scholarly journals Abdominal adiposity in rheumatoid arthritis: Association with cardiometabolic risk factors and disease characteristics

2010 ◽  
Vol 62 (11) ◽  
pp. 3173-3182 ◽  
Author(s):  
Jon T. Giles ◽  
Matthew Allison ◽  
Roger S. Blumenthal ◽  
Wendy Post ◽  
Allan C. Gelber ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Abdominal Adiposity ◽  
Disease Characteristics

scholarly journals SAT0037 INCREASED CARDIOMETABOLIC RISK FACTORS ARE RELATED TO THE ABNORMAL ADIPOCYTOKINE PROFILE AND AUTOIMMUNITY IN RHEUMATOID ARTHRITIS. MODULATION BY TNFALPHA AND IL6R INHIBITORS

2019 ◽  
Author(s):  
Iván Arias de la Rosa ◽  
Maria del Carmen Abalos-Aguilera ◽  
Rafaela Ortega Castro ◽  
Jerusalem Calvo Gutierrez ◽  
Carlos Perez-Sanchez ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors

scholarly journals Consumption of Foods Derived from Subsidized Crops Remains Associated with Cardiometabolic Risk: An Update on the Evidence Using the National Health and Nutrition Examination Survey 2009–2014

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3244
Author(s):  
Whitney L. Do ◽  
Kai M. Bullard ◽  
Aryeh D. Stein ◽  
Mohammed K. Ali ◽  
K. M. Venkat Narayan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiometabolic Risk ◽  
Smoking Status ◽  
Cardiometabolic Risk Factors ◽  
Calorie Intake ◽  
Abdominal Adiposity ◽  
Daily Consumption ◽  
Farm Bill ◽  
Logistic Regression Models ◽  
Food Commodities

In this study, we examined the associations between the consumption of foods derived from crops subsidized under the 2008 United States (US) Farm Bill and cardiometabolic risk factors and whether the magnitude of these associations has changed since the 2002 US Farm Bill. Four federal databases were used to estimate daily consumption of the top seven subsidized commodities (corn, soybeans, wheat, rice, sorghum, dairy, and livestock) and to calculate a subsidy score (0–1 scale) for Americans’ daily dietary intake during 2009–2014, with a higher score indicative of a higher proportion of the diet derived from subsidized commodities. The cardiometabolic risk factors included obesity, abdominal adiposity, hypertension, dyslipidemia, and dysglycemia. Linear and logistic regression models were adjusted for age, sex, race/ethnicity, the poverty–income ratio, the smoking status, educational attainment, physical activity, and daily calorie intake. During 2009–2014, adults with the highest subsidy score had higher probabilities of obesity, abdominal adiposity, and dysglycemia compared to the lowest subsidy score. After the 2002 Farm Bill (measured using data from 2001–2006), the subsidy score decreased from 56% to 50% and associations between consuming a highly-subsidized diet and dysglycemia did not change (p = 0.54), whereas associations with obesity (p = 0.004) and abdominal adiposity (p = 0.002) significantly attenuated by more than half. The proportion of calories derived from subsidized food commodities continues to be associated with adverse cardiometabolic risk factors, though the relationship with obesity and abdominal adiposity has weakened in recent years.

scholarly journals Anthropometric measures of abdominal adiposity for the identification of cardiometabolic risk factors in adolescents

2014 ◽  
Vol 103 (3) ◽  
pp. e14-e17 ◽  
Author(s):  
David R. Weber ◽  
Lorraine E. Levitt Katz ◽  
Babette S. Zemel ◽  
Paul R. Gallagher ◽  
Kathryn M. Murphy ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Abdominal Adiposity ◽  
Anthropometric Measures

Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men

2007 ◽  
Vol 31 (4) ◽  
pp. 692-699 ◽  
Author(s):  
M Côté ◽  
I Matias ◽  
I Lemieux ◽  
S Petrosino ◽  
N Alméras ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Abdominal Adiposity

