The Long Noncoding RNA Ctcflos Orchestrates Transcriptional and Post-Transcriptional Alternative Splicing Programs Essential for Thermogenic Gene Expression in Brite Adipocytes

2020 ◽  
Author(s):  
Andrea Bast-Habersbrunner ◽  
Christoph Kiefer ◽  
Peter Weber ◽  
Tobias Fromme ◽  
Anna Schießl ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alternative Splicing ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Rna I

Alternative Splicing of a Transposable Element into the Human Long Noncoding RNA CARMEN Is a Switch for Cardiac Precursor Cell Specification

2021 ◽  
Author(s):  
Isabelle Plaisance ◽  
Panagiotis Chouvardas ◽  
Yuliangzi Sun ◽  
Mohamed Nemir ◽  
Parisa Aghagolzadeh ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Transposable Element ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Precursor Cell ◽  
Cell Specification ◽  
Rna I

Long noncoding RNA HOTTIP cooperates with CCCTC-binding factor to coordinate HOXA gene expression

2018 ◽  
Vol 500 (4) ◽  
pp. 852-859 ◽  
Author(s):  
Feng Wang ◽  
Zhongqiong Tang ◽  
Honglian Shao ◽  
Jun Guo ◽  
Tao Tan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Binding Factor ◽  
Hoxa Gene Expression ◽  
Hoxa Gene

scholarly journals Overexpression of Long Noncoding RNA HOTAIR Is a Unique Epigenetic Characteristic of Myxopapillary Ependymoma

2020 ◽  
Vol 79 (11) ◽  
pp. 1193-1202
Author(s):  
Haiyin Zheng ◽  
Katherina Baranova ◽  
Jun Song ◽  
Lei Yan ◽  
Saumik Biswas ◽  
...  
Keyword(s):  
Gene Expression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Hox Genes ◽  
Spinal Tumors ◽  
Myxopapillary Ependymoma ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Rna In Situ Hybridization ◽  
Lncrna Hotair

Abstract Ependymomas are a heterogeneous group of central nervous system tumors. Despite the recent advances, there are no specific biomarkers for ependymomas. In this study, we explored the role of homeobox (HOX) genes and long noncoding RNA (LncRNA) HOTAIR in ependymomas along the neural axis. Bioinformatics analysis was performed on publicly available gene expression data. Quantitative RT-PCR was used to determine the mRNA expression level among different groups of ependymomas. RNA in situ hybridization (ISH) with probes specific to HOTAIR was performed on tumor tissue microarray (TMA) constructed with 19 ependymomas formalin-fixed paraffin-embedded tissue. Gene expression analysis revealed higher expression of posterior HOX genes and HOTAIR in myxopapillary ependymoma (MPE), in comparison to other spinal and intracranial ependymoma. qRT-PCR confirmed the high HOXD10 expression in spinal MPEs. There was a significant upregulation of HOTAIR expression in spinal MPE and elevated HOTAIR expressions were further confirmed by RNA ISH on the TMA. Intriguingly, HOXD10 and HOTAIR expressions were not elevated in nonependymoma spinal tumors. Our collective results suggest an important role for the lncRNA HOTAIR and posterior HOX genes in the tumorigenesis of spinal MPE. HOTAIR may also serve as a potential diagnostic marker for spinal MPE.

scholarly journals Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Guangbing Li ◽  
Haohai Zhang ◽  
Xueshuai Wan ◽  
Xiaobo Yang ◽  
Chengpei Zhu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Regulation Of Gene Expression ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Comprehensive Review ◽  
Cellular Processes

Long noncoding RNAs (lncRNAs) have been attracting immense research interests. However, only a handful of lncRNAs had been thoroughly characterized. They were involved in fundamental cellular processes including regulation of gene expression at epigenetics as well as tumorogenesis. In this paper, we give a systematic and comprehensive review of existing literature about lncRNA involvement in hepatocellular carcinoma. This review exhibited that lncRNAs played important roles in tumorigenesis and subsequent prognosis and metastasis of hepatocellular carcinoma and elucidated the role of some specific lncRNAs such as MALAT1 and HOTAIR in the pathophysiology of hepatocellular carcinoma and their potential of being therapeutic targets.

scholarly journals Sequential expression of long noncoding RNA as mRNA gene expression in specific stages of mouse spermatogenesis

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Meng Liang ◽  
Wenqing Li ◽  
Hui Tian ◽  
Tao Hu ◽  
Lu Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Mrna Gene ◽  
Mrna Gene Expression
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