scholarly journals The voltage-dependent gate in MthK potassium channels is located at the selectivity filter

2012 ◽  
Vol 20 (2) ◽  
pp. 159-166 ◽  
Author(s):  
David J Posson ◽  
Jason G McCoy ◽  
Crina M Nimigean
Keyword(s):  
Potassium Channels ◽  
Selectivity Filter ◽  
Voltage Dependent

scholarly journals Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels.

1991 ◽  
Vol 266 (12) ◽  
pp. 7583-7587
Author(s):  
M P Kavanaugh ◽  
M D Varnum ◽  
P B Osborne ◽  
M J Christie ◽  
A E Busch ◽  
...  
Keyword(s):  
Amino Acid ◽  
Potassium Channels ◽  
Amino Acid Residues ◽  
Voltage Dependent

scholarly journals Activation-inactivation of potassium channels and development of the potassium-channel spike in internally perfused squid giant axons.

1981 ◽  
Vol 78 (1) ◽  
pp. 43-61 ◽  
Author(s):  
I Inoue
Keyword(s):  
Potassium Channels ◽  
Potassium Channel ◽  
Voltage Clamp ◽  
Time Constant ◽  
Equilibrium Potential ◽  
Giant Axons ◽  
Dependent Inactivation ◽  
Voltage Dependent ◽  
Time Courses ◽  
Calcium Permeability

A spike that is the result of calcium permeability through potassium channels was separated from the action potential is squid giant axons internally perfused with a 30 mM NaF solution and bathed in a 100 mM CaCl2 solution by blocking sodium channels with tetrodotoxin. Currents through potassium channels were studied under voltage clamp. The records showed a clear voltage-dependent inactivation of the currents. The inactivation was composed of at least two components; one relatively fast, having a time constant of 20--30 ms, and the other very slow, having a time constant of 5--10 s. Voltage clamp was carried out with a variety of salt compositions in both the internal and external solutions. A similar voltage-dependent inactivation, also composed of the two components, was recognized in all the current through potassium channels. Although the direction and intensity of current strongly depended on the salt composition of the solutions, the time-courses of these currents at corresponding voltages were very similar. These results strongly suggest that the inactivation of the currents in attributable to an essential, dynamic property of potassium channels themselves. Thus, the generation of a potassium-channel spike can be understood as an event that occurs when the equilibrium potential across the potassium channel becomes positive.

scholarly journals Probing the Cavity of the Slow Inactivated Conformation of Shaker Potassium Channels

2007 ◽  
Vol 129 (5) ◽  
pp. 403-418 ◽  
Author(s):  
Gyorgy Panyi ◽  
Carol Deutsch
Keyword(s):  
Potassium Channels ◽  
Binding Site ◽  
Conformational Change ◽  
Marked Decrease ◽  
Selectivity Filter ◽  
Slow Inactivation ◽  
Voltage Gated ◽  
Activation Gate ◽  
Shaker Potassium Channels

Slow inactivation involves a local rearrangement of the outer mouth of voltage-gated potassium channels, but nothing is known regarding rearrangements in the cavity between the activation gate and the selectivity filter. We now report that the cavity undergoes a conformational change in the slow-inactivated state. This change is manifest as altered accessibility of residues facing the aqueous cavity and as a marked decrease in the affinity of tetraethylammonium for its internal binding site. These findings have implications for global alterations of the channel during slow inactivation and putative coupling between activation and slow-inactivation gates.

scholarly journals Role of L‐type voltage dependent calcium and large conductance potassium channels in adenosine A 1 receptor mediated vasoconstriction through Cyp4a

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Swati S Kunduri ◽  
Mohammed A Nayeem ◽  
Dovenia S Ponnoth ◽  
Stephen Tilley ◽  
S. Jamal Mustafa
Keyword(s):  
Potassium Channels ◽  
Voltage Dependent

Blockade of two voltage-dependent potassium channels, mKv1.1 and mKv1.2, by docosahexaenoic acid

1996 ◽  
Vol 314 (3) ◽  
pp. 393-396 ◽  
Author(s):  
Jennifer C. Garratt ◽  
Matthew P. McEvoy ◽  
David G. Owen
Keyword(s):  
Potassium Channels ◽  
Docosahexaenoic Acid ◽  
Voltage Dependent

scholarly journals Molecular Determinants of Voltage-Dependent Gating in hERG Potassium Channels

2012 ◽  
Vol 102 (3) ◽  
pp. 329a
Author(s):  
Yen May Cheng ◽  
Christina M. Hull ◽  
Christine M. Niven ◽  
Charlene R. Allard ◽  
Tom W. Claydon
Keyword(s):  
Potassium Channels ◽  
Molecular Determinants ◽  
Voltage Dependent
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