Retrotransposons jump into alternative-splicing regulation via a long noncoding RNA

2016 ◽  
Vol 23 (11) ◽  
pp. 952-954 ◽  
Author(s):  
Reini F Luco
Keyword(s):  
Alternative Splicing ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Splicing Regulation

scholarly journals Long Noncoding RNA Modulates Alternative Splicing Regulators in Arabidopsis

2014 ◽  
Vol 30 (2) ◽  
pp. 166-176 ◽  
Author(s):  
Florian Bardou ◽  
Federico Ariel ◽  
Craig G. Simpson ◽  
Natali Romero-Barrios ◽  
Philippe Laporte ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Splicing Regulators

scholarly journals Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro

2020 ◽  
Vol 21 (16) ◽  
pp. 5605
Author(s):  
Anna Fefilova ◽  
Pavel Melnikov ◽  
Tatiana Prikazchikova ◽  
Tatiana Abakumova ◽  
Ilya Kurochkin ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Regulation Mechanism ◽  
Protein Targets ◽  
Nonsense Mediated Decay ◽  
Cellular Processes ◽  
Pou Domain ◽  
Premature Termination Codons

The coupling of alternative splicing with the nonsense-mediated decay (NMD) pathway maintains quality control of the transcriptome in eukaryotes by eliminating transcripts with premature termination codons (PTC) and fine-tunes gene expression. Long noncoding RNA (lncRNA) can regulate multiple cellular processes, including alternative splicing. Previously, murine Morrbid (myeloid RNA repressor of Bcl2l11 induced death) lncRNA was described as a locus-specific controller of the lifespan of short-living myeloid cells via transcription regulation of the apoptosis-related Bcl2l11 protein. Here, we report that murine Morrbid lncRNA in hepatocytes participates in the regulation of proto-oncogene NRAS (neuroblastoma RAS viral oncogene homolog) splicing, including the formation of the isoform with PTC. We observed a significant increase of the NRAS isoform with PTC in hepatocytes with depleted Morrbid lncRNA. We demonstrated that the NRAS isoform with PTC is degraded via the NMD pathway. This transcript is presented almost only in the nucleus and has a half-life ~four times lower than other NRAS transcripts. Additionally, in UPF1 knockdown hepatocytes (the key NMD factor), we observed a significant increase of the NRAS isoform with PTC. By a modified capture hybridization (CHART) analysis of the protein targets, we uncovered interactions of Morrbid lncRNA with the SFPQ (splicing factor proline and glutamine rich)-NONO (non-POU domain-containing octamer-binding protein) splicing complex. Finally, we propose the regulation mechanism of NRAS splicing in murine hepatocytes by alternative splicing coupled with the NMD pathway with the input of Morrbid lncRNA.

scholarly journals Imprinted Chromatin around DIRAS3 Regulates Alternative Splicing of GNG12-AS1, a Long Noncoding RNA

2013 ◽  
Vol 93 (2) ◽  
pp. 224-235 ◽  
Author(s):  
Malwina Niemczyk ◽  
Yoko Ito ◽  
Joanna Huddleston ◽  
Anna Git ◽  
Sayeda Abu-Amero ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Long Noncoding Rna ◽  
Noncoding Rna

Alternative Splicing of a Transposable Element into the Human Long Noncoding RNA CARMEN Is a Switch for Cardiac Precursor Cell Specification

2021 ◽  
Author(s):  
Isabelle Plaisance ◽  
Panagiotis Chouvardas ◽  
Yuliangzi Sun ◽  
Mohamed Nemir ◽  
Parisa Aghagolzadeh ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Transposable Element ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Precursor Cell ◽  
Cell Specification ◽  
Rna I
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