Adipose Tissue Macrophages in Rheumatoid Arthritis: Prevalence, Disease‐Related Indicators, and Associations With Cardiometabolic Risk Factors

2018 ◽  
Vol 70 (2) ◽  
pp. 175-184 ◽  
Author(s):  
Jon T. Giles ◽  
Antony W. Ferrante ◽  
Rachel Broderick ◽  
Afshin Zartoshti ◽  
Janine Rose ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Adipose Tissue ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Adipose Tissue Macrophages

scholarly journals Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis

2019 ◽  
Vol 110 (5) ◽  
pp. 1079-1087 ◽  
Author(s):  
Anna Viitasalo ◽  
Theresia M Schnurr ◽  
Niina Pitkänen ◽  
Mette Hollensted ◽  
Tenna R H Nielsen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Children And Adolescents ◽  
Cardiometabolic Risk ◽  
Dietary Habits ◽  
Mendelian Randomization ◽  
Causal Effect ◽  
Genetic Risk Score ◽  
Cardiometabolic Risk Factors ◽  
Abdominal Adiposity ◽  
Increased Risk

ABSTRACT Background Mendelian randomization studies in adults suggest that abdominal adiposity is causally associated with increased risk of type 2 diabetes and coronary artery disease in adults, but its causal effect on cardiometabolic risk in children remains unclear. Objective We aimed to study the causal relation of abdominal adiposity with cardiometabolic risk factors in children by applying Mendelian randomization. Methods We constructed a genetic risk score (GRS) using variants previously associated with waist-to-hip ratio adjusted for BMI (WHRadjBMI) and examined its associations with cardiometabolic factors by linear regression and Mendelian randomization in a meta-analysis of 6 cohorts, including 9895 European children and adolescents aged 3–17 y. Results WHRadjBMI GRS was associated with higher WHRadjBMI (β = 0.021 SD/allele; 95% CI: 0.016, 0.026 SD/allele; P = 3 × 10−15) and with unfavorable concentrations of blood lipids (higher LDL cholesterol: β = 0.006 SD/allele; 95% CI: 0.001, 0.011 SD/allele; P = 0.025; lower HDL cholesterol: β = −0.007 SD/allele; 95% CI: −0.012, −0.002 SD/allele; P = 0.009; higher triglycerides: β = 0.007 SD/allele; 95% CI: 0.002, 0.012 SD/allele; P = 0.006). No differences were detected between prepubertal and pubertal/postpubertal children. The WHRadjBMI GRS had a stronger association with fasting insulin in children and adolescents with overweight/obesity (β = 0.016 SD/allele; 95% CI: 0.001, 0.032 SD/allele; P = 0.037) than in those with normal weight (β = −0.002 SD/allele; 95% CI: −0.010, 0.006 SD/allele; P = 0.605) (P for difference = 0.034). In a 2-stage least-squares regression analysis, each genetically instrumented 1-SD increase in WHRadjBMI increased circulating triglycerides by 0.17 mmol/L (0.35 SD, P = 0.040), suggesting that the relation between abdominal adiposity and circulating triglycerides may be causal. Conclusions Abdominal adiposity may have a causal, unfavorable effect on plasma triglycerides and potentially other cardiometabolic risk factors starting in childhood. The results highlight the importance of early weight management through healthy dietary habits and physically active lifestyle among children with a tendency for abdominal adiposity.

scholarly journals Complement component 3 as biomarker of disease activity and cardiometabolic risk factor in rheumatoid arthritis and spondyloarthritis

2020 ◽  
Vol 11 ◽  
pp. 204062232096506
Author(s):  
Iván Arias de la Rosa ◽  
Pilar Font ◽  
Alejandro Escudero-Contreras ◽  
María Dolores López-Montilla ◽  
Carlos Pérez-Sánchez ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Disease Activity ◽  
Cardiometabolic Risk ◽  
Curve Analysis ◽  
Cardiometabolic Risk Factors ◽  
Complement C3 ◽  
Roc Curve Analysis ◽  
Complement Component 3

