Shin ◽  
Hwa-Jeong Lee ◽  
Soo-Kyung Kang ◽  
Q-Schick Auh ◽  
Young-Man Lee ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factor 1Α ◽  
Oral Cancer Cells

Abstract A202: Lipocalin2 stabilizes hypoxia inducible factor-1α through the iron delivery into normoxic cancer cells

2015 ◽  
Author(s):  
Susumu Hama ◽  
Ibuki Nakamura ◽  
Akinori Nishimoto ◽  
Takayuki Nishi ◽  
Shoko Itakura ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factor 1Α ◽  
Iron Delivery

scholarly journals Toll-Iike Receptor-3 Activation Enhances Malignant Traits in Human Breast Cancer Cells Through Hypoxia-inducible Factor-1α

2020 ◽  
Vol 40 (10) ◽  
pp. 5379-5391
Author(s):  
FRANCESCA SCATOZZA ◽  
ANTONELLA D'AMORE ◽  
ROSARIA ANNA FONTANELLA ◽  
PAOLA DE CESARIS ◽  
FRANCESCO MARAMPON ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Hypoxia Inducible Factor 1Α
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