Objective: To analyze the relationship between complement component 3 (C3) and the prevalence of cardiometabolic risk factors and disease activity in the rheumatic diseases having the highest rates of cardiovascular morbidity and mortality: rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA). Methods: This is a cross-sectional study including 200 RA, 80 PsA, 150 axSpA patients and 100 healthy donors. The prevalence of cardiometabolic risk factors [obesity, insulin resistance, type 2 diabetes mellitus, hyperlipidemia, apolipoprotein B/apolipoprotein A (apoB/apoA) and atherogenic risks and hypertension] was analyzed. Serum complement C3 levels, inflammatory markers and disease activity were evaluated. Cluster analysis was performed to identify different phenotypes. Receiver operating characteristic (ROC) curve analysis to assess the accuracy of complement C3 as biomarker of insulin resistance and disease activity was carried out. Results: Levels of complement C3, significantly elevated in RA, axSpA and PsA patients, were associated with the prevalence of cardiometabolic risk factors. Hard clustering analysis identified two distinctive phenotypes of patients depending on the complement C3 levels and insulin sensitivity state. Patients from cluster 1, characterized by high levels of complement C3 displayed increased prevalence of cardiometabolic risk factors and high disease activity. ROC curve analysis showed that non-obesity related complement C3 levels allowed to identify insulin resistant patients. Conclusions: Complement C3 is associated with the concomitant increased prevalence of cardiometabolic risk factors in rheumatoid arthritis and spondyloarthritis. Thus, complement C3 should be considered a useful marker of insulin resistance and disease activity in these rheumatic disorders.

scholarly journals The Association Between Cardiorespiratory Fitness and Cardiometabolic Risk in Children is Mediated by Abdominal Adiposity: The HAPPY Study

2015 ◽  
Vol 12 (8) ◽  
pp. 1148-1152 ◽  
Author(s):  
Daniel P. Bailey ◽  
Louise A. Savory ◽  
Sarah J. Denton ◽  
Catherine J. Kerr
Keyword(s):  
Risk Factors ◽  
Cardiorespiratory Fitness ◽  
Cardiometabolic Risk ◽  
Cycle Ergometer ◽  
Cardiometabolic Risk Factors ◽  
Cardiometabolic Health ◽  
Abdominal Adiposity ◽  
Cross Sectional ◽  
Cycle Ergometer Test ◽  
Health Related

Background:It is unclear whether cardiorespiratory fitness (CRF) is independently linked to cardiometabolic risk in children. This study investigated a) the association between CRF level and presence of cardiometabolic risk disorders using health-related cut points, and b) whether these associations were mediated by abdominal adiposity in children.Methods:This was a cross-sectional design study. Anthropometry, biochemical parameters and CRF were assessed in 147 schoolchildren (75 girls) aged 10 to 14 years. CRF was determined using a maximal cycle ergometer test. Children were classified as ‘fit’ or ‘unfit’ according to published thresholds. Logistic regression was used to investigate the odds of having individual and clustered cardiometabolic risk factors according to CRF level and whether abdominal adiposity mediated these associations.Results:Children classified as unfit had increased odds of presenting individual and clustered cardiometabolic risk factors (P < .05), but these associations no longer remained after adjusting for abdominal adiposity (P > .05).Conclusions:This study suggests that the association between CRF and cardiometabolic risk is mediated by abdominal adiposity in 10- to 14-year-old children and that abdominal adiposity may be a more important determinant of adverse cardiometabolic health in this age group.

scholarly journals Association of vitamin D with cardiometabolic risk factors in rheumatoid arthritis

2012 ◽  
Vol 64 (10) ◽  
pp. 1497-1504 ◽  
Author(s):  
Uzma J. Haque ◽  
Joan M. Bathon ◽  
Jon T. Giles
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Vitamin D ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors
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